David Konrad

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Love the concept!!

Same 😊

Big thanks to our co-authors from academia: @fragrisoni.bsky.social, @dirktrauner.bsky.social, Marcel Bermudez and from industry: Marcel Mülbaier and Clemens Dialer (Grünenthal GmbH).

Here, we discuss the potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses.

It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....

But that is not all! To showcase the potential of dfdc azobenzenes for the development of chemical tools, we synthesized dfdc-OptoBI-1 and demonstrated its biological activity as a red light-operated activator of TRPC6 channels in HEK293 cells.

The data was used to establish a computational approach that allows to compute realistic UV-vis spectra by combining TD-DFT excited-state calculations with MD simulations. As such, our combined experimental and computational study enables the in silico design of new highly red-shifted photoswitches.

In total, we have added 15 new visible light-operated photoswitches to the toolbox for the development of optical devices with relaxation rates across multiple orders of magnitudes and identified several examples with stronger bathochromic shifts than the dfdc azobenzene lead structure.

We have developed synthetic protocols for a variety of derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold and performed an in-depth study into their photophysical properties using NMR, UV-vis and X-ray analysis.

I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩

We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!

We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.

📢 Only one more week to apply!

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

Startseite Wir verwenden Google für unsere Suche. Mit Klick auf „Suche aktivieren“ aktivieren Sie das Suchfeld und akzeptieren die Nutzungsbedingungen.

We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out!
👇
www.mls.ls.tum.de/tnm

So cool! 🤩

DNA Mimic Foldamer Recognition of a Chromosomal Protein Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

DOGE By The Numbers
theonion.com/doge-by...

A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs)

Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!

www.nature.com/articles/s41...

Thanks Ivana!

Thanks Johannes!

Managing to score a professorship without a Cell, Science or Nature paper.

When grant writing is become so intense that you need to procrastinate a little by posting on #ChemSky.

YouTube video by Memex Gandalf was delayed...😂

PI had an important conference to attend...

Voting for our new government in 🇩🇪✔️

Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know
go.bsky.app/EwimNbK

The "Fluorescent Probes, Sensors and Fluorophores" starter pack got substantial additions worth a new look.

Please raise you hand 👋 in the replies if you want to be added too.

go.bsky.app/MtgJE4w

🤘