Marius Lemberg

Hi everyone!
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins

New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

YouTube video by Bodo Wartke Das endoplasmatische Retikulum

Just stumbled upon a German tongue-twister song by Bodo Wartke… about the sexiest cell organelle. Yes, endoplasmic reticulum - your moment has come.
youtube.com/shorts/EP5pd...

N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...

CECAD receives renewed DFG funding! 🎉 We continue to unlock the biology of aging 🧬 and advance healthy aging for all! 👵👴

➡️ uni.koeln/GAPGK

#CECAD #AgingResearch #ExcellenceCluster #DFG #HealthyAging @unicologne.bsky.social

📡 Broadcasting a new signal
On the eve of #WorldPressFreedomDay, R.E.M. is proud to announce Radio Free Europe 2025—a five-track benefit EP saluting 75 years of RFE/RL’s fearless journalism. Watch the full Dispatch video + learn more about Jacknife Lee and Mitch Easter RFE remixes
ffm.to/remrfe2025

🔬 Hiring: Postdoctoral Fellow

Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.

🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training

This is a very sad day. Shock, despair, disappointment, disbelief... These only scratch the surface in describing this decision and how I feel. I began my career in Parkinson's research in Richard's lab. What happens now to all the trainees still there?

As women in academia, having children can feel impossible. Talking about it makes us feel less alone The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write

And another poignant reminder that scientists are human too
www.science.org/content/arti...

🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast!

Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science www.science.org/doi/10.1126/...

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

Congrats!

That was an inspiring meeting! Huge tanks to @aforrester.bsky.social and Emma @fenech-lab.bsky.social for hosting this incredible event!

Susanne Steigleder (University of Cologne) showed exciting data on the role of the intramembrane protease RHBDL4 in regulating protein trafficking. #ERRedox2025

Structure of human PINK1 at a mitochondrial TOM-VDAC array Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...

Structure of human PINK1 at a mitochondrial TOM-VDAC array | Science www.science.org/doi/10.1126/...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Wow! The Proteasome generates antimicrobial peptides that directly affect bacterial membranes #proteostasis
www.nature.com/articles/s41...

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

Incredible work led by Dr. Satarupa Bhaduri, co-authors
@mackevinbraza.bsky.social and others. This work wouldn't have been possible without our collaborators
Dr. Anthony O'Donoghue, @rommieamaro.bsky.social @marius-lemberg.bsky.social and Dr. Kvido Strisovsky

Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life.
Check out the Programm and register until Feb 28!
redox-gbm-meeting-2025.uni-koeln.de
#redox #redoxbiology #gbm
@gbmev.bsky.social

Had a great time in Cologne talking science with @trentini-lab.bsky.social @ulrichlab.bsky.social @riemerlab.bsky.social @marius-lemberg.bsky.social and many more! Thank you for the warm welcome! And for the invitation @valentinapiano.bsky.social

A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.

Auschwitz was at the end of a long process. It did not start from gas chambers.

This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.

Auschwitz took time.

Article on the mass eXit of German universities from plattform X in protest against anti-democratic discourse pushed by Elon Musks algorithms.

This is a turning point.

We Europeans have the power to push X into irrelevance across our continent. Freeze or delete your accounts now.

Media, it’s time to stop citing X.

Dozens of universities are leading the way. Let’s limit Elon Musk’s influence in 🇪🇺.

#eXit #SciXit #Democracy

Universität zu Köln Hauptgebäude, Blauer Himmel, Mond

👋Hallo Bluesky wir sind #uniköln // we are #unicologne

I am always trying to upgrade the starter pack of Chaperonologists / PQC / Proteostasis scientists

If you want to be added, feel free to ask.

go.bsky.app/Co7Tuub

Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

Nikita Sergejevs, Pedro Carvalho and colleagues find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Gunter Demnig bei der Verlegung der Gedenktafel vor der Antoniterkirche, 1995/1996 Dokumentationszentrum, Kunst, Köln

Am 16. Dezember 1992 verlegte der Künstler Gunter Demnig den ersten Stolperstein in Köln mit dem er vor der letzten bekannten Adresse des Opfers des Nazi Unrechtsregimes ein Zeichen setzen wollte, daß diese Menschen nicht vergessen sind und nicht vergessen werden dürfen.

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence Entry and exit from quiescence require changes in cellular nutrient acquisition. How quiescent cells reduce nutrient uptake was unclear. Here, we demonstrate that cells entering quiescence select plas...

How do quiescent cells stop to eat? TXNIP mediates LAT1/SLC7A5 endocytosis to curb amino acid uptake and to meet low metabolic needs of cells entering quiescence. Defects can result in metabolic disease. biorxiv.org/content/10.1... by @Jenny12119
with @Hesso_F_Sci
@ThedieckLab

🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking.

Check out the program and register here 👇

events.faseb.org/event/endoplasmic-reticulum-function-disease