Amber Ridgway πŸͺ°'s Avatar

Amber Ridgway πŸͺ°

@amberridgway.bsky.social

Postdoctoral researcher in Mia Levine’s Lab, University of Pennsylvania Love all things Drosophila, evolution, running and Eastenders

292 Followers  |  169 Following  |  12 Posts  |  Joined: 12.01.2024  |  2.0447

Latest posts by amberridgway.bsky.social on Bluesky

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Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

28.11.2025 17:22 β€” πŸ‘ 118    πŸ” 64    πŸ’¬ 6    πŸ“Œ 4
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Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work

27.11.2025 20:43 β€” πŸ‘ 27    πŸ” 14    πŸ’¬ 0    πŸ“Œ 0
An advertisement for the project Cryptc consequences of a selfish X chromosome. It shows chromosome mapping indicating many inversions, flies with eye colour phenotypes (wild-type brighter than selfish X), and sections of testes that show ordered (wild-type) or deformed structure (selfish X).

An advertisement for the project Cryptc consequences of a selfish X chromosome. It shows chromosome mapping indicating many inversions, flies with eye colour phenotypes (wild-type brighter than selfish X), and sections of testes that show ordered (wild-type) or deformed structure (selfish X).

We have a funded NERC PhD studentship!

Selfish X chromosomes are these bizarre things where males carrying the selfish X suffer from imploding testes. Lots to do in this space, especially in evolutionary, stress, and infection biology.

Please share!

#PhDchat #AcademicSky @uniexecec.bsky.social

15.11.2025 15:01 β€” πŸ‘ 11    πŸ” 14    πŸ’¬ 2    πŸ“Œ 0

One week left to apply for this position!

11.11.2025 14:31 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
Ichetucknee Springs State Park, a short drive from Gainesville, FL

Ichetucknee Springs State Park, a short drive from Gainesville, FL

The Hopkins Lab (hopkins-lab.com) at the University of Florida is looking to recruit a postdoc to work on the genetics of organ function and evolution across Drosophila and beyond. Please visit tinyurl.com/vcsjpmzz or email me for more info. And please RT or send to anyone who might be interested!

15.10.2025 20:42 β€” πŸ‘ 37    πŸ” 41    πŸ’¬ 3    πŸ“Œ 2
Graphical abstract: The Drosophila OSC Genome as a resource for transposon and piRNA biology. The figure illustrates the workflow and key findings. Left: De novo genome assembly using Oxford Nanopore Technologies (ONT) long reads and Hi-C data generates a phased assembly distinguishing unique (blue) and repetitive (orange) sequences. Dot plot comparison between OSC-r1.01 and dm6 reference genomes shows overall synteny with extensive structural variation. Middle: A freely accessible UCSC genome browser session displays multi-omics data tracks including gene models, transposon insertions, chromatin accessibility, transcription, small RNAs, and histone modifications. Right: New insights into flamenco piRNA cluster biology reveal >730 kb transcribed from a single promoter without major splicing. Tethering assays demonstrate long-range silencing effects across the locus, and genome browser tracks show coordinated regulation of piRNA production, transcription, and chromatin state. This resource enables comprehensive studies of transposon regulation and piRNA pathway function in a widely-used Drosophila cell line.

Graphical abstract: The Drosophila OSC Genome as a resource for transposon and piRNA biology. The figure illustrates the workflow and key findings. Left: De novo genome assembly using Oxford Nanopore Technologies (ONT) long reads and Hi-C data generates a phased assembly distinguishing unique (blue) and repetitive (orange) sequences. Dot plot comparison between OSC-r1.01 and dm6 reference genomes shows overall synteny with extensive structural variation. Middle: A freely accessible UCSC genome browser session displays multi-omics data tracks including gene models, transposon insertions, chromatin accessibility, transcription, small RNAs, and histone modifications. Right: New insights into flamenco piRNA cluster biology reveal >730 kb transcribed from a single promoter without major splicing. Tethering assays demonstrate long-range silencing effects across the locus, and genome browser tracks show coordinated regulation of piRNA production, transcription, and chromatin state. This resource enables comprehensive studies of transposon regulation and piRNA pathway function in a widely-used Drosophila cell line.

When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧡 (1/12)

14.10.2025 20:34 β€” πŸ‘ 66    πŸ” 24    πŸ’¬ 3    πŸ“Œ 4
Front cover of the European Butterfly Red List, showing Polyommatus humedasae. The report can be downloaded at https://www.bc-europe.eu/webpage.php?name=red-list-butterflies-2025

Front cover of the European Butterfly Red List, showing Polyommatus humedasae. The report can be downloaded at https://www.bc-europe.eu/webpage.php?name=red-list-butterflies-2025

The new European Butterfly Red List is published today, with worrying findings. Over 1/4 (28%) of Europe’s 442 species are threatened with extinction or are close to being so. The situation is far worse for our 148 endemic species, 40% are now threatened or nearly so www.bc-europe.eu/webpage.php?...

11.10.2025 09:17 β€” πŸ‘ 163    πŸ” 107    πŸ’¬ 3    πŸ“Œ 5
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DPhil in Interdisciplinary Life and Environmental Science | About the courseThe DPhil in Interdisciplinary Life and Environmental Science provides innovative training for graduates from a wide range of academic backgrounds who wish to conduct leading-edge

Great opportunity to do a PhD with me through the ILESA PhD programme in Oxford with #Drosophila #Microscopy #Genetics. Check out what the programme is about below and DM me for more information!
www.ox.ac.uk/admissions/g...

26.09.2025 11:48 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

02.09.2025 17:26 β€” πŸ‘ 58    πŸ” 24    πŸ’¬ 0    πŸ“Œ 0

attention πŸͺ°folks. many of you received a survey from @genetics-gsa.bsky.social about potential future sites of the US Fly meeting. We are excited for #Dros26 Chicago, but future sites are in question, for many logistical reasons. GSA is hard at work planning, but we need to hear from you. please RT!

06.08.2025 17:32 β€” πŸ‘ 11    πŸ” 14    πŸ’¬ 2    πŸ“Œ 0

Huge congrats Ben, that’s incredible news!!

19.06.2025 00:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

03.06.2025 21:17 β€” πŸ‘ 83    πŸ” 115    πŸ’¬ 0    πŸ“Œ 12
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Simons Graduate Fellowships in Ecology and Evolution The purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...

Get the word out far and wide. New opportunity from the Simons Foundation in the Eco-Evo space.

2026 Simons Graduate Fellowship in Ecology and Evolution Awards, due July 31, 2025, only for incoming PhD students who plan to start their PhDs in Fall 2026.

www.simonsfoundation.org/grant/simons...

02.06.2025 16:08 β€” πŸ‘ 51    πŸ” 77    πŸ’¬ 2    πŸ“Œ 3

Buzzing to see this published! Before selecting my PhD, I spent three months in the Flashman lab working on this project. Since then, this novel tool has been extensively and beautifully characterized - well done to all the authors!

09.05.2025 18:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

06.04.2025 16:24 β€” πŸ‘ 38    πŸ” 41    πŸ’¬ 1    πŸ“Œ 1
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Gene Regulatory Networks Driving Male-Female Genital Co-evolution at Oxford Brookes University on FindAPhD.com PhD Project - Gene Regulatory Networks Driving Male-Female Genital Co-evolution at Oxford Brookes University, listed on FindAPhD.com

Join us to investigate the evolutionary-developmental basis of genital co-evolution between sexes! Strong candidates will have an interest in #EvoDevo & #SexualSelection
and Skills in #Drosophilagenetics, Transgenesis or Bioinformatics

DM for details.
tinyurl.com/yesyjyfd

02.04.2025 11:18 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘡𝘸𝘦𝘦𝘯 cells? 🀯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread πŸ§΅πŸ‘‡

17.03.2025 11:56 β€” πŸ‘ 545    πŸ” 259    πŸ’¬ 11    πŸ“Œ 33
Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species

Happy to share our Slow cooked work together with @mcgregorlab.bsky.social, @posnienlab.bsky.social , @nuneslab.bsky.social sky.social and Saad Arif and the collaboration of @maikekittelmann.bsky.social, Fernando Casares & @laurensr.bsky.social and many other friends
rdcu.be/d8whP

04.02.2025 17:50 β€” πŸ‘ 36    πŸ” 19    πŸ’¬ 2    πŸ“Œ 2
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A scorpion embryo to brighten your day.

Purple: Pax2A. Yellow: Pax2B. Blue: nuclei.

29.01.2025 03:28 β€” πŸ‘ 30    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Postdoc @ evol-lab. A Leverhulme funded 3-year postdoc studying body shape evolution (through a sexual conflict lens) on Exeter's Penryn (UK) campus. Starts April 2025. Contact David Hosken @ U of Exeter for detail.

17.12.2024 09:40 β€” πŸ‘ 19    πŸ” 32    πŸ’¬ 0    πŸ“Œ 0
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Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila - Nature Changes in gene regulation are thought to be central to the evolution of form, but the molecular bases for such changes remain elusive. Analysis of the genetics of a wing spot that arose in the Drosop...

This one was always a favourite of mine during my PhD studies: www.nature.com/articles/nat...

21.01.2025 13:15 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Nigel Groome Studentship: Gene Regulatory Networks Driving Male-Female Genital Co-evolution at Oxford Brookes University Explore a Nigel Groome Studentship: Gene Regulatory Networks Driving Male-Female Genital Co-evolution. Apply today and discover more PhD opportunities at jobs.ac.uk.

PhD Opportunity: Last few days to apply to join my lab to explore the co-evolution of male and female genitalia in Drosophila. Feel free to DM me for more details! 🧬🐝 #PhDposition #EvolutionBiology #Genetics tinyurl.com/PhD-Drosophila

15.01.2025 13:23 β€” πŸ‘ 0    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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At Stockholm University, we are now starting a 2-year Master’s programme in Evolutionary Genomics!

Topics include population genetics, phylogenetics, molecular & genome evolution, DNA sequencing, bioinformatics, and palaeogenetics.

Please spread the word!

www.su.se/english/sear...

07.01.2025 16:44 β€” πŸ‘ 126    πŸ” 88    πŸ’¬ 0    πŸ“Œ 4
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Fruit flies have a new weapon to defend against parasitic wasps Fruit flies use a bacterial gene to protect against wasps, which threaten their larvae.The gene produces a toxin that kills wasp eggs.

www.earth.com/news/fruit-f...

27.12.2024 19:43 β€” πŸ‘ 11    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0

Fantastic work!

21.12.2024 16:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illumina…

Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr

20.12.2024 17:58 β€” πŸ‘ 145    πŸ” 64    πŸ’¬ 8    πŸ“Œ 5

Love this preprint, beautiful work

18.12.2024 22:22 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Associate Professor / Professor of Evolutionary Genomics - Job Opportunities - University of Cambridge Associate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.

Join us in Cambridge! This evolutionary genomics professorship (lecturer/reader level) has an emphasis on introgression and gene flow. If you study any aspect of evolutionary genomics then please apply! www.jobs.cam.ac.uk/job/49389/

18.12.2024 16:34 β€” πŸ‘ 62    πŸ” 59    πŸ’¬ 1    πŸ“Œ 1

Do you need to curate a Transposable Elements library for a new genome 🧬 or a new species πŸœπŸ¦ŸπŸ¦–? Try MCHelper.!
Very proud of my (small) contribution here. Gracias a @simonorozcoa.bsky.social y @gonzalezlabbcn.bsky.social!

genome.cshlp.org/content/earl...

13.12.2024 09:02 β€” πŸ‘ 7    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
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Evolution of piRNA-guided defense against transposable elements Transposable elements (TEs) shape every aspect of genome biology, influencing genome stability, size, and organismal fitness. Following the 2007 disco…

My graduate student shashank and I wrote this cool review on the evolution of transposon defense. Come for pirna cluster evolution stay for wild theories!

12.12.2024 23:43 β€” πŸ‘ 15    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0

@amberridgway is following 20 prominent accounts