Rewriting the Grand Plan of Clinical Neuroscience
A Review of “Elusive Cures” by Nicole C. Rust
Rewriting the Grand Plan of Clinical Neuroscience
A Review of “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That” by Nicole C. Rust ( @nicolecrust.bsky.social )
www.psychiatrymargins.com/p/rewriting-...
20.09.2025 12:58 — 👍 38 🔁 10 💬 0 📌 5
This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social
17.09.2025 12:27 — 👍 3 🔁 0 💬 1 📌 0
4) Specifically, ketamine reduced functional activity in those regions of the default mode network where it was also reduced in autism.
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3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.
17.09.2025 12:27 — 👍 0 🔁 0 💬 1 📌 0
2) The consistent functional alterations in autism co-localized with distinct neurotransmitter properties, including glutamatergic (NMDA, mGluR5) and GABAergic (GABAa) neurotransmission.
17.09.2025 12:27 — 👍 1 🔁 0 💬 1 📌 0
1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.
17.09.2025 12:27 — 👍 0 🔁 0 💬 1 📌 0
Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.
17.09.2025 12:27 — 👍 9 🔁 3 💬 1 📌 0
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
04.08.2025 14:26 — 👍 72 🔁 42 💬 1 📌 0
JuSpace 2.0 is now released. Key changes:
- New modern UI (also standalone is now available upon request)
- New visualization functionalities
- Added many new PET maps
- Added different cell atlases
github.com/juryxy/JuSpace
10.04.2025 09:47 — 👍 0 🔁 1 💬 0 📌 0
The Translational Neuroimaging Marburg Lab (TNM-Lab) links experimental psychology, neuroimaging and the clinical neurosciences. https://tnm-lab.com/ @straubeb.bsky.social
Laboratory for Affective & Translational Neuroscience, University of Maryland | shackmanlab.org | affective neuroscience | "pessimism of the intellect, optimism of the will.”
Asst Prof. in Methods & Stats. Study longitudinal quantitative methods, learning, development, neural networks. 🏳️🌈
Welcome Trust research fellow at KCL IoPPN, working on computational psychiatry of mood and anxiety
https://thewiselab.org
Professor at Stanford. Psychology/Neuroscience/Data Science. Books include: The New Mind Readers, Handbook of fMRI Data Analysis, Hard to Break, and Statistical Thinking.
https://poldrack.github.io/
Professor of Clinical Psychology at LMU Munich
https://www.lmu.de/psy/en/persons/contact-page/thomas-ehring-c0f08419.html
The leading non-profit journal of brain imaging https://direct.mit.edu/imag
Professor, Semel Institute for Neuroscience and Behavior, UCLA (https://profiles.ucla.edu/lucina.uddin)
Director, Brain Connectivity and Cognition Lab (https://teams.semel.ucla.edu/bccl)
Available for academic career advice. I never said *good* advice.
LOEWE-Zentrum DYNAMIC
LOEWE Research Center DYNAMIC
Researching new perspectives on mental health. Project news, articles and events in English or German – depending on the subject.
https://www.dynamic-center.net/
Psychiatrist with philosophical interests | Conversations in Critical Psychiatry (Oxford University Press, 2024) | Psychiatry at the Margins www.psychiatrymargins.com
Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org
Neuroscientist, professor
AI guided tour - https://www.youtube.com/watch?v=fOORfzGjCTA
ENIGMA guided tour - https://www.youtube.com/watch?v=YNjP5nZsJyQ
Diffusion MRI of Brain Diseases - https://www.youtube.com/watch?v=i2jHFm0wcN0
www.sysneuro.org
Melbourne, Australia
Science is magic that works✨
Postdoc at Zucker Hillside Hospital/ Northwell Health
Risk and Resilience/ Individual Differences /Neuroimaging
https://katharinabrosch.com/
The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium is a network of 2500+ scientists across 47 countries working to discover factors that help or harm the brain. http://enigma.usc.edu
Professor of Computational Neuroscience/Neuroimaging
@uni-jena.de
https://neuro-jena.github.io/
https://neuro-jena.github.io/cat
Research director | @McGillU @Mila_Quebec @IVADO_Qc | My team designs machine learning frameworks to understand biological systems from new angles of attack
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
https://www.nature.com/neuro/
Doing cognitive neuroscience at Monash University, Melbourne, Australia. We investigate brains, networks, genes, models, cognition & disorders.
Associate Prof Leiden Uni. Studying mental health problems as systems. http://eiko-fried.com. Building an early warning system for depression at http://WARN-D.com.
