Alex Matia

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff - Nature Microbiology During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce hos...

🚨 Out now!

Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff

#MicroSky 🦠

#NorthwesternUniversity #FeinbergSchoolofMedicine

www.nature.com/articles/s41...

Vietnam reports H5N1 avian flu case with encephalitis

Tests on respiratory samples were negative, but results were positive for the cerebrospinal fluid sample.

www.cidrap.umn.edu/a...

Out now at @nature.com

The entry receptor for enterovirus D68 👀

www.nature.com/articles/s41...

Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese

Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese.
#H5N1
www.cidrap.umn.edu/avian-influe...

A white and gray background with blue circles. A family of four sits together. "Protect the youngest among us! Stay up to date on your measles vaccine."

📣Measles is an extremely contagious virus. Make sure you and your family are up to date on your measles vaccine to stay protected.

📲 Find more vaccination information at: cdph.ca.gov/Programs/CID/DCDC/Pages/Immunization/family.aspx.

#Measles #Vaccinate #StayHealthy #HealthyCA4All

We're hiring! Join the Blythe lab as a full-time junior researcher starting Summer 2025. Explore GPCR trafficking and signaling using biochemistry, cell biology, and proteomics. Mentorship, hands-on experience, and career growth await! Apply now: hr.myu.umn.edu/jobs/ext/367... (UMN job ID #367053)

Bird flu found in Arizona milk suggests another spillover from birds to cows Another spillover of the H5N1 bird flu virus from wild birds to dairy cattle appears to have occurred, this time in Arizona.

Because there's not enough going on: Arizona has found #H5N1 #birdflu in milk and it looks like yet another spillover from wild birds.
www.statnews.com/2025/02/14/a...

Graph showing that prior to 1963 when the measles vaccine was introduced, there were around 300,000-700,000 measles cases per year. Within a few years of the vaccine, the number of cases fell below 20,000/year. There were a blips where cases rose, but shortly after the second vaccine dose was recommended in 1989, annual cases have generally been well below 1,000 cases. In 2000, measles elimination was declared in the US. Now we have sporadic outbreaks that typically spread among unvaccinated people. Chart is from Center for American Progress and is based on CDC data on measles cases.

Vaccines work! As measles cases have recently been reported in Alaska, Georgia, New York, Rhode Island and Texas, it's important to remember that prior to the introduction of the measles vaccine in 1963, measles killed 400-500 people and resulted in ~48,000 hospitalizations per year.

🚨 🌟 Submissions & Registrations Open for #ViBioM2025! 🌟 🚨
Join us 13–15 May 2025 in Lisbon, Portugal! 🦠💻 Present your research, connect with global experts, and shape the future of #Virology & #Bioinformatics.

📅 Details & links: evbc.uni-jena.de/events/vibio...

Identification and characterization of novel bat coronaviruses in Spain The zoonotic transmission of bat coronaviruses poses a threat to human health. However, the diversity of bat-borne coronaviruses remains poorly characterized in many geographical areas. Here, we recov...

A coronavirus that is able to bind the human ACE2 receptor has been found in Spain! @csic.es

www.biorxiv.org/content/10.1...

A great reminder that not only respiratory viral infections rise during the winter season, but other pathogens like #Norovirus also come in yearly waves.

A man in a white T-shirt is pictured clutching his stomach while lying in bed. Headline reads: "Norovirus Outbreaks Surge Nationwide, CDC Says." Photo credit: Getty Images.

There have been an unusually high number of norovirus outbreaks in the U.S. this month, according to the CDC.

Here’s what to know about symptoms, treatment, and reducing your risk of infection. nyti.ms/4gyr6JO

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada...

From conjunctivitis to critical illness in 96 hours after infection with #H5N1 influenza (the bird strain D1.1). Three antivirals plus plasma exchange treatment were necessary 👀.

www.nejm.org/doi/full/10....

Flu season is here. Watch out and take care.
...and let's hope no reassortments with #H5N1 occur.

www.cdc.gov/fluview/surv...

Gov. Newsom declares emergency in California after CDC confirms severe case of bird flu in Louisiana As the CDC confirmed a severe case in Louisiana of a patient hospitalized with H5N1 bird flu, Gov. Gavin Newsom declared a state of emergency in California related to the virus.

Gov. Newsom declares emergency in California after CDC confirms severe case of bird flu in Louisiana
www.latimes.com/environment/...

#HPAI #H5N1

Huttenhain Lab | Home The Huttenhain Lab at Stanford University studies cellular signaling networks to uncover how cells decode extracellular cues into dynamic physiologic responses.

Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: www.huttenhainlab.com

By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/...

#TeamMassSpec

⚠️ BREAKING:

California state health officials confirmed that H5N1 bird flu virus has been detected in sold raw milk from the Fresno-based Raw Farm dairy.

Santa Clara County public health officials collected the sample.

🙋‍♂️

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics https://www.biorxiv.org/content/10.1101/2024.01.13.575413v1 Poxviruses are a large group of DNA viruses with exclusively cytoplasmic life cycles and complex gen

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics https://www.biorxiv.org/content/10.1101/2024.01.13.575413v1

Check out our new preprint, describing the transcriptional and proteomic events during Vaccinia virus infection in human cells.
Spearheaded by the incomparable @alexmatia.bsky.social, who spent a few super productive months with Carolina Arias and me at the Biohub.
#LoveVirology #PoxRocks

Check out our preprint for the entire story:

www.biorxiv.org/content/10.1...

Many thanks to @marcoyannic.bsky.social, Carolina Arias, and many colleagues at the #CZBiohub

And we fractionated the proteomes of infected cells to map the subcellular localizations of viral proteins, and the relocalization of host proteins upon infection.

We infected cells with Vaccinia virus and used single-cell transcriptomics to understand how infection progresses at single-cell resolution.

📣NEW PREPRINT ALERT!

Thrilled to share our latest research delving deep into Vaccinia virus infection dynamics using scRNAseq and fractionation proteomics:

-Antiviral response dynamics
-Host and virus proteomic maps
-Proteome relocation

#lovevirology #poxrocks 🧵👇