Julieth Murillo

Innate immunity of the lungs in homeostasis and disease www.mucosalimmunology.org/article/S193...

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !

@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr

www.sciencedirect.com/science/arti...

Intermanual transfer and the default mode network. In the study by Rezaei and colleagues, participants initially learned a sensorimotor task with their right hand (the initial learning phase). When they later performed the same task with their left hand (the transfer phase), they made fewer errors at first. Rezaei and colleagues found that brain connectivity patterns, especially those linked to the part of the default mode network (the red region), were notably similar during the early stages of the initial learning (green shaded area) and transfer (orange shaded region) phases. The brain image shows the medial surface of the left hemisphere.

Applying skills gained in one context to different situations enables efficient #learning, even from limited data. This Primer explores a @plosbiology.org study which shows that the #DefaultModeNetwork plays a key role in this ability 🧪 Paper: plos.io/41LOAWf Primer: plos.io/417aTpd

A simplified model of immune education. The model developed by Tepekule and colleagues incorporates key inputs such as maternal human milk oligosaccharides (HMOs) and IgA, infant diet, and endogenous IgA produced in the infant gut. These inputs are then modeled within the context of the infant gut lumen, where IgA can mask or neutralize microbial taxa, and HMOs and plant-derived polysaccharides selectively promote different taxa. Model parameters are informed by existing in situ longitudinal IgA-seq data and infant feeding records. The main outputs include the abundance and IgA binding levels of each modeled microbial taxon, allowing for predictions of how variations in inputs (e.g., changes in breastfeeding or diet) shape the developing infant microbiome.

Early immune education mechanisms remain poorly understood. This Primer explores a @plosbiology.org study which uses math modeling to provide mechanistic insights into how the infant #ImmuneSystem learns to distinguish beneficial & harmful #microbes 🧪 Paper: plos.io/4lsJ8i5 Primer: plos.io/4oHrDNI

Original paper: https://rupress.org/jem/article/222/10/e20250444/278135/Targeting-infection-specific-peptides-in Video summary by Owen Leddy (Massachusetts Institute of Technology) Description: One… Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery

New video summary 🎥 from Leddy et al. @thebrysonlab.bsky.social (rupress.org/jem/article/... ) on a new workflow called PathMHC that helps find pathogen-derived antigens presented on MHCs by infected cells that could be targets for T cell priming vaccines:

Mathematical modelling for biologists - Modelling concepts in biological research Mathematical modelling for biologists - Modelling concepts in biological research

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...

Including both molecular and epidemiological examples

The role of environmentally mediated drug resistance in facilitating the spatial distribution of residual disease Communications Biology - Mechanistic modelling of tumour-stroma crosstalk sheds light on how targeted drug dynamics and microenvironmental heterogeneity shape residual disease through distinct...

This paper took the scenic route to publication: paused for maternity leave, rerouted by other work priorities, and finally dusted off like a forgotten treasure in the attic when my brilliant student Amy came on board.

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

Challenges and opportunities for the next generation of computational tumor models Mathematical models have become essential tools for exploring the complex interplay between cancer cells and their microenvironment, but require multidisciplinary expertise and abundant biological dat...

Mathematical models are essential tools for exploring the complex interplay between #cancer cells and their environment, but require expertise and abundant data to develop. Lance Munn & Rakesh Jain suggest that #AI is leading the way towards the next wave of tumor models 🧪 plos.io/4ofREUk

Research Fellow - Department of Immunology and Immunotherapy - 106119 - Grade 7 The successful candidate will make extensive use of a range of in vivo models of fungal infection and will have access to the wide range of transgenic tools and in vivo immunology techniques establish...

Job ads for TWO postdoctoral positions available in our group are now online. Deadline August 25th.
🧪Immunologists, apply in link below.
🍄Microbiologists- please follow link in next post.
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. 🧵1/10

www.biorxiv.org/content/10.1...

Family hubs to open in every council in England Government says £500m plan aims to support an extra half a million more children.

Amidst the blizzard of news, this is hardly being reported but will make the biggest difference in peoples' lives www.bbc.co.uk/news/article...

NHS England » NHS waiting list hits two-year low as staff work to ‘turn the tide’ The NHS waiting list has fallen to its lowest level in two years, the first April drop since 2008*, as health chiefs hailed staff for continuing to tackle demand and drive progress for patients. New d...

“The NHS waiting list has fallen to its lowest level in two years, the first April drop since 2008”

www.england.nhs.uk/2025/06/nhs-...

From the same team that made vanilla for ice cream using E.coli that digest plastic waste.

🔬 Day 1 of the EMBO Practical Course on Computational Modelling of Multicellular Systems kicks off at the Collaboratorium!

Participants were welcomed by @jamesasharpe.bsky.social, setting the stage for a week of exploring how computational tools help us understand tissue and organ dynamics. 💻🧬

Polygenic scores (PGS) offer insights into a person’s inherited risk of disease.

GeneticScores.org is a new platform that enables secure, cloud-based calculation of polygenic scores to make genomic risk prediction more accessible.

www.ebi.ac.uk/about/news/u...

🖥️🧬

I've just heard our group of runners for @scotrefugeecouncil.bsky.social have almost raised a collective £15K!!!

We are just under £500 off our target!

My JustGiving page closes on Sunday... can we do it before?!!

All shares/donations count!

Thank you!! ❤️❤️❤️

www.justgiving.com/page/amy-mci...

Assistant Teaching Professor and Course Director, MPhil in Translational Medical Research (Fixed Term) - Job Opportunities - University of Cambridge Assistant Teaching Professor and Course Director, MPhil in Translational Medical Research (Fixed Term) in the Department of Medicine at the University of Cambridge.

🚨New vacancy at @cam.ac.uk🚨

The Department of Medicine at the University of Cambridge is looking for an Assistant Teaching Professor and Course Director for the new MPhil in Translational Medical Research.

📩 Apply by 22 June:

🚨 Abstract Deadline - Friday 30th May

There are 10 days left to submit your abstract for EMDS2025. We have >20 selected talk slots - so submit an abstract today!

All details & programme: www.emds2025.com

@britsocimm.bsky.social @societymucosalimm.bsky.social @cytokinesociety.bsky.social

Latin-American genetic data available securely to approved researchers worldwide/Datos genéticos latinoamericanos disponibles para investigadores de todo el mundo

Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a...

Cohort description: www.ctsu.ox.ac.uk/research/pro...

A promotional flyer for the AI@MBL: Machine Learning for Microscopy Image Analysis course at the Marine Biological Laboratory. Course dates are Aug 22 to Sept 6, 2025, with applications due April 30. The image includes a brief paragraph: "This two-week course will familiarize researchers with state-of-the-art deep learning techniques for microscopy image analysis." The image also includes the hashtag #ScienceStartsHere, a logo for the MBL, and an abstract image with different colored blobs.

⚠️ Course deadline extension ⚠️

The last day to apply for the AI@MBL course this summer is now April 30!
📲 Read more and apply: bit.ly/43vIT0u

#ScienceStartsHere

Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis. https://www.biorxiv.org/content/10.1101/2025.04.13.648617v1

Join us for this @dgz.bsky.social seminar online with very cool talks about the Cell biology of the immune system

There will be of course some #CellMigration of leukocytes ;)

Speakers: @liz-kurtz.bsky.social, #ZahraaA, @labliston.bsky.social and #StefanU

A flyer for the MBL Falmouth Forum series. It has the date, time, and location of the event (Friday, April 11, 7:30pm, Cornelia Clapp Auditorium), a photo of speaker Paul Catanzaro with info on him (professor, State Extension Forester, co-director of the Family Forest Research Center, UMass Amherst), a link to the join the talk virtually, a logo for the MBL, and information on how the forum series is supported.

📆 Don't forget to join us TOMORROW, Friday, April 11, for a special MBL Falmouth Forum with Paul Catanzaro!

His talk will begin at 7:30 p.m. in the MBL's Lillie Laboratory. Can't make it in person? That's okay, we'll be streaming live! mbl.edu/falmouth-forum

OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...

Do any of my #tbsky friends have interests in T cell responses in people with evidence of prior Mtb infection?

If so, would you have any interest in looking at T cell responses to Mtb-derived peptides that we have detected by mass spectrometry? LMK 🙏🏽

📄 Update on our preprint about Gene Regulatory Net (GRN) benchmarking 📄
We have included the original and decoupled version of SCENIC+, added a new metric and two more databases. Dictys and SCENIC+ outperformed others, but still performed poorly in causal mechanistic tasks.
doi.org/10.1101/2024... 👇

😮 I feel seen.

Graphical abstract of BioChatter

Applying LLMs to biomedical research today can go one of two ways: we either use a closed-source web app, or we get coding ourselves. Many researchers lack training for the latter, so their only choice is the former. We want to change that. www.nature.com/articles/s41...

Organoids have incredible potential in drug discovery and disease modelling.

In this Scientific Computing World interview, @iguaracy.bsky.social discusses organoid construction, nanobots, and how bioinformatics is transforming biomedical research.

www.scientific-computing.com/article/usin...