Mathieu Decloquement

Finally, an in-depth review #JBC about sialylation in cancer: dual role of sialyltransferases (the “writers”) and siglecs/selectins (the “readers”) in cancer progression. Must-read!
tinyurl.com/yvauu3zj
@mathd34.bsky.social
@siglecdude.bsky.social

#glycotime

Thanks Marcin!

Thanks Brett!

Writers and Readers of Sialylation in Immunoregulation in Cancer Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape cell-cell interactions, and are strongly implicated in regulating immune recognition and tissue homeostasis. In ca...

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem:
🔗 www.jbc.org/article/S002...

Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.

Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...

An amazing week at University of Alberta 🇨🇦with plenty of #glycotime! A big thanks to @glycocode.bsky.social , @giaglyco.bsky.social and to @glyconet.bsky.social for the kind invitation!! Also great to see inspiring glyco-researchers that marked a generation

Great two glyco-days at #GIA2025 🍬

Honored to introduce Prof. Jim Paulson ⭐

Exciting glyco talks, amazing chats ☕, and valuable feedback for the next steps in my project 💡 #glycotime

Wonderful day 2 of #GIA2025 @giaglyco.bsky.social ! We started off with an outstanding talk from @salomepinho.bsky.social followed by a spectacular day of science with talks from @rlhull-meichle.bsky.social, Jason Northey, Alisdair Boraston and Trainees Sogand Makhsous and @mathd34.bsky.social!

Logo of the Glycomics Institute of Alberta, featuring the Glycogang, characters made from the symbolic nomenclature of glycans.

Save the date for #GIA2026 (Nov. 5-6, 2026) which will feature free #glycotime talks by @carolynbertozzi.bskyverified.social , Dr. Mia Huang and more!

Amazing #glycotime immune research on display at GIA2025. Come join us at this free hybrid event and watch talk by some of the best in the field. Register here

Register for virtual or in person attendance for FREE at forms.gle/GGXwhBiRPgA9... #glycotime

Reminder that the deadline to submit an abstract to be considered for a 15 minute talk at GIA2025 is tonight! Don't miss out on presenting your glyco research and the opportunity to have lunch with Dr. Jim Paulson, our trainee-invited speaker! Link to submit: forms.gle/BdDTRsdXmTP9.... #GIA2025

GIA2025 Join us for our fourth annual symposium, a celebration of knowledge and innovation in the field of glycoscience! Whether you’re an aspiring scientist or a seasoned researcher…

We’re excited to invite you to the @giaglyco.bsky.social GIA2025 Symposium on Thursday and Friday, November 6–7. Registration is free and the event will take place in person and virtually for those joining online. glyco-alberta.ca/gia2025/ Come get the latest #Glycogang swag!

🧪 Come join us for free #glycotime Register here for hybrid or in person attendance glyco-alberta.ca/gia2025/

🧬Power your research with GlycoNet Integrated Services’ Molecular Glycobiology node at the ‪@ualberta.bsky.social‬

Offering:
Custom cell & mouse models (CRISPR, transgenics)
Siglec-Fc protein production
Cell engineering & expert support

Explore more services: canadianglycomics.ca/services/

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry Interactions between glycan-binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan i...

🚨 Just published in Mass Spectrometry Reviews! 🚨
Thrilled to share our latest review, summarizing over 20 years of work from the Klassen lab —plus insights from my own PhD research on COIN-nMS, SLOMO-nMS, and charge detection MS.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Schematic representation of the 14 human siglecs, 4 evolutionarily conserved on the left, with low sequence similarity, and 10 on the right sharing a higher sequence similarity to CD33. Siglec-6 is highlighted in yellow as it is the focus of this work. This is Figure 1 in the paper

When glycan recognition is linked to immune response, you need fine tuning! 😎

Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️

doi.org/10.1101/2025...

🔬Meet Dr. @faezehjame.bsky.social‬ , a postdoc at SFU, studying how sugar molecules influence disease. Working in the Vocadlo lab, she is exploring how sugar molecules and the driving enzymes, glycosyltransferases, are involved in health and disease.

Read: canadianglycomics.ca/trainee-at-g...

Good time at the Summer School in Structural Glycosciences organized by @glyco-alps.bsky.social and @anneimb.bsky.social . Was nice to visit the IBS, ESRF and CERMAV and meet a friendly glyco-community in Grenoble 🏔️

Excellent start for the 2025 session of our Structural Glycoscience Summer School with conférences and visit of @esrf.fr beamlines

Big thanks to @irishglycogirl.bsky.social and the whole committee for this amazing event! 👏

Great few days in Maynooth for the 16th Jenner Glycobiology & Medicine Symposium. Grateful to have presented my work from the @siglecdude.bsky.social lab, connect with brilliant glyco-scientists, hear inspiring stories of pioneers, and enjoy Irish music & culture. 🇮🇪🎶🍻 #glycotime

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...

Amazing week at #Glyco27 with top glycoscientists from around the world! 🌎🧪

Grateful for the opportunity to share my research from the @siglecdude.bsky.social Lab 📊🙌

Last day — don’t forget to grab your fav monosaccharide at the @giaglyco.bsky.social booth! 😎

#glycotime @glyconet.bsky.social

We’re kicking off the first full day at Glyco27! Be sure to catch GIA’s Trainee co-chair Mathieu Decloquement’s (mathd34.bsky.social) talk on Tuesday from 5-5:15pm in Hall A during the Cancer session. His talk will be on Deciphering Siglec ligands in cancer to improve immunotherapy. #Glyco27

It’s been great to hear from Dr. Noortje de Haan, Dr. Stacy Malaker, and Dr. Manfred Wuhrer at the Spectrometry / Glycoproteomics Workshop this morning at #Glyco27!

This afternoon’s #Glycobioinformatics Workshop at #Glyco27 is underway!
Led by Dr. Kiyoko Aoki-Kinoshita and Dr. Frederique Lisacek, participants are diving into the latest tools and innovations driving progress in glyco-data analysis. Great turnout and discussion happening now!

Specificity in glycosylation! Have you ever wondered why some glycosyltransferases recognize glycoproteins, some glycolipids, and some both? Together with @kmikolajczyk.bsky.social and @rkaczmarekdr.bsky.social, we try to answer that complicated question.

#glycotime
tinyurl.com/5b6kxhp3

🚨 Don't miss one of the top #glycotime events of the year! The 27th International Glycoconjugate Symposium (Glyco27) and 8th Canadian Glycomics Symposium jointly hosted by the IGO and @glyconet.bsky.social will take place in Edmonton, AB 🇨🇦, from 25-30th of May 2025 🌟🍬 Details at www.glyco27.org/en