Lüders Lab

View of Barcelona from Collserola

The “three chimneys” view from Collserola

View of Sagrada Família and other tall buildings in Barcelona from Collserola

View from afternoon #bike ride - Which one is the tallest? 🧐
#building #Barcelona

The mother of all meetings is here:
meetings.embo.org/event/26-cen...

Pictures of a cow (Bos taurus), Veronika, who uses a deck brush to self-scratch.

Flexible tool use by a cow. Best video I have seen in a while, including the closing statement by the farmer.
Veronika for #President!

https://www.cell.com/current-biology/fulltext/S0960-9822(25)01597-0

The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now!

Deadline: 1 June

https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

We must have been #ExtraNice this year- our #cilia & #centrosome 🧪 community- 🎅 Santa just dropped the 1st session of 2026 line-up @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposia- www.eventbrite.co.uk/e/bscb-genso... See you on the other side! Happy Holidays!

There are other things like making the last 5 years of all social media activity accessible through setting profiles public and providing handles. Including WhatsApp - would kill many ESTA applications - and including this thread 😬

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.

Marcos Fariña thesis defense presentation

Marcos Fariña thesis defense with Flowers and tribunal members

Congratulations Dr. Fariña-Mosquera!!! A new doctor in the @luderslab.bsky.social!!! Big thanks to tribunal members Isabelle Vernos, Virginie Hamel @centriolelab.bsky.social , and Fernando Romero-Balestra!

The dual role of the centrosome in organizing the microtubule network in interphase | EMBO reports image image During interphase, microtubules can be generated from a variety of microtubule‐organizing centers (MTOCs) the activity of which is regulated in a hierarchical manner. The centrosome (CTR)...

You mean when only centromes are lost? Yes, because of the Golgi MTOC. The Rios lab paper actually showed it first, check Fig 7 - centrinone + AKAP450 KO destroys both centrosome and Golgi MTOC, and MTs become disorganized, clearly different from WT. www.embopress.org/doi/full/10....

Self-assembly of pericentriolar material in interphase cells lacking centrioles In the absence of centrioles, components of pericentriolar material can self-organize into a single compact microtubule-organizing center through dynein-mediated transport of pericentrin-containing pr...

This nice paper by Anna Akhmanova’s group does not address anchoring specifically, but organizing function. The problem is that if you remove centrioles, PCM still clusters or the Golgi takes over. If you prevent that (centrinone + AKAP450 KO) MT are completely disorganized. doi.org/10.7554/eLif...

Not saying motors, plus end regulators, MAPs don’t contribute. I believe some microtubules are anchored, but others are perhaps released - shown for the centrosome. Could be pulling by motors or loss of anchoring/nucleation without anchoring. Quite a knowledge gap here, I would say.

It does not only nucleate, it also anchors minus ends. This determines microtubule orientation (all minus ends at MTOC, all plus ends away from it). Because of this, modulating the shape and distribution of the MTOCs, also controls the overall shape of the network.

Doesn’t nucleation + anchoring of minus ends control microtubule orientation and, through shape and distribution of the MTOC, overall microtubule network shape and polarity? I agree it isn’t always the “center”, but I still think it has organizing activity.

What about their function in anchoring minus ends?

Congrats @araujolabub.bsky.social, make the flies breathe!

I see 6 fold symmetry and 9 fold asymmetry

Happy Halloween everyone! 🎃

Congratulations to the @estebanezlab.bsky.social lab and collaborators!!! A great story on the surprising repertoire of nuclear receptor oligomeric configurations and their regulatory roles.

Harder to focus on the science if it is poorly presented, I’d say.

Salt marshes ‘ Las Salinas’, Cabo de Gata Natural Park, Spain

Why would anyone want to be a scientist? It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz

💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚

ERC to introduce seven-year €7 million ‘super grants’ in 2026 The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...

See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪

"Super level" funding programs IMO are a huge waste of money - they benefit big labs at the cost of defunding others. We had big "Foundation grants" in Canada (albeit at a much smaller scale than similar programs in the USA/EU)... TL;DR it nearly ruined the sustainability of our research ecosystem

…as wobbly tentacles that capture you?

The #ESEB2025 meeting in Barcelona is getting closer, there are still places available but time for registration is running up. Are you going to miss the main evolutionary biology event in Europe this year?
👇
eseb2025.com/registration/

Woah! Sick reconstitution work showing that MAP6d1 recruits tubulin to form B tubules on A tubule templates, and ALSO intra-luminal protofilaments, which apparently are present in neuronal microtubules.
So not only actin inside microtubules, but also additional tubulin protofilaments?!? Wild!

Centriole biogenesis is seeded by CEP152-CEP63-PCNT aggregates propagating outside the centriole through the Alström syndrome protein ALMS1 While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...

Check out this new 🔥work from Bryan Tsou’s lab - where does the information on how to assemble #centrioles with specific symmetry come from? Forget what you thought you knew about #centriole #biogenesis!!!

www.biorxiv.org/content/10.1...

It is alive!!!
Prompt to Google’s Vids AI video generation tool: “Show #microtubule #nucleation from gamma-tubulin ring complexes with microtubules displaying dynamic instability.”