David Walzik

Mitohormesis links physical exercise and subsequent formation of reactive oxygen species to insulin sensitivity and antioxidant defense.

One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...

For more trending articles, visit ow.ly/Me2U50SkLRZ.

ICYMI:

PROSPECTS DFG Research Career Series: Emmy Noether Programme (in English) - 28/04/2025 - 1:15-2:45 p.m. CET

PhD candidates and postdocs of all disciplines: Would you like to lead an independent junior research group? In our online talk you will get first-hand information about the aims of our Emmy Noether Programme, its eligibility requirements and more. Questions welcome!
➡️ www.dfg.de/en/research-...

Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans Nature Metabolism, Published online: 07 April 2025; doi:10.1038/s42255-025-01249-2In humans, conception during cold seasons is shown to exhibit higher brown adipose tissue activity and adaptive thermogenesis, and lower body mass index and visceral fat accumulation in the offspring.

ICYMI:

Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis - Diabetologia Aims/hypothesis Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that serum obtained from individuals after high-intensity interval...

The exerkine meteorin Metrnl is a potential therapeutic target for preserving human beta cell function and survival in type 1 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Energizing immune cells Experiments in fruit flies reveal a mechanism that immune cells can use to control the availability of nutrients when fighting infections.

Fruit flies demonstrate a mechanism that immune cells can use to control the availability of nutrients when fighting infections.
buff.ly/NXOfE4a

X’s dominance ‘over’ as Bluesky becomes new hub for research Data indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover

'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'

Exercise training restores longevity‐associated tryptophan metabolite 3‐hydroxyanthranilic acid levels in middle‐aged adults Aim Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated ...

Check out our new paper now out in Acta Physiologica on the tryptophan metabolite 3-HAA in the aging and exercise context 👇
@50823zimmer.bsky.social @davidwalzik.bsky.social

onlinelibrary.wiley.com/doi/full/10....

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...

No evidence for Peto’s paradox in terrestrial vertebrates | PNAS Larger, longer-lived species are expected to have a higher cancer prevalence compared to smaller, shorter-lived species owing to the greater number...

Peto's Paradox—that cancer does not increase with body size of mammals—was wrong.
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains - Nature Communications Moreno-Justicia and colleagues report transcriptomic and proteomic pipelines to explore heterogeneity within human skeletal muscle fibers, identifying sources of fiber heterogeneity in healthy individ...

A deep dive into the heterogeneity of human muscle fibers using transcriptomics and proteomics, now online @naturecomms.bsky.social. This was an amazing collaboration between our team @wimderave.bsky.social and the team @adeshmukh.bsky.social

www.nature.com/articles/s41...

Pretty cool!

Cellular crosstalk in skeletal muscle? A surprising role for mast cells? Histamine as a signal transducer during exercise? Check out the story in @cp-cellmetabolism.bsky.social 🧵

@wimderave.bsky.social, @ugent-fge.bsky.social, @fwovlaanderen.bsky.social

www.sciencedirect.com/science/arti...

Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk Van der Stede et al. identified a role for mononuclear cells in the skeletal muscle microenvironment to steer the response to exercise. Mast cells locally secrete histamine during exercise, triggering...

New #Cell_Metabolism paper: Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk. #MyoBlue tinyurl.com/ymc5ha3w

As always this project wouldn’t have been possible without the support and input of many different people. Thanks a lot to all co-authors! (12/12)
@50823zimmer.bsky.social @niklasjoisten.bsky.social

All our generated datasets and the proteomics raw data files are publicly available with this preprint. To facilitate data mining with respect to this and upcoming projects, we are currently finalising an interactive website, which will be published alongside the article once it is accepted. (11/12)

World Health Organization 2020 guidelines on physical activity and sedentary behaviour Objectives To describe new WHO 2020 guidelines on physical activity and sedentary behaviour. Methods The guidelines were developed in accordance with WHO protocols. An expert Guideline Development Gr...

Our data also supports the WHO physical activity guidelines, which highlight exercise intensity as a relevant factor to maintain health: doi.org/10.1136/bjsp.... (10/12)

Physical activity and risk of infection, severity and mortality of COVID-19: a systematic review and non-linear dose–response meta-analysis of data from 1 853 610 adults Objective To quantify the association between physical activity and risk of SARS-CoV-2 infection, COVID-19-associated hospitalisation, severe illness and death due to COVID-19 in adults. Design A sys...

This is in line with epidemiological studies showing reduced disease risk and improved disease course in people performing high levels of physical activity (e.g., doi.org/10.1136/bjsp... and doi.org/10.1007/s402...). (9/12)

Overall, our results suggest that repetitive exposure to acute exercise bouts, especially HIIE, reshapes the proteome of PBMCs. As indicated by our VO2peak prediction, accumulation of these acute effects might culminate in immunological exercise adaption over time. (8/12)

We also leveraged our dataset to predict cardiorespiratory fitness and identified an immunoproteomic signature that was associated with VO2peak. Interestingly, several proteins associated with energy metabolism and immune function had a strong impact on VO2peak prediction. (7/12)

Some of these cell functions were shared across all clusters, which suggests that these "core immune effector functions" are regulated irrespective of the underlying protein kinetic. In contrast, others were unique to a specific protein cluster. (6/12)

We then carried on by unraveling the proteomic alterations induced by HIIE. Making use of soft clustering and gene ontology analyses we found 4 distinct protein clusters that contained numerous proteins associated with immune effector functions. (5/12)

These changes occurred despite identical immune cell mobilisation patterns between HIIE and MICE, suggesting that HIIE reshapes the proteome of PBMCs in a more pronounced fashion and that this process is independent of immune cell mobilisation. (4/12)

This is crucial considering that exercise-induced changes in PBMC composition might impact proteomic results. Interestingly, we observed >1,300 changes in the proteome of PBMCs after HIIE and only 64 changes in response to MICE. (3/12)

In this work we performed flow cytometry-based immune cell phenotyping and mass spectrometry-based proteomics to consider both, changes in peripheral immune cell counts and alterations in the PBMC proteome. (2/12)

Acute exercise rewires the proteomic landscape of human immune cells Exercise-driven alterations of the immune system are a key mechanism in the prevention and treatment of various diseases. Here, we performed mass spectrometry-based proteomics analysis on peripheral b...

Happy to share our new preprint, where we investigate the impact of acute exercise on the proteome of immune cell! Comparing high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), we found numerous proteins that were differentially expressed in PBMCs. (1/12)

✨New issue!✨

Check out the latest in #metabolism research from across all disciplines 🧫🐭👥

Read about #Obesity, #Diabetes, #Epidemiology, #Myokines, #Cancer, #Aging - and many more topics!

www.nature.com/natmetab/vol...

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...

#CardioSky #MedSky community, I am reposting this because posts are still being “liked”.
Pls “repost” if you like to share with others.