Irene Serrano

The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells - Nature Communications O-GlcNAcylation can regulate protein properties and functions. Here, the authors systematically study its impacts on protein solubility and biocondensate formation. O-GlcNAc dramatically reduces prote...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells #NatCommun #MassSpec www.nature.com/articles/s41...

Associate or Senior Editor (Organic Chemistry), Nature Communications Job Title: Associate or Senior Editor (Organic Chemistry), Nature Communications Organisation: Nature Portfolio Locations: Jersey City, London, New York, Philadelphia or Washington DC - hybrid working...

Nature Communications is looking to hire an organic chemist – more details in the link below #Chemsky #Chemjobs 🧪

Structural basis for the ubiquitin chain recognition of the human 26S proteasome Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann
Let me walk you through it 🧵 1/9

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics - Nature Methods Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single HeLa cells.

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies!
www.nature.com/articles/s41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

ATG8ylation of vacuolar membrane protects plants against cell wall damage - Nature Plants ATG8ylation of the tonoplast, triggered by cell wall damage, acts as a vital vacuolar quality control mechanism that safeguards vacuolar integrity and ensures cell survival under stress.

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage.
Check it out here: www.nature.com/articles/s41...

Hold this date for the 2nd UK Proteostasis Network in Dundee👉🏾 3-5 June 2025. This will be a joint meeting with the UK Autophagy network. More info coming soon proteostasisuk.co.uk/conference-2...
@ukproteostasis.bsky.social

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR
& NV
shorturl.at/fImjA

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control - Nature Communications LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle c...

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control #NatCommun www.nature.com/articles/s41...

A majority of eukaryotic proteins are N-terminally acetylated. Here is an updated review of the responsible enzymes and the impact of this modification for proteins, cells and organisms @naturecomms.bsky.social @ispt-proteinterm.bsky.social #acetylation #N-termini #N-degron rdcu.be/d6mbd

Tell me they are growing up with cats without telling me that they are growing up with cats…

Image credit: Togna Zambogna

Our call for papers with @naturecomms.bsky.social, Communications Chemistry & Scientific Reports welcomes manuscripts exploring glycans in the broadest sense, seeking basic, translational, and applied glycobiology research:
www.nature.com/collections/... 🧪

MPicker: visualizing and picking membrane proteins for cryo-electron tomography - Nature Communications Visualization and picking of membrane proteins in cryoET tomogram is often challenging. Here, the authors developed a software MPicker based on membrane flattening to simplify the visualization, picki...

Paper of interest for the #CryoET folks.

www.nature.com/articles/s41...

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination

www.nature.com/articles/s41...