Kiwook

GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.

Congrats, @christophschneider.bsky.social and your team! It’s a beautiful and fantastic study!
GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation | Science Immunology www.science.org/doi/10.1126/...

Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry - Nature Reviews Immunology White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.

Highlight of a study by Teruyuki Sano and team in @nature.com revealing potential mechanisms by which commensal-specific T cells can contribute to extraintestinal inflammation
#immunosky #microsky #neurosky

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Big congratulations, Teruyuki Sano and his team on their publication in @nature.com ! It was great to collaborate this wonderful study with his team.
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

It's a beatiful lymphatic work entitled "Increased CSF drainage by non-invasive manipulaton of cervical lymphatics" @nature.com

Big congrats, Dr. Gou Young Koh and his team!

www.nature.com/articles/s41...

Online now: A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses

Gut dysbiosis from high-salt diet promotes #glioma via propionate-mediated TGF-β activation, say Chae Won Kim, Hyun-Jin Kim, Heung Kyu Lee and colleagues (Korea Advanced Institute of Science and Technology): rupress.org/jem/article/...

#TumorImmunology #SolidTumors #MucosalImmunology #Microbiome

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼
www.cell.com/immunity/abs...

🚨 Dedicated BSky account for EMDS2025 launched

Please share far and wide.

Follow @emds2025.bsky.social for all updates on the EMDS2025: Scotland Edition

We have an amazing line up of speakers and are excited to welcome all of you to bonnie Scotland in September!
@britsocimm.bsky.social

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice Brains of aging mice harbor rare monocyte-derived microglia (MoMg) that are transcriptomically indistinguishable from yolk-sac-derived cells. MoMg are targets of clonal hematopoiesis (CH) and, hence, ...

Three monocyte-derived Microglia/BAM papers in Immunity(@cp-immunity.bsky.social) plus one cell reports paper! Congrats for all authors and Dr. Steffen Jung (@steffenjung.bsky.social)!

cell.com/immunity/ful...
cell.com/immunity/ful...
cell.com/immunity/ful...
plus
www.cell.com/cell-reports...

It's hard to imagine that Jeongseok will no longer be part of your lab. He has grown tremendously as a scientist under your mentorship. Now, it's an exciting time for him to begin building an independent career. He will thrive at UNIST, one of top research institute in Korea. it's a well-deserved.

Congratulations, Steffen and your team! 🎉🎈🎊🍾
It’s truly amazing and this study will expand our understanding of microglia, in particular monocyte-derived microglia (MoMG)!

Great graphic summary! Thanks, Alex! You have fully understood our paper! 😍🤩

Thank you, Dr. Zanoni!

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you!
www.cell.com/immunity/ful...

It was a truly wonderful #EMDS2024 meeting.
Hope to see all of you next year in Edinburgh with a great organizer, @bainlab.bsky.social

Venetia Bigley had a wonderful talk on human IRF8 mutation and human DC3 subset at day 3 of #EMDS2024

Great time with EMDS colleagues
#EMDS2024