The awesome Kelpies at sunset in Falkirk, Scotland

Monoterpenoid fluorophthalimide IMiDs that lack human cereblon binding: synthesis and anti-proliferative, anti-angiogenic and anti-inflammatory activities Immunomodulatory imide drugs (IMiDs) designed on the backbone of thalidomide are highly effective in the treatment of multiple myeloma (MM). However, …

Delighted to share our latest collaborative research paper with my long term collaborators Nigel Greig and W. Douglas Figg showing Thalidomide-like monoterpenoid analogues, unlike classic IMiDs, lack cereblon binding and they have anti-angiogenesis actions.

www.sciencedirect.com/science/arti...

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ZPA experiment…. Carried out In chick limb buds where graft the ZPA from a donor limb into the anterior of a host limb bud which induces a mirror image handplate! 6-8 digits instead of 3-4. Amazing! 50th anniversary of this amazing discovery/observation is in 2026…..

Morton Mintz, Post reporter with a muckraker spirit, dies at 103 A pioneer in consumer affairs journalism, he helped expose the deformity-causing hazards posed by thalidomide, a once-popular drug for morning sickness.

The journalist who broke the Thalidomide story in the USA in 1962 sadly died today. Amazing life and journalist. #thalidomide

www.washingtonpost.com/obituaries/2...

More Tall Ships arriving at Aberdeen for the Tall Ships festival!

Five surprising facts about AI chatbots that can help you make better use of them Here are some of the lesser known facts about systems like ChatGPT.

Here are some of the lesser known facts about systems like ChatGPT.

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Joachim Goedhart to the left, text to the right 100 extraordinary biologists Joachim Goedhart As one of the most prolific authors on the Node, Joachim Goedhartwrote the Node’s most-read post 'Data Visualization with Flying Colors'. He is an Assistant Professor at the University of Amsterdam, the Netherlands, unravelling G-protein signalling networks in time and space in cells and tissues. #100biologists #biologists100

This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social

Thank you @kevinthiessen.bsky.social i will miss ZR! You have been brilliant for the community. Thank you.

Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration - Journal of Biomedical Science Background Traumatic Brain Injury (TBI) is a major risk factor for neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), with neuroinflammation playing a critical ...

Latest collaborative paper with my long-term collaborator Nigel H Greig. Demonstrating a new pomalidomide based compound to combat neuroinflammation.

jbiomedsci.biomedcentral.com/articles/10....

Useful tips from @scekker.bsky.social et al. 🐟

Love this pic from 2008 in Madrid. Some legends of developmental biology…. John Fallon, Lewis Wolpert, Marion Ros and Lee Niswander. Happy memories and miss John and Lewis so much.

Thalidomide: the drug with a dark side but an enigmatic future Thalidomide is notorious for causing death and disability but it – and its derivatives – are proving useful for conditions such as leprosy.

theconversation.com/thalidomide-...

Despite thalidomide’s dark past, researchers are investigating it as a potential COVID-19 treatment The infamous drug can inhibit the body’s inflammatory response, which is why researchers wonder if it can effectively treat COVID-19.

theconversation.com/despite-thal...

ERC to double allowance for researchers moving to EU The European Research Council (ERC) is doubling the relocation allowance it makes to researchers coming to the EU to take up one of its grants. At present it offers third-country researchers up to €1 ...

the ERC has added a million euro for researchers moving to Europe.

Embryonic Vascular Dysgenesis: The Origin of Proximal Femoral Focal Deficiency Background Proximal Femoral Focal Deficiency (PFFD) is the most proximal manifestation of a syndrome involving Congenitally Shortened lower Limbs (CSL), which also affects the fibula and midline met...

Delighted to share our latest paper on the origins of phocomelia - thru loss of blood vessels

onlinelibrary.wiley.com/doi/10.1002/...

However Thalidomide alters yolk sac vasculature despite the absence of detectable Cereblon complex gene expression. Suggesting thalidomides antiangiogenic action may be independent of Cereblon.

Cereblon E3 Ligase Complex genes are expressed in tissues sensitive to thalidomide in chicken and zebrafish embryos but are unchanged following thalidomide exposure. Thalidomide is an infamous drug used initially as a sedative until it was tragically discovered it has highly teratogenic properties. Despite this it …

Delighted to share our latest research publication. “Cereblon E3 Ligase Complex genes are expressed in tissues sensitive to thalidomide in chicken and zebrafish embryos but are unchanged following thalidomide exposure”

www.sciencedirect.com/science/arti...

Farewell #biologists100

What an amazing meeting. The pure joy of discovery & wonder

Thank you to @bscb-official.bsky.social @bsdb.bsky.social @sebiology.bsky.social @biologists.bsky.social for organising!