BvK LaB

BvK LaB is ready to do exciting science in our new place with a great team! 🧫🧪⚛️

BvK LaB was at DESY, Hamburg, Germany DESY for a workshop: Bio-SAXS Beamline at SESAME | Synchrotron-light for Experimental Science and Applications in the Middle East, held in early Februrary, with full of scientific discussions, inspirations, and networking

Now available: the Proceedings of the 2024 @ccpem.bsky.social em Spring Symposium, including a review of the first ten years of the Symposium: journals.iucr.org/special_issues/2025/CCPEM2024/

View all of the Proceedings at journals.iucr.org/d/services/ccpem

Cryo-EM structure of the FtsH periplasmic domain reveals functional dynamics www.biorxiv.org/content/10.1101/2025.10.03.679995v1 #cryoEM

Cryo-EM analysis of multiple proteins in a single purified sample This study aimed to investigate how certain proteins in E. coli work together to ensure that membrane proteins are properly inserted, folded, or degraded. The focus was placed on a potential complex f...

Kudos page of our article. Take a look..
www.growkudos.com/publications...

Off-target structural insights: ArnA and AcrB in bacterial membrane-protein cryo-EM analysis This study highlights that cryo-EM can reveal structural information beyond the intended target, and that overexpression of membrane proteins involved in quality control may lead to the co-purificatio...

It is now published at @actacrystd.iucr.org journals.iucr.org/d/issues/202...

Off-target structural insights: ArnA and AcrB in bacterial membrane-protein cryo-EM analysis pubmed.ncbi.nlm.nih.gov/40927951/ #cryoEM

Thanks for your comment! This research study led us to many surprising findings

I've also purified ArnA by mistake (who hasn't?). Did mass spec before plunging it though, so never got this nice structure :)

Congratulations! Beautiful structures and very hard work

Structural biology was on the stage in the beginning of COVID with the spike protein structures on TV screens now the stage is yours mitochondria

This morning, I wandered around the medical suppliers and tried to find a piece for our project, then I improvised something with the materials we had on hand-so, if you're solution-oriented and take ownership of your work, you solve it.. I hope you don't lose your excitement for doing science!

Dedicated my talk at the opening evening of Biophysical Society proton meeting to Karen Davies.
Karen's work shaped the field of bioenergetics from solving the horizontal subunit-a of ATP synthase to the structures of photosynthetic CI and more. She was a brilliant scientist, mentor and communicator

Just returned from an incredible visit to South Korea as part of our bilateral scientific project between Türkiye and Korea! with Seoul National University, funded by TÜBİTAK. I had the privilege of visiting several leading research institutions, IBS, KAIST, KBSI, and Chungnam National University

BvK LaB group picture 2025 from the traditional Lake Eymir, Ankara walk. This year, two members graduated as MSc and PhD. Two students, one MSc and one PhD, have joined. Two interns have completed their internship. We are excited for the new term full of science!

Back from the ISDB,
Clearly my presence in the lab was missed!

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT!

Course website: meetings.embo.org/event/25-bio...

Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social

Location: www.ibg.edu.tr

Come and visit our poster at TP659 #ASMS2025

Off-Target Structural Insights: ArnA and AcrB in Bacterial Membrane Protein Cryo-EM Analysis Membrane protein quality control in Escherichia coli involves coordinated actions of the AAA+ protease FtsH, the insertase YidC, and the regulatory complex HflKC. These systems maintain proteostasis b...

ArnA and AcrB were copurified and structurally resolved within the cryo-EM sample of the overexpressed membrane protein complex, FtsH and YidC. Our study reveals interesting findings and confirms the power of #cryoEM technique.

In Baltimore, Maryland for #ASMS25 to present our XL-MS studies, explore exciting research in mass spectrometry, and meet great scientists from all over the world.

I will be at Baltimore, MD, US next week for #ASMS2025 to present XL-MS data of YidC interactions with other partners involved in the bacterial membrane biogenesis and quality control, a part of our TÜBİTAK 2232 project. Please find our poster at #TP659 on Tuesday

The versatile role of YidC in membrane protein biosynthesis and quality control Membrane proteins are essential for bacterial survival, facilitating vital processes such as energy production, nutrient transport, and cell wall synt…

Mehmet's first first-author publication! A comprehensive review on YidC, its evolution and structure, membrane protein biosynthesis and quality control

How a small but mighty protein protects a life-sustaining enzyme Details of how the FeSII protein protects the nitrogenase enzyme.

Nature News @nature.com mentioned about our latest research on FeSII, related to recently published two nitrogenase-FeSII structures

The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap The Azotobacter vinelandii FeSII protein forms an oxygen-resistant complex with the nitrogenase MoFe and Fe proteins.

Shethna protein II (FeSII), known as a conformational protector of nitrogenase against oxygen has a swapped domain in the crystal structure. Our study opens a window of new aspect in nitrogenase research

Structural proteomics of a bacterial mega membrane protein complex: FtsH-HflK-HflC Recent advances in mass spectrometry (MS) yielding sensitive and accurate measurements along with developments in software tools have enabled the char…

Mass spectrometry based structural elucidation of a bacterial mega membrane protein complex involved in quality control. Our study also gives a complete workflow for XL-MS analysis from either purified protein or cell membrane by using 5 different commonly used XL-MS software #xl-ms #proteomics

Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction #carbonfixation #proteindynamics #proteincrystallography www.sciencedirect.com/science/arti...

Sample Preparation for Electron Cryo-Microscopy of Macromolecular Machines High-resolution structure determination by electron cryo-microscopy underwent a step change in recent years. This now allows study of challenging samples which previously were inaccessible for structu...

"State of the art and developments in Cryo-EM sample preparation methods for macromolecular machines" described in our book chapter #cryo-em #structuralbiology #membraneproteins #proteinstructure

Tissue, serum, and saliva sampling for proteomic analysis Proteomics is the comprehensive analysis of all the proteins in a biological sample. It is a powerful approach that can be used to discover diagnostic…

Our book chapter where we comprehensively explain sample preparation methods for proteomics analyses in various matrices

Brings back fond memories of my PhD supervisor complaining about all the money I was wasting on biobeads during nanodisc and proteoliposome reconstitution

BvK LaB (@bvk_lab) / X BvK LaB (@bvk_lab) / X

We are now on @bsky.app please find us with the same name @bvklab.bsky.social as in x.com/bvk_lab