Micha Sam Brickman Raredon

🔥🔥

"publication systems [should] distinguish between dissemination of results & communication of ideas, and optimize them separately. Results should be in explicit, machine-readable form, while narrative text serves as an interpretive layer for human readers" www.biorxiv.org/content/10.6...

this is a fantastic essay.

An except from the Atlantic

This is an excerpt from Peter Drucker’s autobiography that was featured in The Atlantic.

Frankfurt university’s faculty had been gathered, the Jews were forbidden to enter, and a lead scientist asked about funding.

Indeed, there was much for Nazi “science”.

cdn.theatlantic.com/media/archiv...

chatomics! new blog post: Understanding prcomp() center and scale Arguments for Single-Cell RNA-seq PCA divingintogeneticsandgenomics.com/post/unders...

Absolutely true. The values aren't really that hard.

[They are also in commonly read book such as the Bible and the Koran]

I have never ever been this burnt out, not even the pandemic did this much damage to my morale and energy. Higher education is a hellscape, in the gAI age. And so many of us seem unable to see this tech critically/through the lenses of labor/ethics/technofascism.

PRMT5 inhibitors actively promote metastatic progression of lung adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.01.30.702866v1

"You will understand me when I say that my Middle High German was my life. It was all I cared about. I was a scholar, a specialist. Then, suddenly, I was plunged into all the new activity, as the university was drawn into the new situation; meetings, conferences, interviews, ceremonies, and, above all, papers to be filled out, reports, bibliographies, lists, questionnaires. And on top of that were the demands in the community, the things in which one had to, was ‘expected to’ participate that had not been there or had not been important before. It was all rigmarole, of course, but it consumed all one’s energies, coming on top of the work one really wanted to do. You can see how easy it was, then, not to think about fundamental things. One had no time." "Those," I said, "are the words of my friend the baker. ‘One had no time to think. There was so much going on.’" "Your friend the baker was right," said my colleague. "The dictatorship, and the whole process of its coming into being, was above all diverting. It provided an excuse not to think for people who did not want to think anyway. I do not speak of your ‘little men,’ your baker and so on; I speak of my colleagues and myself, learned men, mind you. Most of us did not want to think about fundamental things and never had. There was no need to. Nazism gave us some dreadful, fundamental things to think about—we were decent people—and kept us so busy with continuous changes and ‘crises’ and so fascinated, yes, fascinated, by the machinations of the ‘national enemies,’ without and within, that we had no time to think about these dreadful things that were growing, little by little, all around us. Unconsciously, I suppose, we were grateful. Who wants to think?

"But your friends are fewer now. Some have drifted off somewhere or submerged themselves in their work. You no longer see as many as you did at meetings or gatherings. Informal groups become smaller; attendance drops off in little organizations, and the organizations themselves wither. Now, in small gatherings of your oldest friends, you feel that you are talking to yourselves, that you are isolated from the reality of things. This weakens your confidence still further and serves as a further deterrent to—to what? It is clearer all the time that, if you are going to do anything, you must make an occasion to do it, and then you are obviously a troublemaker. So you wait, and you wait. "But the one great shocking occasion, when tens or hundreds or thousands will join with you, never comes. That’s the difficulty. If the last and worst act of the whole regime had come immediately after the first and smallest, thousands, yes, millions would have been sufficiently shocked—if, let us say, the gassing of the Jews in ’43 had come immediately after the ‘German Firm’ stickers on the windows of non-Jewish shops in ’33. But of course this isn’t the way it happens. In between come all the hundreds of little steps, some of them imperceptible, each of them preparing you not to be shocked by the next. Step C is not so much worse than Step B, and, if you did not make a stand at Step B, why should you at Step C? And so on to Step D.

The parallel to this is how academics of Germany post-1933 experienced the rise of fascism & still did their research. Nazism meant new rules, new paperwork. You were just so busy, you barely had time to do research, of course you didn't have energy to protest

press.uchicago.edu/Misc/Chicago...

Violating hospitality is one of the oldest proscriptions across so many cultures.

LSU featuring our recent published research led by the amazing @josanesousa.bsky.social and @gabrielalima19.bsky.social www.nature.com/articles/s41...

Academics vying for a spot in Epstein‘s world. There are so many. I feel the need to make a thread, so I don’t keep confusing them. 1/

American Photographs
History of Scientific Medicine
Music Theory
Islamic Art & Architecture
Introduction to Materials Science

Epstein’s economic power among academics was made possible by a capitalist system that makes higher education dependent on the charity economy rather than a public good supported by taxing the rich

“We’re going to still be looking out for each other when they’re gone” On the ground with the Minnesotans standing up to ICE.

From @julialurie.bsky.social

www.motherjones.com/politics/202...

Lab culture 1. Give the work, and each other, 100%. 2. Do work that makes better things possible. 3. Treat the subjects of the work with respect. 4. Treat data with care. 5. Primary research before reviews. 6. Write, speak, and work in specifics. 7. Never stop reading. 8. Chop lettuce once a month. 9. Don't fight your work. 10. Ask for help when you need it! (And be respectful of your teammates' time) 11. Only start what you can finish. 12. Take ownership, give credit. 13. Be honest with the public. 14. Computers don't do your thinking. 15. No money from bastards.

“You can’t judge people for trying to fundraise from a convicted pedophile” yes you can idiot. I’m doing it right now with my big powerful scientist brain. It’s literally part of my lab rules

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging Mouse models revealed age-associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and rig....

Biomechanics and scRNASeq analyses reveal mechanisms & biomarkers of decreased exercise ability with aging.
👏🏼👏🏼👏🏼 MD PhD student Ruben De Man & Dr. Ed Manning for integrating physiology, single cell biology, aging, vascular biology so elegantly!!
onlinelibrary.wiley.com/doi/10.1111/...

Point of no returns: researchers are crossing a threshold in the fight for funding With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

"In other words, European taxpayers will have spent more on the funding process than on the funding itself, and the scientific ecosystem has been drained"

The situation is rapidly becoming unsustainable: the current research funding scheme does not work.

www.nature.com/articles/d41...

New in @dev-journal.bsky.social, “Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney” with Caramai Kamei, Iain Drummond & team.

🧪 🐟🎸 #ScientificResearchPublishing

doi.org/10.1242/dev....

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche - preLights The megakaryocyte: trapped in a cage of its own making

Insightful ‘postLight’ just uploaded by @simoncleary.bsky.social 👀

Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @elife.bsky.social

#postLight: prelights.biologists.com/highlights/m...

"How do class gaps compare to race and gender gaps? Strikingly, we find that the class gaps in tenure-track academia are as large as or larger than analogous race or gender gaps."

This is a chat box where you can try to yell at your paper until it is written.

DeepSpaceDB
genomics.virus.kyoto-u.ac.jp/deepspacedb/

>2k #SpatialTranscriptomics Visium samples

👉Interactive, downloadable data analysis
👉Cross-sample/Cross-study comparison
👉Analyze your own data
👉Database-wide gene/pathway inquiry

#NucAcidRes 2026
academic.oup.com/nar/article/...

Cartoon by Adam Zyglis

Well said.

YouTube video by Adrian Liston Lung Treg seminar

For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)

www.youtube.com/watch?v=o_X4...

The Normal Aging Lung Cell Atlas is finally out!!!
ScRNASeq reveals that lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing greatest changes in gene expression, somatic mutations burden, transcriptional entropy
www.nature.com/articles/s41...

Development of the blood–brain barrier

👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4

👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh

Circumventricular organ ❎BBB◀️WIF1

#Development 2026
journals.biologists.com/dev/article/...

So the question I have for Rausch (and for @radiofreetom.bsky.social, who I have a healthy respect for) is which of the italicized indicators here he thinks is but newly revealed; as far as I can tell, each was either a feature of Trump I or openly campaigned on as he ran for re-election

That was indeed a bone-chilling interview. And I'm grateful to @chrismurphyct.bsky.social for his morally sane response to moral insanity.