MRC Weatherall Institute of Molecular Medicine

Researchers create first atlas showing cell interactions in lung fibrosis New study uncovers key immune cell interaction that could explain failed lung repair in idiopathic pulmonary fibrosis (IPF)

NEW: Study led by @imm.ox.ac.uk researchers maps key immune-epithelial cell interactions in lung fibrosis — opening doors to new therapeutic research. Published in @natcomms.nature.com this week 🧪

Learn more 👇

@ndm.ox.ac.uk | @oxfordbrc.bsky.social

Wellcome Discovery Award for Claus Nerlov Claus Nerlov, Professor of Stem Cell Biology, has been awarded funding from Wellcome to map the gene regulatory networks in blood cell production and seek new therapeutic targets.

🎉 Congratulations to Prof Claus Nerlov, who has been awarded funding from Wellcome to map the gene regulatory networks in blood cell production and seek new therapeutic targets 🩸

Read more 👇

@rdm.ox.ac.uk | @wellcometrust.bsky.social

New Study Links Cancer Stage to Strength of Antitumoral Immune Response in HR+ Breast Cancer The latest study from Tao Dong's Group in the MRC Translational Immune Discovery Unit has been published in Cell Reports Medicine.

NEW: Latest study from Tao Dong's Group links cancer stage to strength of antitumoral immune response in HR+ breast cancer 🧪

Read more 👇

@ndm.ox.ac.uk | @medsci.ox.ac.uk

NEW: @nature.com study, co-led by @akiversen.bsky.social (@ndcnoxford.bsky.social), maps infectious diseases across millennia 🧪

Learn more 👇

Making it Personal – Engaging the public through theatre Innovative public engagement project explores the intersection of cutting-edge science and the raw honesty of the stage.

Have you ever considered using theatre to connect your research with the public?

Ali Kay (@genomics-ali.bsky.social) from the @gorielylab.bsky.social at the MRC WIMM has co-led a project that utilised theatre to explore a couple’s experience of a genetic diagnosis in their child.

Read more 👇

Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome Key Points. Somatic preleukemic GATA1s mutations are acquired before birth in 25% of neonates with Down syndrome and are not acquired post-natallyRates of

NEW: Research led by Professors Irene Roberts and Paresh Vyas reports the outcome of the first-ever prospective study of newborn babies with Down syndrome, exploring why these babies and young children have such a high incidence of acute myeloid leukaemia caused by mutations in the GATA1 gene. 🧪

New tool allows researchers to track how mutations arise in tissues Researchers at the MRC Weatherall Institute of Molecular Medicine and the German Cancer Research Center (DKFZ) have developed a new method to analyse how our tissues evolve as we age.

NEW: Researchers at the MRC WIMM and @dkfz.bsky.social have developed a new method to analyse how our tissues evolve as we age, called SCIFER 🧬 🧪

Read more 👇

@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk

Celebrating science, collaboration and excellence at WIMM Day 2025 The MRC WIMM community gathered for its flagship annual event, WIMM Day, on Tuesday 24th June. Held at the Saïd Business School, the day showcased the breadth and impact of research across the institu...

WIMM Day 2025 brought our researchers together to share discoveries, swap ideas & celebrate success — from gene editing to immunotherapy to public engagement.

Catch the recap + award winners here:

Congratulations to the new RDM PIs 🎉 - all MRC WIMM researchers!

Always a pleasure to attend EHA Annual meeting. Well done to WIMM students presenting their work. And a good catch up with all! #EHA2025 @imm.ox.ac.uk

Congratulations to our DPhil student, @xinranhuang.bsky.social, on being awarded a poster prize today at the EMBO | EMBL The Ageing Genome symposium in Heidelberg! 🎉 We're so proud of you--well done!!!

#EESAgeing #PatelLab
@imm.ox.ac.uk
@kebleoxford.bsky.social

🚨🚨Paper out! 🚨🚨

Delighted to share our work, now published in ‪@natgenet.nature.com‬ 🧬!
shorturl.at/94s5S

We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n

Illustration: Hratch Arbach
🧵👇

New research reveals druggable target arising from chromosomal rearrangement in aggressive leukaemia Researchers at the University of Oxford have uncovered a potential new therapeutic target in a particularly aggressive and hard-to-treat form of leukaemia.

NEW: Researchers at the MRC Molecular Haematology Unit, led by @ckbrierley.bsky.social & @adammead.bsky.social, have uncovered a potential new therapeutic target in BP-MPN - a particularly aggressive type of leukaemia.
🧪🧬

Read more:

@oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk

A group of our researchers are rowing 100km (each!) in June to raise money for Bone Cancer Research Trust.

Show them some support below 👇

Image showing details for Digital Communications Officer role, including a salary range of £34982 - 40855 and an application deadline of 12pm on the 25th June 2025.

We're hiring! An exciting opportunity has arisen to join us as Digital Communications Officer 📹 💻

This role will work closely with our Comms & Public Engagement Officer to support the delivery of our communication strategy and produce in-house audio-visual content.

Apply here: bit.ly/4jIheOt

We're excited to be attending The Big Bang Fair (@bigbangukstem.bsky.social) next month!

Our stand - Targeted Therapies - will be led by researchers from the MRC Molecular Haematology Unit & will introduce students to gene editing & some of the challenges in developing cancer therapies 🧬

T cell responses to monkeypox play a part in protecting against infection A new study, led by researchers at the CAMS Oxford Institute in the Nuffield Department of Medicine and TIDU in the MRC Weatherall Institute of Molecular Medicine, has found that specific T cells could have an impact on the long-term protective responses to future infection.

NEWS: T cell responses to monkeypox play a part in protecting against infection

The study led by researchers at the ‪@ndm.ox.ac.uk‬ and @imm.ox.ac.uk has found that specific T cells could have an impact on the long-term protective responses to future infection.

www.medsci.ox.ac.uk/...

Congratulations to @agoriely.bsky.social on being awarded the Spinoza chair by @amsterdamumc.bsky.social 🎉

In June, Prof Goriely will give her Spinoza lecture on how new genetic mutations arise in the testes, their increase in frequency as men age, and how they can lead to serious genetic diseases.

Study identifies key immune structures in the gut that may drive coeliac disease | NIHR Oxford Biomedical Research Centre

Researchers have found structures of immune cells in the gut that may drive the response to gluten in people with coeliac disease and could provide a target for future therapies oxfordbrc.nihr.ac.uk/study-identi... @ndm.ox.ac.uk @oxfordpaediatrics.bsky.social @imm.ox.ac.uk @medsci.ox.ac.uk

Congratulations to former MRC WIMM Director Andrew McMichael on his election to the US National Academy of Sciences 🎉

Pint of Science Oxford Researchers from the University of Oxford share their discoveries with you.

Less than two weeks to go until @pintofscience.uk is back in Oxford (May 19–21)!

On May 20th, MRC WIMM researcher @abattacks.bsky.social will explain how organoids, or 'mini-organs', are a small solution to big problems!

For more information and tickets, visit: pintofscience.co.uk/events/oxford

Flyer for Hoffbrand's Postgraduate Haematology, 8th Edition

Our researchers Adam Mead, Graham Collins and Deborah Hay have edited the eighth edition of this seminal #haematology text book, published by Wiley. Intended as a reference work and guide to the latest research in the field.
www.rdm.ox.ac.uk/news/rdm-res...

@graham74gc.bsky.social

NEW from the Fairfax Lab (@bpfairfax.bsky.social):
🧪

Wellcome Career Development Award For Agne Antanaviciute Dr Agne Antanaviciute has won a Wellcome Career Development Award for her research investigating early-life immunity.

Congratulations to Dr Agne Antanaviciute, who has won a Wellcome Career Development Award for her research investigating early-life immunity. 🎉

Read more: www.imm.ox.ac.uk/news/wellcom...

@rdmoxford.bsky.social
|
@wellcometrust.bsky.social

We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below

New study reveals details of key immune mechanism An international collaboration, initiated by the Jackson Group at the MRC WIMM, has uncovered new information that could help in the development of drugs to block conditions such as autoimmunity and i...

NEW: International collaboration, initiated by the Jackson Group at the MRC WIMM, has uncovered new information that could help in the development of drugs to block conditions such as autoimmunity and inflammation. 🧪

Read more: www.imm.ox.ac.uk/news/jackson...

NEW: Paper out today in @naturecomms.bsky.social from @drakesmith-lab.bsky.social & Higgs Lab reveals an ancient connection between metabolic and transcriptional control of red blood cell production 🧪

Read more: www.imm.ox.ac.uk/news/ancient...

"We Are All Mutants" Researchers from the Goriely Lab and Centre for Personalised Medicine reflect on their experience of exploring genomics and ethics with A Level students in Southport.

Last month, a team of researchers from @gorielylab.bsky.social led an interactive educational workshop titled “We Are All Mutants” for two biology classes at King George V College in Southport.

Find out more in our latest blog post - www.imm.ox.ac.uk/about/blog/w...

David Jackson @imm.ox.ac.uk discusses a new intravital imaging technique by Cleary et al. (rupress.org/jem/article/...) enabling lung lymphatics and their participation in immune cell trafficking events to be visualized for the first time in mechanically ventilated mice rupress.org/jem/article/...

Wellcome Career Development Award For Sumana Sharma Dr Sumana Sharma has won a Wellcome Career Development Award for her research investigating receptors in T cells.

Congratulations to Dr Sumana Sharma (@sumanasharma.bsky.social), who has won a Wellcome Career Development Award for her research investigating receptors in T cells 🎉

Read more: www.imm.ox.ac.uk/news/wellcom...

@rdmoxford.bsky.social | @wellcometrust.bsky.social