Marcelo Tavares, MD, PhD

#Dapagliflozin in CKD Patients with #Fabry Disease

#VisualAbstract by Elba Medina

https://www.kireports.org/article/S2468-0249(25)00760-0/fulltext

¡Hola #NephSky @rosertorra.bsky.social @ndt-era.bsky.social
@mdabdulqader83.bsky.social @alanepes.bsky.social

Síndrome de #Alport y trasplante renal :

The schematic diagram compares traditional versus precision medicine approaches to the treatment of FSGS. By categorizing FSGS into subtypes based on non-invasive molecular and genetic profiling, precision medicine enables initiation of disease modifying therapy that targets the injury pathway activated in an individual patient together with non-specific renoprotective drugs. This combined treatment regimen will increase the likelihood of a treatment response and achieve improved kidney health outcomes compared to sequential prescription of renoprotective agents followed by empirical immunosuppressive therapy (IST). Created with BioRender.com

Current and Future Therapeutics for Focal Segmental Glomerular Sclerosis in the Era of Precision Medicine: A Review

bit.ly/4rb5B6P (OPEN ACCESS)

Evaluation of ravulizumab trough levels in pediatric complement-mediated hemolytic uremic syndrome in remission

Ravulizumab drug monitoring has not been explored for mor maintenance therapy in patients w/complement-mediated (atypical) hemolytic uremic syndrome (aHUS). Read this Original Article on ravulizumab trough levels in aHUS in remission.
link.springer.com/article/10.1...

🧬 C3G
APPEAR-C3G or VALIANT?

📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%

🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org

🦋 join us today on #nephjc

Local environment, socioeconomic status, and health literacy: key modifiers of adherence in pediatric nephrology

Pediatric nephrology patients have high rates of treatment nonadherence, increasing their risk for poor health outcomes. Read this Educational Review of local environment, socioeconomic status, & health literacy: key modifiers of adherence in pediatric nephrology.
link.springer.com/article/10.1...

Povetacicept Shows Disease-Modifying Potential in IgAN and Primary MN | Docwire News Povetacicept showed sustained proteinuria reduction and stable glomerular filtration rate at 48 weeks for patients with IgA nephropathy and primary membranous nephropathy.

ICYMI: RUBY-3 demonstrates that targeting BAFF and APRIL with povetacicept can drive proteinuria reduction and immunologic remission in IgAN and pMN. #KidneyWk #nephsky #Nephrology #ClinicalTrials www.docwirenews.com/post/povetac...

#Antimeningococcal #Protection in Patients Receiving Terminal #ComplementInhibitors

#VisualAbstract by Renz Michael Pasilan

https://www.kireports.org/article/S2468-0249(25)00710-7/fulltext

Interesting discussion as well as results on the proposal of a pediatric KDIGO (p-KDIGO) criteria for AKI in children. Worth the read!

Saïdi M, Brochériou I, Estève E, et al. The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets with Different Outcomes. Kidney Int Rep. 2021;6(7):1977-1980.

Ravindran A, Casal Moura M, Fervenza FC, Nasr SH, et al. In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes. J Am Soc Nephrol. 2021 Mar;32(3):695-706.

(1/5) Day 2: Although the findings of membranous (RPS class V) lupus nephritis (LN) are not technically scored by the modified NIH activity index system, it is a variant of LN which occurs with significant proteinuria and potential loss of renal function...

#lupus #pathsky #nephsky

IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency

bit.ly/3Le1OFK

New out today:

Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial

Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...

Fenofibrate-Induced Osmotic Nephropathy: A Novel Mechanism of Acute Kidney Injury

Case Report by Raymond Lin, Seethalakshmi Viswanathan, and Nikki L. Wong

bit.ly/4mJDWrz

The image has a red background. On the top left corner in a black box is the text, "ESC." In the upper right corner is the "JN" logo. In the center is the white text, "Read papers from the JAMA Network."

📌 You can read all the JAMA and @jamacardiology.com papers presented today at #ESCCongress 2025.

ja.ma/4lNEdZf

ISN around the world: Celebrating excellence and education - International Society of Nephrology

At the 60th ANZSN Congress in Perth, ISN President-Elect @kidneydoc101.bsky.social‬ joins as speaker & moderator, highlighting ISN’s commitment to global perspectives & collaboration to advance kidney health 🌍🩺

www.theisn.org/blog/2025/09... #ANZSN60

Bluesky Social media as it should be. Find your community among millions of users, unleash your creativity, and have some fun again.

@winnicott-trust.bsky.social There are certainly many admirers of Winnicott's works in bsky.social ! Time to @winnicott-trust.bsky.social help spread his ideas!

Now open access in @ndt-era.bsky.social

Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications

🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies

▶️ academic.oup.com/ndt/article/...

#RenalPath: Antibody-mediated acute rejection with glomerulitis: increased intracapillary leukocytes (arrows) in glomerular tuft (Jones silver stain).

bit.ly/2uShEyu (FREE)

JAMA Special Communication: Reducing Barriers to Mental Health Care for Physicians. Overview & Strategic Recommendations. Published online August 14, 2025. Discusses challenges and initiatives.

Eliminating barriers to #mentalhealth care for physicians is essential to prevent untreated conditions and suicides, improve well-being, and maintain high-quality patient care.

ja.ma/4moVdGo

CALL FOR SUBMISSIONS:

Have you encountered a tricky case that could be submitted as a Quiz to help others learn?

Details on the #AJKDBlog: bit.ly/4bQAHdq

All Quizzes are freely available: bit.ly/40nVK19

Re”FINE”ing the role of non steroidal MRAs in Cardio Kidney Metabolic syndrome — NephJC This week, we will discuss non-steroidal mineralocorticoid antagonist in the multiverse of cardiovascular-kidney-metabolic. What FINEHEART pooled analysis would add to what we already learned from FID...

Finerenone gets the HFpEF nod from FDA - as expected

NephJC coverage of FINEHEARTS www.nephjc.com/news/fineheart

Our editorial on kidney outcomes from FINEARTS: pubmed.ncbi.nlm.nih.gov/39814475/

Gut microbiota are key regulators of systemic health, influencing kidney development, function, & blood pressure regulation. Read this Review of the role of microbiota-derived short-chain fatty acids in kidney physiology & development. Open Access.
link.springer.com/article/10.1...

Hispanics, the fastest growing minority in the USA, suffer from high CKD burden. Read this Original Article on healthcare access barriers for Hispanic pediatric nephrology patients. Part of a KICK (Kidney Initiative in Community Kids) study. Open Access.
link.springer.com/article/10.1...

Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline AbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a

New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...

Episode 9: Carla Nester on C3 Glomerulopathy and Complement-Mediated Diseases | GN in Ten | Episode 9 In this episode, world-renowned complement expert Carla Nester (University of Iowa) joins Koyal and Kenar to discuss the state of the art in C3 glomerulopathy and other complement-mediated kidney dise...

🎙️World-renowned complement expert Carla Nester joins Koyal Jain and @kdjhaveri.bsky.social on GN in Ten to talk C3G and all things complement-mediated kidney disease share.transistor.fm/s/67f1e0de

🔜 More C3G insights on the way after this week's SEISMIC summit is-gd.org/seismic-summit

#RenalPath: CNI nephrotoxicity with TMA involving an arteriole (Jones silver stain).

bit.ly/2qeBWhV (FREE)

Using an MRA empiricially or renin-guided therapy in apparent treatment resistant hypertension?

academic.oup.com/ajh/article/...

#WeekendReads from the #EditorsChoice archives

Herpes Zoster Vaccination and Dementia Occurrence

Herpes zoster vaccination eligibility reduced the probability of new dementia diagnoses, suggesting its potential preventive effect.

https://ja.ma/4lagSB6