Jorge Huete-Carrasco

(3) This work highlights the importance of combining cancer vaccines with immunotherapies to improve treatment outcomes.

A huge thank you to everyone involved in this project!

(2) This polymeric formulation with adsorbed antigen significantly reduced tumour growth and prolonged survival in mice bearing hot or cold tumours. We also observed a synergistic effect when combined with anti-PD-1 immune checkpoint blockade.

(1) We show that adsorption of antigen to polymeric nanoparticles is essential for inducing antigen cross-presentation by conventional type 1 dendritic cells (cDC1s), leading to enhanced CD8⁺ T cell-mediated immunity. Furthermore...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Therapeutic cancer vaccines require CD8+ T-cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for....

Delighted to share that the latest work from #EdLavelle and me at @tcddublin.bsky.social @tbsi-tcd.bsky.social on the rational design of CD8⁺ T cell-inducing adjuvants for cancer vaccines has been published in Immunology and Cell Biology #Wiley.

🔗 onlinelibrary.wiley.com/doi/10.1111/...