Amar Sahay

Good morning from a recent memory.

Happy Diwali to all those who observe it. Diwali signifies the victory of light over darkness, good over evil, and knowledge over ignorance. We will all benefit.

Damn! Cant beat these fall morning runs! With ⁦‪@singhcredible‬.bsky.social
Thx for chatting about trials and tribulations of ultras, fueling, and running for life.

Cognitive Resilience in Aging Degus is Linked to CA3 Hippocampal GABAergic Integrity https://www.biorxiv.org/content/10.1101/2025.10.18.682786v1

“The threat of AGI cannot be overstated”
~Dachshund Community notes, Regional Chapter.

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors Márquez-Valadez and colleagues show that neuropsychiatric disorders alter the generation of new neurons in the adult human brain. Major depression, schizophrenia, and bipolar disorder disrupt early st...

Variability in numbers of new neurons in the adult hippocampus: Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors: Cell Stem Cell

The concomitant warmth of fire and human-gaze triggered oxytocin is thought to have transformed the beastly wolf into domesticated hound.

Transitions. Imminence. Fleeting hues.

GM NYC.

Photo: Cecilia Odlind

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

Cider donut (mini) while taking in foliage in southern VT after college reunion-Check. #Fallnevergetsold

Happy Birthday Mahatma Gandhi. May we all take a moment to learn from you today.

Great news Josh!

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects Walsh et al. establish a human forebrain assembloid protocol that supports the derivation of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in disease-associated structura...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects www.cell.com/neuron/fullt...

According to Maine state law, workers are not entitled to overtime pay for the following activities: “The canning, processing, preserving, freezing, drying, marketing, storing, packing for shipment or distribution of: (1) Agricultural produce; (2) Meat and fish products; and (3) Perishable foods.”

Exclusive: Biogen calls it quits on AAV gene therapy, again Biogen is ending its gene therapy work that relies on adeno-associated viruses, or AAVs, the company confirmed to Endpoints News, making it the latest pharma to walk away from the viral-based delivery...

GT is a tough space and I think despite advances with capsid engineering, systemic delivery for CNS is a hard challenge. Direct brain/CSF is a better bet for many reasons.

AMT-130 consists of an AAV5 vector carrying an artificial micro-RNA specifically tailored to silence the huntingtin gene.

Levels of neurofilaments in spinal fluid should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Bravo: GT for Huntington's disease a success: 3 years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life.

www.bbc.com/news/article...

Rest in peace my friend. Your contributions to humanity and your humanity will always be cherished. We will pay it forward.

Years of hits to the head prime the brain for decline Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein.

Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein

go.nature.com/4n8UwRQ

CRISPR activation for SCN2A-related neurodevelopmental disorders Nature - Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in...

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss.

rdcu.be/eGU0W

Olympus Divers in Morehead city

The wreck is @120 feet, sharks @ 60 feet, and barracudas are at @30 feet. Probably the best place in the world to dive with Sand Tigers.

Aug 9, 2023 Diving with sand tigers at the U-352, German U-boat, wreck off the North Carolina coast.

Battle scars like a great white’s. ❤️ distance running and shark diving!

Learned a lot about myself and training to push the “limit”. Need to work more on fueling (carb intake). Running community is uplifting, in the pain cave together until the end when we revel in the journey completed. W/ @singhcredible.bsky.social
and Victor, friends on this journey.

Hardest race of my life. Finished strong with other inspiring runners. 8.5 hours of 🏃🏽‍♀️ 70-82F /94% H/2500 ft elevation. 25 x 100 mg salt intake to reverse two bouts of leg cramps. So much time alone in these beautiful woods avoiding rabbit holes of weakness..

Never thought Id lose a Saturday to an UltraM.The entry/exit from woods in Ultras is such a primal attraction even if the last stretch is a pain cave. So much was mental (not giving up) and calmly managing challenge (salt, cramps, roots/rocks) 50K Carlisle Fall Classic Done! 1/n

Cool!