@drbarrymbradford.bsky.social
Prion disease researcher (Lecturer) at The Roslin Institute, The University of Edinburgh.
A single case of atypical #BSE has been confirmed on a farm in Essex today. The fast identification of the disease is testament to a robust veterinary surveillance system that is effective in detecting potential risk.
Read our statement.
www.bva.co.uk/news-and-blo...
expert reaction to an atypical case of BSE detected on a farm in Essex
www.sciencemediacentre.org/expert-react...
Something to keep me busy ๐
16.01.2025 15:06 โ ๐ 1 ๐ 0 ๐ฌ 1 ๐ 0Lab & mind switched off, time to enjoy the festive break and refresh for 2025. What new things will we discover?
20.12.2024 15:06 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
King's College London is seeking a Research Assistant to support study co-production and delivery of the 'Dementia Community Research Network'. Closing date: 5th January.
www.dementiaresearcher.nihr.ac.uk/job/research...
โผ๏ธ SAVE THE DATE
The next EMDS Meeting will take place from 16-18th Sept. 2025 in majestic Edinburgh ๐ด๓ ง๓ ข๓ ณ๓ ฃ๓ ด๓ ฟ. If you love macs, monos &/or DCs, or just want to learn more about them, THIS is the meeting for you.
Space limited - so watch out for details.
@britsocimm.bsky.social
Mucosal Immunology Winter Workshop;
โ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธโ๏ธ
January 24th
School of Infection & Immunity University of Glasgow
FREE to register, limited spaces
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
This PhD project, with Iris Mair Amy Pedersen and myself looks at the interactions between microbiota and immune regulatory cells and pathways at barrier sites. It includes fieldwork with wild mice on the Isle of May. www.findaphd.com/phds/project...
โญNEW PUBLICATIONโญ
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
@drbarrymbradford.bsky.social
Read the full publication below โคต๏ธ
https://buff.ly/3VsbbE6
Neuroscientists: please consider following the BNA @britishneuro.bsky.social - a professional society that supports neuroscience and neuroscientists
09.12.2024 09:23 โ ๐ 21 ๐ 13 ๐ฌ 0 ๐ 0
In the late 1980s, before anyone knew how Abeta was made, Wisniewski hypothesized that microglia made plaques because TEM showed amyloid in communication with microglial ER. Something to this I suppose? Maybe endosomes, not ER? Iโm not a cell biologist. www.nature.com/articles/s41...
07.12.2024 17:04 โ ๐ 10 ๐ 2 ๐ฌ 2 ๐ 0
Microscopy image of a prion infected brain stained with hematoxylin and eosin to reveal the sponge-like holes (spongiosis) characteristic of prion disease
Prion spongiosis: the sponge-like appearance of #prion affected brain tissue when viewed under a microscope. Resulting from the formation of tiny, round vacuoles (holes) in the neuropil (the dense network of neurons and glial cells) and within neuronal cell bodies.
05.12.2024 10:42 โ ๐ 10 ๐ 1 ๐ฌ 0 ๐ 0Beautiful!
05.12.2024 10:33 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0Job opportunity here in lovely Edinburgh with amazing colleagues in the Lothian Birth Cohort 1936 team!
The closing date is Monday 13th of January 2025.
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
![Fluorescent microscopy image of Chronic Wasting Disease prions florid (flower-like) amyloid plaque in the brain [bright green]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:vmrrat62drkiuqbd3knhvxws/bafkreieeyc5o4hvrmge2sh6ctuzhh6xxhyzk5a5jd5xeta7rnjvf3edcfy@jpeg)
Fluorescent microscopy image of Chronic Wasting Disease prions florid (flower-like) amyloid plaque in the brain [bright green]
Amyloid meaning starch or cellulose like described by Virchow (1851). Ordered protein aggregates that bind certain compounds such as Thioflavin. Shown here fluorescent #microscopy image of Chronic Wasting Disease #prions florid (flower-like) #amyloid plaque in the brain [bright green]
04.12.2024 10:33 โ ๐ 3 ๐ 0 ๐ฌ 0 ๐ 0All work and no play makes science dull.
All work and no play makes science dull.
Gehirnfรคule
02.12.2024 15:16 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0Congratulations Juan!
28.11.2024 11:37 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
#Immunosky #neuroskyence our team is expanding and weโre recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
27.11.2024 05:05 โ ๐ 20 ๐ 14 ๐ฌ 1 ๐ 0Please add me. TIA
26.11.2024 09:23 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0Results of another great collaboration including work from our PhD student looking at microglia role in pron disease #neurodegeneration: The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology doi.org/10.1016/j.nb...
26.11.2024 09:20 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Photo of researchers interacting beside a poster display
Photo of 3D printed brains of different sizes
Photo of people looking at an artwork on display
Microscopic image of a neuron
Hi Blue Sky folks ๐
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Image reads โGlobally United for Prion Disease Awareness. 12th November 2024 International CJD Awareness Day. #cjdAwareness #PrionDiseaseAwarenessโ It was created by the CJD International Support Alliance.
A graphic of an umbrella with the three main types of prion disease underneath. Prion Disease A rare, rapidly progressive and always fatal neurological disease. Sporadic CJD (sCJD) has no known cause and occurs randomly with a lifetime risk of 1:6,000. sCJD accounts for approximately 85%-90% of all cases of prion disease. Atypical forms of sCJD account for less than 1% of all sporadic cases. These include Variably Protease Sensitive Prionopathy (VPSPr) and Sporadic Fatal Insomnia (sFI). Acquired prion disease is the rarest cause representing less than 1% of all prion diseases. Iatrogenic or medically acquired CJD from contaminated surgical instruments, corneal transplant, dura mater graft, and human pituitary hormone treatment for infertility and short statue. Variant CJD (vCJD) acquired from exposure to BSE through consumption of contaminated beef or blood plasma transfusion. Genetic Genetic prion disease accounts for approximately 10-15% of all prion disease cases. Genetic prion disease includes Genetic CJD (gCJD), Gerstmann- Strรคussler-Scheinker disease (GSS) and Fatal Familial Insomnia (FFI). DNA can be tested to identify if an individual carries a mutation for prion disease. The vast majority have an autosomal dominant pattern - if one parent carries a mutation for prion disease there is a 50-50 chance for each child to inherit the gene. www.cjdisa.com
12th November is CJD Awareness Day.
Creutzfeld Jacob Disease is a prion disease. A protein misfolds in the brain which causes ongoing damage. It is 100% fatal and most people die within six months of onset of symptoms.
#cjdAwareness
#PrionDiseaseAwareness
#GloballyUnitedForPrionDiseaseAwareness
