Stephen Floor

I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with

congrats and excited to dig in!

Translation efficiency covariation identifies conserved coordination patterns across cell types - Nature Biotechnology Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.

Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41...

A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...

Predicting the translation efficiency of messenger RNA in mammalian cells Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:

Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l

Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!

watch out for the proximity mine near that door

“With these considerations, we expect to fund through the 4th percentile.”

There it is, in black and white, the destruction of cancer research in the US.

The Tyranny of Merit: Can We Find the Common Good? Can We Find the Common Good?

apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity”

bookshop.org/p/books/the-...

this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why

the vibes seem off

super curious what these people are like irl, like are they arguing with someone in the grocery store because they're buying organic (or not organic)? someone at the gas station who chooses low octane fuel? someone at a pharmacy who's getting vaccinated? or are they just internet warriors

great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!

This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!

absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours

whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica
radios-de-costa-rica.com/1031-fm

Trump’s Cuts to N.I.H. Grants Are Illegal, Federal Judge Rules The judge accused the Trump administration of discriminating against minorities and L.G.B.T.Q. people and ordered the government to restore much of the funding.

A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG

the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president

Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸

Racism and xenophobia is already turning the US into a backwater to avoid

Sonicator - living the @infinitescream.bsky.social dream

people will literally die because of this

"all the best" 💩🤡

I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏

fully agree - the real question is: will Trump let the DOGEs out?

These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.

right but the pairwise is underpowered to detect differences across the series and one has to correct for multiple testing on the individual points. I’m sure you’re doing this I just see a lot of … not doing it

local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli

this is the best way I’ve seen, I’m thankful for this thread so maybe there will be less of doing a t-test on each time point and labeling each with asterisks

if the US wants to be competitive on the world stage, investing in education, science, and technology is the way. one doesn’t simply discriminate your way to the top

prelim phase 1/2 trial results of the Moderna H5N1 vaccine program included no (none) dose-limiting toxicity and 97.8% (NINETY SEVEN POINT EIGHT PERCENT) of participants reaching protective antibody levels. defunding this program makes America sicker endpts.com/trump-axes-m...