Angelika Lampert

Sodium channels and clinical pain: join the finale of worldwide sodium channel seminar series by Janneke Hoeijmakers on June 24! Still not enough of Nav research? Safe the date for the 2nd ww Nav channel conference Feb 4 to 6, 26 in Grindelwald CH⛰️. www.sodiumchannelseminars.org

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is now out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading our article!

Slow inactivation of the fast sodium channel will be the topic of our next worldwide sodium channel seminar by Shimon Marom Tuesday May 27th on "Adaptive, slow sodium channel inactivation: impacts on neuronal excitability".
www.sodiumchannelseminars.org for link and infos. 🧠 🎓

happening today, Tuesday 29th of April!

Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia The present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the por...

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Happening today! See you there!

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS

Join us in Berlin in September! It is going to be a great meeting for those of you interested in neuropathic pain, itch and related conditions! #Painresearch #PainScience 🧪🧠

Miriam Meisler will give our next #WWSC seminar on Feb 25th. Come and discuss Nav1.6 pathophysiology in epilepsy and treatment options: "Down-regulation of SCN8A by ASO or CRISPR-i prevents seizures in a GOF model".
Visit www.sodiumchannelseminar.org for info and link. See you there!

Thanks for the nice post!

Commentary: Christian Jorgensen @jorlab123.bsky.social discusses new study from Elhanafy et al. (https://buff.ly/4haX9PQ) which shows how identical mutations in the voltage sensing domain of sodium channels can yield differential functional effects. https://buff.ly/4jpCRUD

#IonChannels

Nociceptor sodium #ionchannels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology @JGenPhysiol https://buff.ly/4hku7gH

#openaccess

5/5 When stepwise reducing Nav1.9, we see the shoulder disappear. It fits to the observation that CMi-fibers have broad APs doi.org/10.1101/2024... and high expression of Nav1.9. So, the shoulder of nociceptor APs may well be supported not only by Nav1.8 but also - suprisingly strongly - by Nav1.9.

4/5 We model a CMi-fiber (sleeping nociceptor) and an Adelta-fiber. In both, Nav1.9 significantly contributed to the fast upstroke of the AP and also to the shoulder formation. We can also nicely mimic Nav related disease pathology, like erythromelalgia, in the model.

3/5 What is the role of all those Navs during AP generation? Thomas Stiehl created a computer model in which we fed HH models of Navs, generated on our patch data, according to their expression revealed by transcriptomic data published by @dianatavf.bsky.social @tedpricethepainguy.bsky.social

2/5 We find that – not surprisingly – Nav1.8 activates and inactivates at more depolarized potentials compared to all the other Navs. Nav1.9 – recorded by Enrico Leipold – and Nav1.5 activate at the most hyperpolarized potentials. Nav1.9 has hugh window currents, and prominent persistent currents.

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.

Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain The voltage-gated sodium channels (VGSC) NaV1.8 and NaV1.7 (NaVs) have emerged as promising and high-value targets for the development of novel, non-addictive analgesics to combat the chronic pain epi...

and a 3rd BOOM! for today: www.biorxiv.org/content/10.1... Again on VGNaCs. Navs enter the PROTAC era!! Well done Alex Chamessian and @robgereau.bsky.social

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH

#Biophysics #Neuroscience #IonChannels

Thank you Ted! As always quick in catching new papers - this one is actually one i am really excited about. Thread to follow.

Microbiome contributions to pain: a review of the... : PAIN oorganisms and the neuroimmune networks that drive pain in such diseases. More recently, microbiomes both inside and across the surface of the body have been recognized for driving sensory symptoms in...

check it out! our lab's first review paper is officially in print and was selected as an editor's choice at Pain! fun summary video in this link in case you don't feel like reading🦠💩🐁: journals.lww.com/pain/fulltex...

Tenure Track Assistant Professor of Anesthesiology The Department of Anesthesiology and Critical Care Medicine at the University of New Mexico Health Sciences Center in Albuquerque, New Mexico,...

Position at University of New Mexico in Anesthesiology: unm.csod.com/ux/ats/caree... I know that their surgery team has setup human DRG recovery and they are keen on an electrophysiologist who can help them to grow their work in human nociceptor neurobiology.

How could simulations elucidate Nav1.5 #ionchannel blockers mechanism? | Journal of General Physiology | Rockefeller University Press https://buff.ly/4gTs9Em

paywall 🙁

Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues.

www.cell.com/cell/fulltex...

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the

Excited to start the year with this paper with
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70

thank you @jansiemens.bsky.social !