INOUE, Takeshi

Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints li…

Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation - ScienceDirect
www.sciencedirect.com/science/arti...

egal-1 and microtubules promote regeneration polarity in planarians Summary: The planarian head-tail regeneration choice requires selective activation of Wnt-inhibitory notum at anterior-facing wounds, a polarized process that requires an Egalitarian-like protein and ...

egal-1 and microtubules promote regeneration polarity in planarians | Development | The Company of Biologists
journals.biologists.com/dev/article/...

The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians Zoology; Phylogenetics; Evolutionary biology; Phylogeny

Paper out! Collaborative decoding of the Iberian ribbed newt genome in iScience

The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians: iScience

www.cell.com/iscience/ful...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells -- T cells, natural killer cells, and neutrophils. Here, we identify 'ruptoblasts', a previously unknown cytotoxic ...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...

SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying how stem cell fates are specified as neurons in an adul...

SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians | bioRxiv
www.biorxiv.org/content/10.1...

Genetic and Genomic Insights into Planarian Biology | Annual Reviews
www.annualreviews.org/content/jour...

Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl Cell tracing is an essential method for deciphering cellular processes during organ regeneration. We generated transgenic Iberian ribbed newts carrying the multicolor reporter Brainbow3.0 cassette un...

Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl - Hayashi - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....

2025年8月号｜日経サイエンス 天体物理学 特集：認知の原点を探る 人工知能がこれだけ発展しても，私たちはまだ自らの知能についてよく理解できていない。プラナリアの脳再生や動植物の賢い振る舞い，AIとロボットの関係など多様な視点から生物の認知機能を見つめ … 続きを読む →

「プラナリアの体が宿した"記憶"」
少しだけコメントさせていただきました。
www.nikkei-science.com/page/magazin...

Step‐by‐Step Protocol for Making a Knock‐In Xenopus laevis to Visualize Endogenous Gene Expression - Kagawa - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1111/...

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs Previous studies suggested the importance of the reciprocal interactions between residual tissues, which we refer to here as the “stump”, and the newl…

our paper is out!

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs - ScienceDirect
www.sciencedirect.com/science/arti...

Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea N6-methyladenosine (m6A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules. This post-transcriptional modification is essential in biological contexts ranging...

Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea | bioRxiv
www.biorxiv.org/content/10.1...

A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen - BMC Genomics Background The isolation of intact, high-molecular-weight genomic DNA (HMW gDNA) is essential for achieving complete genome assemblies. However, extracting HMW gDNA from a single individual of Dugesia...

A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen | BMC Genomics
bmcgenomics.biomedcentral.com/articles/10....

Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons During regenerative neurogenesis, neurons must be created in the right types and locations. Though regenerative neurogenesis is limited in humans, other animals use regenerative neurogenesis to faithf...

Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons | bioRxiv
www.biorxiv.org/content/10.1...

Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians POU4 homologs are involved in the development of sensory cell types across diverse species, including cnidarians, ascidians, and mammals. Whether these developmental regulators are reused during adult...

Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians | bioRxiv
www.biorxiv.org/content/10.1...

Frontiers | Planarian RNAi knockdown: feeding once might just be enough
www.frontiersin.orghttps//www.frontie...

Developmental onset of planarian whole-body regeneration depends on axis reset Booth et al. show that the planarian Schmidtea polychroa gradually gains its impressive regenerative abilities during development. While regeneration involves many factors, this study shows that the r...

Developmental onset of planarian whole-body regeneration depends on axis reset: Current Biology
www.cell.com/current-biol...

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro...

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - 2025 - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....

Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...

Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging
www.nature.com/articles/s43...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense Cytotoxic killing is an essential immune function, yet its cellular mechanisms have been characterized in only a few model species. Here, we show that planarian flatworms harness a unique cytotoxic st...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...

Temporal integration and active sensing of light in planarians Animal light sensing and processing are intimately connected to the design of the sensory apparatus, with eye-design a subject of longstanding interest. Understanding animal response to stimuli can el...

Temporal integration and active sensing of light in planarians | bioRxiv
www.biorxiv.org/content/10.1...

Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells - BMC Genomics Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...

Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells | BMC Genomics |
bmcgenomics.biomedcentral.com/articles/10....

Keratinocyte-driven dermal collagen formation in the axolotl skin - Nature Communications Type I collagen in the dermis is a major component of the skin, though how this collagen is formed and modified as remained unclear. Here they show that keratinocytes contribute to dermal collagen for...

Keratinocyte-driven dermal collagen formation in the axolotl skin | Nature Communications
www.nature.com/articles/s41...

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro....

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/abs/10.1...

Regeneration in the absence of canonical neoblasts in an early branching flatworm - Nature Communications Adult pluripotent stem cells, called neoblasts, are considered a defining feature of all flatworms. This manuscript shows that canonical neoblasts are absent in an early branching flatworm lineage, ra...

Regeneration in the absence of canonical neoblasts in an early branching flatworm

www.nature.com/articles/s41...

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration: Cell Genomics
www.cell.com/cell-genomic...

A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient. Planarians exhibit remarkable whole-body regeneration abilities. The formation of heads at forward-facing wounds and tails at rearward-facing wounds suggests an intrinsic tissue polarity guiding regen...

A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient. | bioRxiv
www.biorxiv.org/content/10.1...

Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4 Studies on Hox13, Fgf10, and Tbx4 mutant newts with hindlimb defects showed a novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4.

Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4 - Tozawa - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....

Urodele amphibian newt bridges the missing link in evo‐devo of the pancreas Background The pancreas exhibits diverse structures and roles across vertebrates. The pancreas has evolved to include both endocrine and exocrine cells, a change that occurred during the transition ...

Urodele amphibian newt bridges the missing link in evo‐devo of the pancreas - Morozumi - Developmental Dynamics - Wiley Online Library
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...

Reduced adult stem cell fate specification led to eye reduction in cave planarians - Nature Communications Evolutionary eye loss has occurred in multiple phyla in species that inhabit dark environments, but few of those species have been studied thus far. Here they show that cave planarians retain small fu...

Reduced adult stem cell fate specification led to eye reduction in cave planarians | Nature Communications
www.nature.com/articles/s41...

A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient. Planarians exhibit remarkable whole-body regeneration abilities. The formation of heads at forward-facing wounds and tails at rearward-facing wounds suggests an intrinsic tissue polarity guiding regen...

www.biorxiv.org/content/10.1...