Moustafa Algamal

Excited to be attending AAIC 2025 at the Toronto Convention Centre! I’ll be presenting my poster (#188) tomorrow — please stop by and take a look.

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...

Exciting to see growing work on microglial GABA receptors and their role in regulating inhibition. Here, hyperactive inhibitory neurons in epilepsy activate microglia via GABA. Activated microglia then eliminate inhibitory synapses through a GABA–C3 feedback loop. www.nature.com/articles/s41...

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution - Communications Biology Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...