Angelika Lampert

Köster, @lampertlab.bsky.social et al. characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. rupress.org/jgp/article/...

📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25

The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...

⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch

🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease.

🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/

#NaV #ionchannels #cardiacphysiology #scienceconference

@jgp.org @rupress.org

🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome.

🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community. Hugues Abriel and Angelika Lampert (@lampertlab.bsky.social) introduce the Special Issue (rupress.org/jgp/search-r...) illustrating the richness and continuing momentum of this field. rupress.org/jgp/article/...

This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

@jgp.org Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. From Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

Sodium channels and clinical pain: join the finale of worldwide sodium channel seminar series by Janneke Hoeijmakers on June 24! Still not enough of Nav research? Safe the date for the 2nd ww Nav channel conference Feb 4 to 6, 26 in Grindelwald CH⛰️. www.sodiumchannelseminars.org

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is now out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading our article!

Slow inactivation of the fast sodium channel will be the topic of our next worldwide sodium channel seminar by Shimon Marom Tuesday May 27th on "Adaptive, slow sodium channel inactivation: impacts on neuronal excitability".
www.sodiumchannelseminars.org for link and infos. 🧠 🎓

happening today, Tuesday 29th of April!

Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia The present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the por...

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Happening today! See you there!

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS

Join us in Berlin in September! It is going to be a great meeting for those of you interested in neuropathic pain, itch and related conditions! #Painresearch #PainScience 🧪🧠

Miriam Meisler will give our next #WWSC seminar on Feb 25th. Come and discuss Nav1.6 pathophysiology in epilepsy and treatment options: "Down-regulation of SCN8A by ASO or CRISPR-i prevents seizures in a GOF model".
Visit www.sodiumchannelseminar.org for info and link. See you there!

Thanks for the nice post!

Commentary: Christian Jorgensen @jorlab123.bsky.social discusses new study from Elhanafy et al. (https://buff.ly/4haX9PQ) which shows how identical mutations in the voltage sensing domain of sodium channels can yield differential functional effects. https://buff.ly/4jpCRUD

#IonChannels

Nociceptor sodium #ionchannels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology @JGenPhysiol https://buff.ly/4hku7gH

#openaccess

5/5 When stepwise reducing Nav1.9, we see the shoulder disappear. It fits to the observation that CMi-fibers have broad APs doi.org/10.1101/2024... and high expression of Nav1.9. So, the shoulder of nociceptor APs may well be supported not only by Nav1.8 but also - suprisingly strongly - by Nav1.9.

4/5 We model a CMi-fiber (sleeping nociceptor) and an Adelta-fiber. In both, Nav1.9 significantly contributed to the fast upstroke of the AP and also to the shoulder formation. We can also nicely mimic Nav related disease pathology, like erythromelalgia, in the model.

3/5 What is the role of all those Navs during AP generation? Thomas Stiehl created a computer model in which we fed HH models of Navs, generated on our patch data, according to their expression revealed by transcriptomic data published by @dianatavf.bsky.social @tedpricethepainguy.bsky.social

2/5 We find that – not surprisingly – Nav1.8 activates and inactivates at more depolarized potentials compared to all the other Navs. Nav1.9 – recorded by Enrico Leipold – and Nav1.5 activate at the most hyperpolarized potentials. Nav1.9 has hugh window currents, and prominent persistent currents.