Daniel Zhen Ye Sin

Phages communicate across species to shape microbial ecosystems Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...

Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species.
Original idea from @albertomarina.bsky.social and, as usual, he was right.
www.biorxiv.org/content/10.1...

This work was done with the amazing @albertomarina.bsky.social lab. Big thanks to them! Go crosstalk RAHH!! 🗣️🔥🗣️🔥

Phages communicate across species to shape microbial ecosystems Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...

Good morning Phage [Ph]ans! I'm so stoked to share my first preprint with the @jrpenades.bsky.social lab! We show that phages can use the arbitrium system to crosstalk and regulate lysis-lysogeny, which has huge implications in how phages shape microbial communities!
www.biorxiv.org/content/10.1...

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

Incredible work!! Go check it out!

Virtual Virology is back - our first ever phage session. Do join us...

Intracellular competition shapes plasmid population dynamics Conflicts between levels of biological organization are central to evolution, from populations of multicellular organisms to selfish genetic elements in microbes. Plasmids are extrachromosomal, self-r...

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...

It’s a rare day these days when me and my boss are both at work! But it’s always wonderful when he’s here - he buy me clothes from NYC and he help me with preparing todays lab meeting on the weekend! Really grateful to have such an amazing D2D supervisor!

Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization https://www.biorxiv.org/content/10.1101/2025.02.11.637232v1