Pascal Grumbach

Rewriting the Grand Plan of Clinical Neuroscience A Review of “Elusive Cures” by Nicole C. Rust

Rewriting the Grand Plan of Clinical Neuroscience

A Review of “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That” by Nicole C. Rust ( @nicolecrust.bsky.social )

www.psychiatrymargins.com/p/rewriting-...

Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes - Nature Communications Consistent local activity reductions in autism co-localize with glutamatergic and GABAergic neurotransmission. These patterns resemble brain changes induced by ketamine, highlighting altered excitatio...

doi.org/10.1038/s414...

This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social

4) Specifically, ketamine reduced functional activity in those regions of the default mode network where it was also reduced in autism.

3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.

2) The consistent functional alterations in autism co-localized with distinct neurotransmitter properties, including glutamatergic (NMDA, mGluR5) and GABAergic (GABAa) neurotransmission.

1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

Postdoktorandin / Postdoktorand / PostDoc – Klinik für Psychiatrie, Psychosomatik und Psychotherapie Postdoktorandin / Postdoktorand / PostDoc – Klinik für Psychiatrie, Psychosomatik und Psychotherapie

Looking for a 3-year 100% postdoc position at the intersection of mental health, neuroimaging and biological markers? Come join our team: short.sg/j/59191808

Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

JuSpace 2.0 is now released. Key changes:
- New modern UI (also standalone is now available upon request)
- New visualization functionalities
- Added many new PET maps
- Added different cell atlases
github.com/juryxy/JuSpace