Meng Wang

Our lab road trip to #EMGS2025 at Rochester NY. Thank you to @emgsus.bsky.social for travel awards and poster presentations by postdoc Chris Mellor, grads Brandon James and Nick Cheng. A friendly and inviting community to bring trainees!

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Cornell NCAA 2025 D1 Champions! 13-10 Win over Maryland. What a game! @cornelluniversity.bsky.social @ncaa.bsky.social

Many congratulations to Saeideh Azad, our talented Cornell undergraduate student who is graduating today @cornelluniversity.bsky.social. Saeideh has done a tremendous job working in our lab! We wish her all the best in her future endeavours!

Many congratulations Stephanie! Looking forward to the discoveries from the Xie lab!

Ok #AACR25, I’m truly impressed. A live sign-language interpreter translating Inigo’s @imartincorena.bsky.social plenary talk on somatic tissue mutational landscape. I want to learn the sign for ‘clonal’.

Exciting talk #AACR2025 @theaacr.bsky.social from my colleague and friend Dr. Karuna Ganesh! insights into why colon cancer is rising in young. A cool DNA damage mechanism! @karunamdphd.bsky.social @mskcancercenter.bsky.social

Many congratulations to our newest PhD student Emma Kosmeder @cornelluniversity.bsky.social for achieving an Honorable Mention in this year’s #NationalScienceFoundation GRFP! Considering only 1000 GRFP awarded this yr versus >2000 awards in past yrs, I am so proud to be mentoring Emma in her PhD.

Absolute delight and privilege to host Dr. Anna Beaudin @beaudinlab.bsky.social from @utah.edu. Very exciting work on fetal folate🥑metabolism rewiring 🩸blood stem cells. Thank you for visiting Cornell and passing your wisdom to our trainees and assistant profs!

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

Congratulations Rosado lab! Great to see this work out in print!

Many congratulations!

Mechanisms of maternal antibody interference to rotavirus vaccination Maternal antibodies (MatAbs) are transferred transplacentally during pregnancy and through breast milk after birth to provide protection whilst the neonatal immune response is immature. However, MatAb...

The maternal antibody paradox: how are these antibodies both good and bad? Excited to share our new insights for rotavirus vaccines
www.biorxiv.org/content/10.1...

During this chaotic time, I take satisfaction doing little things that improve the lab. Today I rigged an argon gas blower for our chemical hood. #labrat

NIH indirects case update:

Hearing ongoing now, and I'll try to live tweet some notable exchanges.

Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:

(I'm paraphrasing here)

Many congratulations Will! Beautiful work!

It’s day 1 of the cut to NIH indirects and universities are scrambling to adapt. I’m going to post a series of videos on all the things I take for granted, but are both vital to research and covered by indirects for research grants.

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates Notice Number: NOT-OD-25-068 Key Dates Release Date: February 7, 2025 Related Announcements None Issued by Office of The Director, National Institutes of Health (OD) Purpose

🚨RED ALERT for 🧪:

The Trump NIH just gashed indirect costs. This is a direct attack on universities.

“Pursuant to this Supplemental Guidance, there will be a standard rate of 15% across all NIH grants for indirect costs.” 😮

Just a devastating Friday night news dump. #scicomm #academicaky

Yes, doubleplusgood. Me writing my untruth grant in 2025.

Merry Christmas and Happy New Year from the Wang Lab! I’m so thankful to my lab, discussing and doing science with you guys is the best part of the job!

Many congratulations Ana and team!

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...

Many congratulations to @rockefelleruniv.bsky.social MDPhD student and soon-to-be Dr Nicky Blobel from Smogorzewska Lab for passing his PhD defense today! It was my pleasure to be your external examiner and share our passion on endogenous DNA 🧬damage!

Can someone please rank my emotional stability compared to all undergraduates in their institution? I think my lab deserves to know.

Many congratulations Dr. Cheng! @chloecheng.bsky.social Well deserved! Wishing you all the best on your next adventure!

MRC LMB

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Join us on this journey as we advance science and improve human health together!
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