Mathieu Decloquement

🧬Power your research with GlycoNet Integrated Services’ Molecular Glycobiology node at the ‪@ualberta.bsky.social‬

Offering:
Custom cell & mouse models (CRISPR, transgenics)
Siglec-Fc protein production
Cell engineering & expert support

Explore more services: canadianglycomics.ca/services/

10.07.2025 18:01 — 👍 4    🔁 4    💬 0    📌 0

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry Interactions between glycan-binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan i...

🚨 Just published in Mass Spectrometry Reviews! 🚨
Thrilled to share our latest review, summarizing over 20 years of work from the Klassen lab —plus insights from my own PhD research on COIN-nMS, SLOMO-nMS, and charge detection MS.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

30.06.2025 16:57 — 👍 9    🔁 3    💬 1    📌 0

Schematic representation of the 14 human siglecs, 4 evolutionarily conserved on the left, with low sequence similarity, and 10 on the right sharing a higher sequence similarity to CD33. Siglec-6 is highlighted in yellow as it is the focus of this work. This is Figure 1 in the paper

When glycan recognition is linked to immune response, you need fine tuning! 😎

Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️

doi.org/10.1101/2025...

22.06.2025 10:42 — 👍 51    🔁 23    💬 2    📌 4

🔬Meet Dr. @faezehjame.bsky.social‬ , a postdoc at SFU, studying how sugar molecules influence disease. Working in the Vocadlo lab, she is exploring how sugar molecules and the driving enzymes, glycosyltransferases, are involved in health and disease.

Read: canadianglycomics.ca/trainee-at-g...

19.06.2025 16:07 — 👍 6    🔁 2    💬 0    📌 0

Good time at the Summer School in Structural Glycosciences organized by @glyco-alps.bsky.social and @anneimb.bsky.social . Was nice to visit the IBS, ESRF and CERMAV and meet a friendly glyco-community in Grenoble 🏔️

19.06.2025 16:37 — 👍 10    🔁 1    💬 0    📌 0

Excellent start for the 2025 session of our Structural Glycoscience Summer School with conférences and visit of @esrf.fr beamlines

16.06.2025 15:10 — 👍 9    🔁 3    💬 0    📌 0

Big thanks to @irishglycogirl.bsky.social and the whole committee for this amazing event! 👏

15.06.2025 21:58 — 👍 5    🔁 0    💬 0    📌 0

Great few days in Maynooth for the 16th Jenner Glycobiology & Medicine Symposium. Grateful to have presented my work from the @siglecdude.bsky.social lab, connect with brilliant glyco-scientists, hear inspiring stories of pioneers, and enjoy Irish music & culture. 🇮🇪🎶🍻 #glycotime

15.06.2025 21:58 — 👍 7    🔁 0    💬 1    📌 0

An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...

Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...

14.06.2025 21:05 — 👍 7    🔁 3    💬 2    📌 1

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...

12.06.2025 13:26 — 👍 12    🔁 4    💬 1    📌 0

Amazing week at #Glyco27 with top glycoscientists from around the world! 🌎🧪

Grateful for the opportunity to share my research from the @siglecdude.bsky.social Lab 📊🙌

Last day — don’t forget to grab your fav monosaccharide at the @giaglyco.bsky.social booth! 😎

#glycotime @glyconet.bsky.social

30.05.2025 15:08 — 👍 5    🔁 1    💬 0    📌 0

We’re kicking off the first full day at Glyco27! Be sure to catch GIA’s Trainee co-chair Mathieu Decloquement’s (mathd34.bsky.social) talk on Tuesday from 5-5:15pm in Hall A during the Cancer session. His talk will be on Deciphering Siglec ligands in cancer to improve immunotherapy. #Glyco27

26.05.2025 15:50 — 👍 5    🔁 2    💬 0    📌 0

It’s been great to hear from Dr. Noortje de Haan, Dr. Stacy Malaker, and Dr. Manfred Wuhrer at the Spectrometry / Glycoproteomics Workshop this morning at #Glyco27!

25.05.2025 19:49 — 👍 6    🔁 2    💬 0    📌 0

This afternoon’s #Glycobioinformatics Workshop at #Glyco27 is underway!
Led by Dr. Kiyoko Aoki-Kinoshita and Dr. Frederique Lisacek, participants are diving into the latest tools and innovations driving progress in glyco-data analysis. Great turnout and discussion happening now!

25.05.2025 22:00 — 👍 7    🔁 3    💬 0    📌 0

Specificity in glycosylation! Have you ever wondered why some glycosyltransferases recognize glycoproteins, some glycolipids, and some both? Together with @kmikolajczyk.bsky.social and @rkaczmarekdr.bsky.social, we try to answer that complicated question.

#glycotime
tinyurl.com/5b6kxhp3

07.05.2025 09:13 — 👍 25    🔁 14    💬 0    📌 0

🚨 Don't miss one of the top #glycotime events of the year! The 27th International Glycoconjugate Symposium (Glyco27) and 8th Canadian Glycomics Symposium jointly hosted by the IGO and @glyconet.bsky.social will take place in Edmonton, AB 🇨🇦, from 25-30th of May 2025 🌟🍬 Details at www.glyco27.org/en

07.04.2025 09:19 — 👍 8    🔁 8    💬 0    📌 0

Job Opening – A Postdoctoral fellow or Research Associate – Macauley Lab

We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...

04.02.2025 15:00 — 👍 10    🔁 10    💬 0    📌 0