Christoph Handschin

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Hi Monica,

could you add me to Science feed please? Thanks!

Google Scholar: scholar.google.com/citations?us...

Biozentrum PhD Fellowships Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

The first time Charlie Chaplin used his voice in a film, he wielded it to forcefully condemn the rising forces of fascism around the globe.

Will we listen to his words today?

A female scientist in a lab coat is using a microscope to examine a sample.

In today's read from Function, APS CEO Scott Steen explains where we, and #physiology, go from here during this time "of unprecedented challenge for science in the United States." ow.ly/zTTT50Wj8bz #WeArePhysiology 🧪 @apspublications.bsky.social‬

Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer We are living through a moment of unprecedented challenge for science in the United States. A few months ago, as the Chief Executive Officer (CEO) of the A

Editorial by Scott Steen, CEO of the @apsphysiology.bsky.social

Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer

academic.oup.com/function/art...

The Breaking Point, Funding Uncertainty Threatens Scientific Innovation Federal research funding delays and policy shifts are putting science careers and innovation at risk.

From the @apsphysiology.bsky.social @apspublications.bsky.social

The Breaking Point: Funding Uncertainty Threatens Scientific Innovation

www.physiology.org/publications...

Some patriotic reflections on Independence Day Look at me. I’m the originalist now.

@theverge.com

www.theverge.com/policy/69730...

How The New York Times is (still) getting gamed by the right And blowing its credibility in the process.

@theverge.com

www.theverge.com/culture/7000...

Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response Endurance training is known to elicit numerous changes in skeletal muscle to enhance performance and function. Many of these adaptations are controlle…

"Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response" - our new manuscript describes the changes in chromatin accessibility in exercise (acute & training) associated with gene expression.
www.sciencedirect.com/science/arti...

#OpenAccess: Review from Physiological Reviews, Biomarkers of #aging: from molecules and surrogates to physiology and function

Regula Furrer and Christoph Handschin
🖱️doi.org/10.1152/phys...
#exercise #healthspan #longevity @unibas.ch‬

Bethesda Declaration — STAND UP FOR SCIENCE Support NIH Staff Now!

www.standupforscience.net/bethesda-dec...

US science is being wrecked, and its leadership is fighting the last war Facing an extreme budget, the National Academies hosted an event that ignored it.

arstechnica.com/science/2025...

This just in from @apsphysiology.bsky.social
"Early reports indicate that the Trump administration’s proposed FY 2026 budget would slash funding for the NIH by more than 40%, cutting the budget from $47 billion to $27 billion. The APS urges Congress to reject this catastrophic proposal..."

Biomarkers of aging: from molecules and surrogates to physiology and function | Physiological Reviews | American Physiological Society Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research on aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans has been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience, and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential antiaging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

Now out in the typeset, final version! #openaccess

"Biomarkers of aging: from molecules and surrogates to physiology and function"

@apspublications.bsky.social @apsphysiology.bsky.social @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch

doi.org/10.1152/phys...

Resist, eggheads! Universities are not as weak as they have chosen to be. Opinion: It’s time for public resistance.

"This moment calls out for moral clarity and resolve. It asks universities to take their mission in society seriously and to resist being co-opted by government forces."
@arstechnica.com
arstechnica.com/culture/2025...

Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle Regular physical activity induces a variety of health benefits, preventing and counteracting diseases caused by a sedentary lifestyle. However, the mo…

What the is early stress response in exercised #muscle for? At least for Klf5, this seems important to shape lipid homeostasis in the acute (fatty acid metabolism) and chronic (lipid synthesis) settings. All this and more in our new paper:

#myoblue

www.sciencedirect.com/science/arti...

Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

This and much more! This review is an extension of, and complementary to our previous commentary in NPJ Aging (doi.org/10.1038/s415...), and the discussion in our review in the Journal of Physiology @physoc.bsky.social (doi.org/10.1113/jp28...).

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Changes that could improve healthy aging.

8.) Our current health care setting fails to prioritize such measures. What could be done to improve the situation? On the level of the individual person, health care professionals, health insurance providers, society and politics. How could we pay for this?

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Various biomarkers of aging, with different degrees of clinical evidence.

7.) In contrast for physiological, functional and anthropometric biomarkers, solid and broad human data exist! E.g. #VO2max, body composition (muscle and #fat mass/distribution), #muscle force and power, activity levels, gait speed and other frailty markers.

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Molecular "clocks" and biomarkers of aging.

6.) How measure aging trajectories or "biological age"? Current state of molecular #biomarkers, e.g. #epigenetic marks, plasma proteomics or #telomere length.

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Modifiers of healthy aging with solid and broad data in humans.

5.) What does work? Interventions with solid data on human aging, #morbidity, #mortality and/or #longevity: physical activity, #sleep, #nutrition, #stress, social interactions, socioeconomic disparities, #climatechange and much more!

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Molecular and cellular hallmarks of aging, and the proposed drugs and interventions that could modify these.

4.) Proposed "#anti-aging drugs" and interventions in human aging, e.g. #rapamycin, #metformin, #resveratrol, but also #reprogramming, #rejuvenation, #caloric restriction. Potentially negative effects on other health-beneficial interventions (e.g. #exercise).

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Old (left side) and young (right side) mouse.

2.) How to study aging? E.g. Genetic diseases of "accelerated aging" (e.g. #progeria), (super-) #centenarians and geography (e.g. in a so-called #BlueZone).

3.) How might human aging differ from that in animals? What could this mean for the study of model organisms in this field?

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Anthropometric, functional and physiological hallmarks of aging.

1.) What is aging? An inevitable normal biological process? A disease that can be treated or even cured? In any case, aging is one of the strongest risk factors for many (mostly chronic diseases), e.g. #cancer, #neurodegeneration and #dementia, or #cardiovascular pathologies.

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Biomarkers of aging: from molecules and surrogates to physiology and function | Physiological Reviews | American Physiological Society Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research of aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans have been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential anti-aging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

Our magnum opus on everything related to #aging is out as a preprint in Physiological Reviews @apspublications.bsky.social @apsphysiology.bsky.social #openaccess. Great collaboration with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch.

doi.org/10.1152/phys...

Some teasers:
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Mike spotted this before the rest of us. 🫡

Publications from 2025 are shared more on Bluesky than on X/Twitter.

Dysferlin deficiency causes metabolic dysregulation, characterized by mitochondrial abnormalities and death signaling as well as elevated glucose uptake and excessive glycogen accumulation in muscle @biozentrum.unibas.ch @regula-furrer.bsky.social @c-handschin.bsky.social buff.ly/xMvVaxk

Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:

doi.org/10.1038/s415...

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