Tomáš Heger

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.

We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

Check out this fascinating study on a fungal multipass translocon! What's really neat is how they did it: cryo-EM structure from the endogenously tagged and purified SND3 complex. It will be exciting to see if there is any potential for SBDD against fungi, Trypanosoma, and Leishmania (?).

Structural basis for selective inhibition of human GABA transporter GAT3 The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state!
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Yes, please. I go with Nemesis drones and like their motto "to see means to win":
www.dronynemesis.cz/en.

I am very grateful that you were my opponent and joined us in Aarhus, also giving such an interesting lecture on the SND pathway! I really enjoyed it a lot.

Oh yeah, P-types ❤️💙💛 and the copper one, ATP7B!

It was a great day full of science. Thank you so much everyone for being involved!

Thank you very much, Charlott, for these kind words and for being such a great supervisor!

Thank you so much, Thibaud. It was so great that I could start this journey with you, I am very grateful for that.

Thank you so much for guiding me on this amazing journey, @poulnissen.bsky.social, @charlottstock.bsky.social, and @tdieudonne.bsky.social. So great and thorough discussion with @melaniemcdowell.bsky.social, @henrietteautzen.bsky.social and Daan van Aalten. I highly appreciate your involvement.