Clemens Schulte

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

Our eSylites are on the cover of the current #JACS issue! Check it out 👇

Make sure not to miss our latest paper out now in #JACS - presenting eSylites - small, peptide-based probes for precise mapping of neurons, etc.!

Microscale thermophoresis (MST) played a huge part in optimizing the probes structure and sequence for binding affinity.

#ChemicalBiology #Synapse

🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio

Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky

Super excited to finally see the final version of this paper online 😁
Great team effort combining biophysics and #CryoEM for development of HepB aggregating compounds!
Huge thx to everyone involved!

PROTAC protein degraders to drug the undruggable enter phase 3 trials Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological disorders.

www.nature.com/articles/d41...