Vojtech Dvorak

Reverse Proteolysis, Will You Look At That

www.science.org/content/blog...

OBS SPEAKER HIGHLIGHT👩‍🔬
How Skin Injury Primes Distant Immunity
🗣️ @mariemradhouani.bsky.social
@starkllab.bsky.social lab.bsky.social
@cemm-vienna.bsky.social @meduniwien.ac.at

📆 Thu, June 5, 11 pm ET
👉 Registration:
us02web.zoom.us/meeting/regi...

Can a biologist fix a radio?—Or, what I learned while studying apoptosis As a freshly minted Assistant Professor, I feared that everything in my field would be discovered before I even had a chance to set up my laboratory. Indeed, the field of apoptosis, which I had recent...

Even though this essay is supposedly a classic, I only discovered it a few days ago. It’s a great (short) read, indeed!

www.cell.com/cancer-cell/...

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria Systematic mapping of protein-ligand interactions is essential for understanding biological processes and drug mechanisms. Peptide-centric local stability assay (PELSA) is a powerful tool for detectin...

Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org
We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs.
📄 Read the full study: www.science.org/doi/10.1126/...
Let’s dive in 🧵 1/9

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...

🔬 Calling all PhD students & postdocs in chemistry/biology!
Join us at the Chemical Probes Hackathon 🧪:

🗓️ Feb 20, 2025 | 10:00–14:30
📍 Vienna, Austria

💡 Evaluate chemical probes w/ experts & improve global science 🌍.
🎓 Earn a Certificate of Attendance!

Learn more & register 👇

Kicking off the new year: A collaboration between @giuliosupertifurga.bsky.social and @alessiociulli.bsky.social using a transporter-focused genetic screens revealed that the efflux pump ABCC1/MRP1 restricts PROTAC sensitivity in cancer cells. Out now in @CellChemBiol www.cell.com/cell-chemica...