Corbet's couloir next? Stefan's chute? too soon?

Just in time for my grad school lecture on NER!

Great conference!!

RNAseH2 is super picky...which is not always a good thing?

Yup...basic research PI, greatest job ever. Most of the time.

100% agree. would definitely recommend.

Very cool!

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals https://www.biorxiv.org/content/10.64898/2025.12.22.695953v1

Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj

Or does NHEJ repair one strand, leaving the opposite strand for a single strand break repair pathway?

Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?

Great piece of work - congratulations, all!

Very cool! Figs 2 and 3 are especially cool!

So cool. And hey, its a good thing NHEJ doesnt slow down when you get sleepy.

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes - Nature Communications DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

Base excision repair in chromatin: A tug-of-war for DNA damage Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…

🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs!
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....

Great scientist. "One of the most influential" - definitely.

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Pol delta's exo at it again!

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!

www.nature.com/articles/s41...

SoCal Genome Stability Symposium The annual Genome Stability Symposium provides a forum for trainees in the Southern California region to present their research on the field of genome stability.

Registration is open for the 2025 SoCal Genome Stability Symposium. Free registration. All talks by trainees. www.cityofhope.org/genome-stabi...

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

Also available in the Ramsden lab....Lab manager (gap year, temp employee) OR research tech/lab manager (longer term, SHRA).

Also: Research positions in the Ramsden lab. Post doctoral position - 5 years funding available. Cross-country collaborative, working closely with the groups of Gupta, Rothenberg, Wood, and Doublie.
Some example pubs from the last two post docs: PMIDs 37968395,35927262, 2963245, 30213916, 26240371

Good news for Adam, Kishore, and the Ramsden lab - their paper describing how each strand of a DSB is repaired has been accepted for pub in principle for Nature Communications. More to come on this soon...