Micha Sam Brickman Raredon

Tissue-level division of labor is coordinated across organs through universal programs and context-specific adaptations Fibroblasts, macrophages, and endothelial cells are common to most mammalian tissues, where they support homeostasis, repair, and immune regulation. Yet how they coordinate their functions across dive...

www.biorxiv.org/content/10.1...

#TissueEngineeredVascularGraft

#hiPSC #SmoothMuscleCell on 3-mm PGA tubular scaffold

Decellularized

Rupture pres 1200 mmHg
Suture retent str 120 g

Re-endothelialized⏩rat aortic graft 30 d
❎thrombus
Repop by host EC

#CircRes 2022 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

Excited to see this paper out @pnas.org

Microbial self-organization in response to self-made oxygen gradients! 🦠 🔄 🍥

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Macrophages display spatiotemporal specificity in intrahepatic cholangiocarcinoma and drive tumour progression via OSM and THBS1 https://www.biorxiv.org/content/10.1101/2025.10.02.679723v1

Standing by Our Colleagues in Gaza — A Plea to the U.S. Medical Community | NEJM In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate ch...

www.nejm.org/doi/full/10....

Standing by Our Colleagues in Gaza — A Plea to the U.S. Medical Community | NEJM In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate ch...

My friend Naftali Kaminski is an Israeli physician, a professor at Yale, and the child of Holocaust survivors. For me he is a model of absorbing his parents' stories intensely, looking the horror of the 20th century in the eyes, and drawing the lesson of radical empathy for the suffering of others.

Powerful and important piece by an outstanding physician, scientist, and human being @kaminskimed.bsky.social

pdf:

jeremymberg.github.io/jeremyberg.g...

Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.

"[F]rom the 1940s to the 1970s, a Bell Labs job was said to be just like working at a research university, except the pay was better, the equipment was more up-to-date, the machine shop was available for all your needs and you didn’t have to spend time teaching or applying for research grants."

Check out our latest in @cp-trendscancer.bsky.social where rockstar PhD student @laurarosenberg.bsky.social reviews cancer therapies known to induce innate immune responses through the reactivation of Transposable Elements.

YouTube video by WION French President Macron Speaks at German Unity Day Ceremony | WION LIVE

President Macron:
“We were very naive to leave our public space to social media networks controlled by US or Chinese companies that don’t share our interests and not interested in survival of our democracies.”
www.youtube.com/watch?v=MggN...

A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context Peskett et al. show that P-bodies and the Whi3 protein form distinct condensates as budding yeast cells age. Mixing of these condensates promotes senescence entry and primes cells to abort the pheromo...

A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context: Molecular Cell www.cell.com/molecular-ce...

yep. You can't make a 'better case' that convinces tyranny of the value of science since knowledge is tyranny's kryptonite.

United States Disappeared Tracker

public.tableau.com/views/United...

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

www.nature.com/articles/s41...

Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression https://www.biorxiv.org/content/10.1101/2025.09.24.678347v1

Lab-Made Mini Organs Could Transform Female Reproductive Medicine Artificial tissues that mimic the placenta, endometrium, ovary and vagina could point to treatments for common conditions such as preeclampsia and endometriosis

www.scientificamerican.com/article/lab-...

Lab-Made Mini Organs Could Transform Female Reproductive Medicine Artificial tissues that mimic the placenta, endometrium, ovary and vagina could point to treatments for common conditions such as preeclampsia and endometriosis

Organoids and female reproductive medicine
🧪 #ReproSky #Scicomm #Reproduction #ObGynSky
www.scientificamerican.com/article/lab-...

Our paper "Morphogen gradients can convey position and time in growing tissues" is now out in Newton ‪@cp-newton.bsky.social‬

Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.

AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance Cellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the ...

Entirely self-serving :), but here's one of my favorite papers from the lab, which I think you might enjoy: www.biorxiv.org/content/10.1...

How We Came To Know Earth | Quanta Magazine Climate science is the most significant scientific collaboration in history. This series from Quanta Magazine guides you through basic climate science — from quantum effects to ancient hothouses, from...

Hii! Last week Quanta published a project I've been working on all year — a special issue about climate science, or what research into climate change is revealing about how our planet works www.quantamagazine.org/how-we-came-...

Targeting tumor-associated carbohydrate antigens via “velcro-like” binding of lectins allows immunosuppression-resistant pan-cancer killing while ignoring normal tissues @cellcellpress.bsky.social @ucirvine.bsky.social
www.cell.com/cell/fulltex...

1/ I’m excited to share recent work on inferring cell-cell interactions using attention by @justjhong.bsky.social and me, supervised by @elhamazizi.bsky.social . Open the thread 🧵 for a brief overview of our method. bioRxiv link: www.biorxiv.org/content/10.1....

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA

10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

Cross-species👤🐷🐭 analysis of elastic or coronary artery mesenchymal cells in #Atherosclerosis

75% mesenchymal cells shared as
Contractile (ACTA2 CNN1 FLNA)-
Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2)
#SmoothMuscleCell states

www.biorxiv.org/content/10.1...

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics.

We applied this workflow to map precancerous lesions of the fallopian tubes.

More here: www.biorxiv.org/content/10.1...