Jess Frith

Thanks to all our lovely collaborators- with so many different aspects, and parts to get right, this was truly a collaborative and interdisciplinary effort!

@forsythelab.bsky.social
@vinhtruong.bsky.social
@drtinytaps.bsky.social
@choilab.bsky.social

Beyond this, the system holds great potential for studying any situation where matrix stiffness changes, such as in tissue development, fibrosis or cancer.

This hydrogel system allows for safe and reversible control of substrate stiffness using visible light (not UV!). We investigated the dynamics of MSC mechanosensing and discovered that "old" cells are far less able to react to a dynamic environment than "young" cells.

How did shining blue and green light on our cells help us discover differences in aging?

You can find out in our new paper led by PhD student Aafreen Ansari "A Visible Light-Responsive Hydrogel to Study the Effect of Dynamic Tissue Stiffness on Cellular Mechanosensing"

doi.org/10.1002/adfm...

Now officially past PhD confirmation time- Brendan did a fabulous job explaining his work developing new hydrogels to study colorectal cancer biology
#biomaterials #organoids #PhD

Final Call for Early Bird Registration – #ASBTE2025

Member registration: $880.00
Non-member registration: $1,050.00
Student and ECR registration: $580.00

Don’t miss your chance to save! Register now before the earlybird deadline this Friday 21 March 2025.
asbte2025.com.au/registration/

Late-Breaking Abstract Submission NOW OPEN for #ASBTE 2025!

The Late-Breaking Abstracts offer an opportunity to present innovative advancements that have developed after the standard submission deadline.

📅 Submission Deadline: Monday 10 March 2025
🔗 Submit now: asbte2025.com.au/abstract-sub...

Lots more to dig out of this data- but for MSC fans it provides food for thought on what an MSC really is, while details of the secretomes can help us decide which MSCs may be best suited for different clinical applications.

MSC source also matters: iMSCs were more consistent than tissue-derived MSCs. The “younger” umbilical cord and iMSCs secreted factors that favour proliferation and telomere maintenance, while “older” bone marrow and adipose MSCs were better at matrix secretion.

We found that inflammation triggers a shift from ECM secretion to immunomodulatory proteins, and importantly, iMSCs (from iPS cells) respond just like tissue-derived MSCs—showing that fundamental MSC properties are retained.

Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing npj Regenerative Medicine - Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing

MSCs exert their therapeutic effects via secreted factors but which MSC source is best & how do inflammatory cues alter the secretome and its effects?

Our latest paper profiled the secretome of different MSC types under resting and inflammatory conditions to answer these questions👇

rdcu.be/d8ypA

#ASBTE2025 has received over 220 abstracts from 10+ countries, covering a diverse range of cutting-edge topics! The enthusiasm and innovation from our community are truly inspiring.

📢 Save the date! Abstract outcome notifications will be announced on February 7, 2025—stay tuned!

#ASBTE2025

Calling all PhD students in Biomedical Engineering and Tissue Engineering! Submit your abstract to ASBTE25 now and take your research to the next level!
Deadline: 17 January 2025
🔗 Submit here: asbte2025.com.au/abstract-sub...

#ASBTE2025 #PhDLife #ResearchOpportunities #Networking

careers.pageuppeople.com/513/cw/en/jo...

One week to go! Applications to join our team as a senior postdoc close on 12th Jan.

If you have experience in hydrogels, bioprinting/fabrication & cell biology, are keen to develop your research and teaching skills, and want to join a friendly team in Melbourne check it out!

⏰ #ASBTE2025 Abstract Submission Deadline Extended!

The abstract submission deadline for #ASBTE2025 has been extended to 17 Jan 2025!

Don't miss out on this chance to share your work with leaders in biomaterials science and tissue engineering

asbte2025.com.au/abstract-sub...

@asbte.bsky.social

Join our team!
We are looking for a senior postdoc to develop new hydrogels for direct laser writing and apply them to study cell mechanics. Also an opportunity for mentoring in teaching and leadership. Applications due 12/1/25 careers.pageuppeople.com/513/cw/en/jo...
#biomaterials #mechanobiology

In Singapore this week for #ICBME24- Aeolus did the group proud presenting his work on a new system for intervertebral disc regeneration, including some exciting results on how to keep MSCs repairing the disc rather then becoming inflammatory in the injured tissue.

The ASBTE has joined blusky- follow if you want to keep up with the best of biomaterials and tissue engineering in Australia and New Zealand!

As the year comes to a close, don’t forget to add #ASBTE2025 to your to-do list!
Submit your work for the 29th Annual Conference of the ASBTE, April 2025, in Brisbane, Australia.
Deadline: 31/12/24
Submit here: asbte2025.com.au/abstract-sub...
#ASBTE2025 #Biomaterials #TissueEngineering

We’ve been connecting engineers and biologists via the Engineered Biological Models & Systems Research Node. At our end of year showcase I was blown away by the quality of the talks, discussions and collegiate atmosphere. Some great things happening in this space!
@monashorganoids.bsky.social

First post- a photo of the team celebrating successful FYP and honours projects for Josh and Julian.