Conrad Nieduszynski

New preprint🎉
Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated.

👉 doi.org/10.64898/202...

Kennedy Trust for Rheumatology Research (KTRR) Group Leader in Microbiome Studies (183704) We are seeking applications from an outstanding scientist to establish and lead a new research group in human microbiome science, advancing understanding of microbe–microbe and microbe–host interactio...

Hiring: Group Leader in Microbiome Studies! ✨

The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease.

Apply by 22 Dec.

www.ndorms.ox.ac.uk/jobs/kennedy...

Peptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham on FindAPhD.com PhD Project - Peptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham, listed on FindAPhD.com

💡 PhD student position at the University of Birmingham, UK. Fully funded by MRC AIM doctoral training programme. 4 years. Open to 🇬🇧 🇪🇺 & 🌎. DNA replication 🧬 . Collaboration with Prof Andrew Wilson (Chemistry). Deadline midday (GMT) 9 January 2026. Please share 😀👍

www.findaphd.com/phds/project...

Postdoctoral Researcher (Dr Miguel Montez) | John Innes Centre An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre.

📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project.

This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes

📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...

ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinase

We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social

Application Guidance | Doctoral Training Partnership Please follow our application guidance when applying to the programme. Candidates will submit an application through the University of East Anglia admissions system (link at the bottom of this page).

Closes 2 Dec 2025 - how to apply: biodtp.norwichresearchpark.ac.uk/how-to-apply...
Please share. Do reach out with any questions.

Picture of colleagues outside

Group picture in the institute

We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5

Engineering stable synthetic chromosomes 4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD

PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes.

buff.ly/l3dTmAf

#synbio

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10...

Congratulations Aykut & Alper!

📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social!

Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich.

buff.ly/327FNrX

#genomics #findaphd #AcademicSky

How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...

New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr

The EI Advanced Training team welcome delegates to the Earlham Institute for Norwich Nanopore Day.

Attendees networking during a break in the atrium of the Earlham Institute

Attendees networking during a break in the atrium of the Earlham Institute

Attendees networking during a break in the atrium of the Earlham Institute

Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬

Group Leader: Artificial Intelligence (AI) in Biology

📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology.

Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics.

🗓️ Applications close: 24 Oct
➡️ buff.ly/YRz3YLe

#machinelearning

Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis. Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis.
www.biorxiv.org/content/10.1...

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social

Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.

Single-molecule identification of replication fork pause sites around highly transcribed genomic loci using nanopore sequencing

Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication.

📄 Plenary session 4
🗓️ Wednesday, 23 July 2025
🕤 9:30am - 11:00am

From cooperation to conflicts – a complicated relationship between transcription and replication. A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....

Scientists look to biotechnology to improve crop resilience and nutritional value A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…

💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops."

A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.

Scientists look to biotechnology to improve crop resilience and nutritional value A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…

Modern agriculture faces significant challenges, from climate change to soil degradation and food security.

Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.

Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton.

tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans).
But outside those ranges? Some things happen.
1/3

Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social

Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today.

Starting point of DNA replication mystery solved The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.

💬 “When we looked at the replication start sites we’d identified, we discovered only 20% of them had been reported previously. The majority were newly discovered with this approach."

📃 Researchers use ultra #longreads to reveal #DNAreplication sites in the #humangenome.

‪@conradn.bsky.social