Brain Communications

Özbay et al. demonstrated that intranasal administration of peptides targeting melanocortin 4 and ghrelin receptors can modulate food intake in mice. Their study shows that selected peptides successfully reach the hypothalamus 👉 buff.ly/w5Rnixy

Cody, et al., use temporal modelling to show that Alzpath and Lilly plasma p-tau217 can provide individualized estimates of p-tau217 positive age and time 👉 buff.ly/1XxoCFl

#Alzhimers

Perivascular space dysfunction has been proposed to be a pathogenic mechanism in amyotrophic lateral sclerosis (ALS). Hsueh et al. reported that changes and dysfunction in imaging parameters may contribute to the clinical manifestations of ALS 👉 buff.ly/eaS1Pkv

Cabello Fernandez et al. report that two psychoeducation interventions (cognitive versus affective) tailored to cognitive, functional and psychological difficulties in Long COVID were well-received and beneficial 👉 buff.ly/GWe7HMg

#COVID

Serum glial fibrillary acidic protein, neurofilament light chain and Growth/differentiation factor-15s were increased in the chronic stage of Leber hereditary optic neuropathy and autosomal-dominant optic atrophy 👉 buff.ly/1a3qEpb

Nestor et al. deployed a portable, handheld neuronavigation-guided low-intensity ultrasound system in a single-arm safety and feasibility study involving 12 Alzheimer’s participants treated 4× with 30–100 sonications at a 1.95 MPa dose 👉 buff.ly/ryCPeLd
#Alzhimers

Helena Verhelst and Emma M. Karlsson report that developmental dyslexia is associated with inconsistent and regionally atypical hemispheric lateralization for language, rather than weaker or absent asymmetry 👉 buff.ly/APFl1WX
#dyslexia

Diachenko et al. report an electroencephalography-based marker for tracking early-stage hyperexcitability in Alzheimer's disease. In an Alzheimer's mouse model, recordings revealed early-stage frequency-specific shifts towards excitatory dominance 👉 buff.ly/dpxqHbZ

Pisano et al. show neurite orientation dispersion and density imaging diffusion magnetic resonance imaging reveals distinct microstructural patterns in dementia variants, developing a machine-learning model that classified subtypes with 97.3% accuracy 👉 buff.ly/S0tDJBn

Vidinopoulos et al. (2025) report that mechanical ventilation for 24 h preceded by intratracheal endotoxin exposure amplifies inflammatory proteins systemically and causes inflammation of brainstem respiratory-related centres in preterm foetal sheep 👉 buff.ly/928YYNy

This study demonstrates that former American football players showed localized shape alterations in the hippocampal, amygdala and selective thalamic changes relative to controls.
Read at 👉 buff.ly/4NDfN6B

Toker and Monti report that rare causes of disorders of consciousness, including infections, autoimmune conditions and neurodegenerative diseases, target the same brain circuits as common causes.
Read at 👉 buff.ly/pyeQKIJ

Capitani et al. review the relationship between the Human Leukocyte Antigen system and Alzheimer’s disease, presenting five perspectives; genetic association, HLA class I in the brain, infection hypothesis, antigen presentation and T-cell responses 👉 buff.ly/6iytQ4N
#Alzhimers

Zhu et al. report that in cognitively unimpaired adults, sleep architecture is differentially associated with CSF and plasma biomarkers. These associations were moderated by APOE ε4 status 👉 buff.ly/2QP8Npb #Alzhimers

Rasmussen et al. report that riociguat, a soluble guanylate cyclase stimulator, induces cranial vasodilation and headache in healthy adults. These findings suggest that guanylate cyclase signalling may play a role in headache pathogenesis 👉 buff.ly/2KVbAxS

Okochi et al., found that female SLC9A6 heterozygotes cause novel Parkinsonian syndrome and tauopathy. This finding was recognised by OMIM and registered as a novel degenerative disease: NDPACS. This review outlines the disease concept of NDPACX 👉 buff.ly/hqzz67A

Garvey et al. report that in a cohort of patients with sensory predominant axonal neuropathies, the presence of chronic cough with either small nerves on ultrasound was associated with the RFC1 gene expansion found in CANVAS 👉 buff.ly/eZ4b9dH

The Early Career Researcher Paper Prize nominations close today! Submissions after 11:59 pm GMT will not be accepted.
#ecr #braincommunications
Link to form: buff.ly/8DWT8TV
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Bennett et al. discovered hidden complex repeat expansions in the gene MARCHF6 in two families with rare forms of epilepsy. These expansions were missed by current repeat expansion testing but were revealed by a new analysis approach 👉 buff.ly/OCDxeYs #epilepsy

The Early Career Researcher Paper Prize nominations close in less than 3 days! Submissions after 11:59 pm GMT on the 31st will not be accepted.
#ecr #braincommunications
Link to form: buff.ly/8DWT8TV
Find out more at: buff.ly/5WfBuCR

Rasgado-Toledo, et al. reported sex-dependent and region-specific effects of combined ethanol exposure and chronic stress on both the rat brain volume and functional networks, affecting its plasticity during neurodevelopment.
Read at 👉 buff.ly/EOqLUwf
@jalilrt.bsky.social @dangeles.bsky.social

Have you read an outstanding paper published in Brain Communications during 2025? Nominate it for the Early Career Researcher Paper Prize! Less than a week left! 🧠 #ecr
Link to form: buff.ly/8DWT8TV
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We are excited to Introduce the new co-editors in chief Professor David Belin and Professor Tara Spires-Jones!

Looking forward to the next chapter in the brain communications family! 🧠

#neuroscience #braincommunications

We have landed on LinkedIn! 🧠

Click the link to get directed to our profile 👉 buff.ly/J7DgSyv

#neuroscience #braincommunications

Di Gaetano et al. investigate brain network organization in epilepsy-surgery patients. They show that pathological hubs extend beyond the resection area into its neighbourhood, with substantial patient-specific variability 👉 buff.ly/OyU4adZ
#epilepsy

Have you read an outstanding paper published in Brain Communications during 2025? Nominate it for the Early Career Researcher Paper Prize! Nominations open till end of January! 🧠 #ecr
Link to form: buff.ly/8DWT8TV
Find out more at: buff.ly/5WfBuCR

De Las Heras et al. report that associations between measures of cortico-spinal excitability and the performance of an upper-limb visuomotor task are diametrically opposed in patients with cortical and subcortical brain lesions 👉 buff.ly/tBN11RA

Howe et al. report that extended formalin fixation of central nervous system tissues hinders gene expression analysis and that common RNA quality metrics do not reliably indicate archived sample quality 👉 buff.ly/XnKIlYd

Mu et al. report that white matter hyperintensities trigger grey matter atrophy. This degeneration propagates through cortico-subcortical structural networks, mediating declines in executive function and processing speed 👉 buff.ly/cJbwzTI

Akbarian et al. report that texture analysis of MRI detects subtle microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia. Observed even when volumetric differences are absent 👉 buff.ly/MLusTEe
#dementia