Tim Humphrey's Avatar

Tim Humphrey

@humphreylab.bsky.social

Chromosome Integrity Group, Genome Damage and Stability Centre, University of Sussex.

366 Followers  |  269 Following  |  5 Posts  |  Joined: 14.11.2024  |  1.5368

Latest posts by humphreylab.bsky.social on Bluesky

Sorry to hear that- poor Laurence!

05.10.2025 12:22 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

Delighted to wave the flag for @gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing.
@rhysmorganlab.bsky.social

29.09.2025 20:26 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
Preview
Research Technician – Protein Biochemistry at University of Sussex Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

🧬πŸ§ͺ A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

πŸ“… Deadline: 29th September 2025.

πŸ™ Please share with anyone who might be interested.

09.09.2025 08:35 β€” πŸ‘ 6    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

01.09.2025 06:58 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
Preview
DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

03.09.2025 15:13 β€” πŸ‘ 11    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
Preview
DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: β€œDNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

03.09.2025 15:59 β€” πŸ‘ 39    πŸ” 19    πŸ’¬ 7    πŸ“Œ 1

Congratulations Uli and colleagues. Great work!

03.09.2025 16:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Emma Whitelaw Publication Award β€” Australasian Epigenetics Alliance

🧬 The 2025 Emma Whitelaw ECR publication award is now open!

Full T&Cs and application form are on the AEpiA website www.aepia.org.au/emma-whitela...

We can't wait to see the exciting research that has been published over the last year!

#epigenetics #ECR #research #AEpiA

25.08.2025 02:35 β€” πŸ‘ 4    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
Post image

Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to β€” on Brighton seafront, as part of Soapbox Science 2025 β€” a public outreach platform that promote women and non-binary scientists and the science that they carry out. β€ͺ@soapboxscience.bsky.social‬

23.06.2025 10:38 β€” πŸ‘ 14    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
DNA Damage and Replication Stress Checkpoints | Annual Reviews DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...

Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer.
doi.org/10.1146/annu...
@layates.bsky.social @crick.ac.uk @washu.bsky.social

24.06.2025 08:41 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Preview
BBC News, South East covers Words from the Waiting Room. β€” Sussex Cancer Research Centre Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...

Exciting to see SCRC Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield, highlighted on BBC news.
"Words from the Waiting Room offers cancer patients, survivors, and supporters a safe environment to express themselves"
sussexcancer.org/news/bbc-new...

25.03.2025 11:12 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Post image

Congratulations to Dr Stephen Robinson for launching the Sussex Brain Tumour Research Group.
@sussexcancer.bsky.social

11.03.2025 18:53 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Preview
Updates from the Sussex Cancer Research Centre on World Cancer Day. β€” Sussex Cancer Research Centre The theme of World Cancer Day 2025 is β€œUnited by Unique”, which places people at the centre of care and their stories at the heart of the conversation. Today the Sussex Cancer Research Centre (SCR...

It is #WorldCancerDay
We are excited to announce our funded research projects, a new community engagement strategy, creative award winners, and interviews.

sussexcancer.org/news/announc...

@bsmsmedschool.bsky.social @sussexuni.bsky.social @uniofbrighton.bsky.social @eshtnhs.bsky.social

04.02.2025 07:01 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
Preview
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

03.01.2025 09:30 β€” πŸ‘ 29    πŸ” 10    πŸ’¬ 1    πŸ“Œ 0
Post image

Today we celebrate our inspirational co-director Professor Melanie Flint m as she gives her inaugural lecture @brightonuni.bsky.social
An incredible scientist, leader, mentor, and all around amazing person.

04.12.2024 20:21 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Post image

Co-directors @humphreylab.bsky.social and @siftw.bsky.social were at Parliament today, celebrating 20 years of Brighton and Sussex Medical School, and working to make sure cancer research is at the centre of the next 20 years. @sussexuni.bsky.social @brightonuni.bsky.social

21.11.2024 00:18 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Great to join you here today and looking forward to some blue sky science chat!

14.11.2024 10:08 β€” πŸ‘ 9    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

@humphreylab is following 20 prominent accounts