@timmunologist.bsky.social
Professor of Immuno-Oncology University of Oxford interested in antigen processing, T cells and interception vaccines for cancer.
@blackwellbooks.bsky.social please start posting
20.07.2025 06:42 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0Great to see our work on preventive cancer vaccines, including LungVax, featured in this issue!
@oxfordcancer.bsky.social @sarahblagden.bsky.social @timmunologist.bsky.social
Join us for our DPhil in Cancer Science Open Day on Tuesday 2nd September at 12:30pm to find out how a DPhil can be the next step in your cancer research career development!
Register via our Eventbrite link before 1st Septโฌ๏ธ @oncology.ox.ac.uk @medsci.ox.ac.uk
www.eventbrite.co.uk/e/university...
Looking forward to talking about #cancervaccines to *all* @CRUK research and innovation staff this afternoon at their fabulous away-day. Actually Iโm a bit nervous๐ฌ
17.07.2025 11:26 โ ๐ 8 ๐ 0 ๐ฌ 1 ๐ 0Amazing news for our Institute @kiroxford.bsky.social @ox.ac.uk ๐๐พ๐ ! Looking forward to working with our @manchester.ac.uk colleagues to understand better how envrionmental determinants drive chronic inflammatory diseases !
16.07.2025 21:15 โ ๐ 5 ๐ 1 ๐ฌ 0 ๐ 0
Targeting monocyte dynamics in MS?
In Immunotherapy Advances, Bibi et al. explore how shifting monocytes from inflammatory to reparative states may reshape MS treatment strategies.
๐ https://bit.ly/3EXOfaV
#MS #Monocytes #Neuroinflammation
New research by Rui Zhao et al. shows that high anti-drug antibody (ADA) levels after 3 cycles of camrelizumab are linked to shorter survival in patients with advanced solid cancers.
๐ Higher ADA = lower drug levels = worse outcomes.
๐ https://bit.ly/461mc5B
#Immunotherapy #CancerResearch
๐งฌ Better understanding of immune rejection and evasion is setting the stage for next-gen therapies.
Elizabeth Simpson reviews how foundational immunology is reshaping transplant and cancer treatment.
๐ https://bit.ly/44N141N
#TransplantImmunology #Immunotherapy
๐งฉ Antigen presentation is complex - but imaging is bringing clarity.
@doreenlau.bsky.socialโฌ & @timmunologist.bsky.socialโฌ review how advanced imaging illuminates T-cellโAPC interactions, peptide-MHC dynamics, and more in cancer immunity.
๐ https://bit.ly/3TkIasN
#CancerImmunology
A high-affinity TCRxCD3 bispecific (ImmTACยฎ) efficiently redirects T cells to kill PRAME+ tumor cells, even at low epitope density. Combination with anti-PD-1 restores activity in exhausted T cells.
One of the most read articles in ITA: https://bit.ly/40o5kT8
#immunology
Mechanistic modelling reveals that both antigen-dependent and independent factors shape CAR T-cell dynamics in month-one lymphoma patients. IL-7/IL-15 levels and lymphodepletion matter more than CAR T-cell phenotype.
๐ Read: https://bit.ly/3U6fDY6
#Immunotherapy
Yesterday we finished with prize-giving and drinks in the garden๐ฅ๐ฑ! ๐ Posters for Bas, Cindy & Charlotte๐; postdoc talk for Qian ๐ฉโ๐ซ & best embossing artwork for Group8 ๐งโ๐จ Shoutout to Lisha for the Rhodes House tours, acknowledging its history, the good and the uncomfortable โ๏ธ. What a day! #CIOawayday
10.07.2025 07:15 โ ๐ 3 ๐ 3 ๐ฌ 0 ๐ 0
โจ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers ๐งโ๐ฌ๐ฉโ๐ฌ๐งซ A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas ๐ค Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO ๐๐ #ScienceLife
09.07.2025 11:37 โ ๐ 7 ๐ 5 ๐ฌ 0 ๐ 2
๐ฌ Call for papers: We invite submissions for a special collection on Immunotherapies for Inborn Errors of Immunity.
Explore genetics-guided, targeted treatments for primary immunodeficiency and immune dysregulation.
๐๏ธ Submit by Sept 2025
๐ Info: https://bit.ly/40o5kT8
#Immunotherapy
#Bridge2ABetterFuture Challenge #10 complete with sueduncombe.bsky.social - the @cancerresearch.uk.org Big Hike (Cotswolds). 14 miles over the hills in the heatwave! Big steps bringing big discoveries Thanks for all donations fundraise.cancerresearchuk.org/page/bridge-... @oxfordcancer.bsky.social
12.07.2025 16:46 โ ๐ 2 ๐ 2 ๐ฌ 0 ๐ 0Wonderful personal perspective from one of the founders of modern immunology
05.07.2025 06:43 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
๐จ Last chance!
Just a few days left to submit to our Special Collection: Imaging in Immunotherapy.
Showcase your research in molecular imaging, immune monitoring, and image-guided drug delivery.
Deadline: June 2025 ๐งฌ๐ผ๏ธ #Immunotherapy #MolecularImaging
๐ฉ Submit now: https://bit.ly/4j8c265
๐จ Researchers at over 120 UK institutions can publish open access for free in Immunotherapy Advances!
No APC's, just impactful immunotherapy research shared with the world. ๐ #OpenScience
๐ Check eligibility here: bit.ly/4no9OTy
๐ซ New study: M2 macrophages ease asthma symptoms in mice by boosting IL-10โบ B-cell production via the TGF-ฮฒ & oxidative phosphorylation pathways.
๐ก Highlights the regulatory role of macrophageโB cell interactions in asthma.
๐ Read more: https://bit.ly/4kXzogj
A big part of the CIO team will be at #BSI2025 ๐ค especially now that our very own Max from the @ggillesp.bsky.social lab is featured on the conference poster! Looking forward to an exciting few days in Liverpool ๐ฌโจ #Immunology #CIOonTour
26.06.2025 10:09 โ ๐ 6 ๐ 2 ๐ฌ 0 ๐ 0
And we're off!
Conference Co-Chair and @oncology.ox.ac.uk's Professor of Experimental Oncology @sarahblagden.bsky.social opens day two of the Cancer Prevention Research Conference in London.
Intramolecular Active displacement of common MHC I- peptide interactions drives peptide editing. Thanks for the call out Chris!
26.06.2025 08:09 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0Really important to see the research generating a solid and powerful evidence base needed to help governments undo health inequalities
25.06.2025 18:17 โ ๐ 4 ๐ 0 ๐ฌ 0 ๐ 0Itโs under publicised that MANY universities and institutions around the world can publish in ITA for FREE under the read and publish deals with OUP. There are still inequalities - especially painful for BRIC who have great research infrastructure but no R&P deals yet. I hope this will change.
25.06.2025 18:12 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications https://www.nature.com/articles/s41576-024-00774-2 (read free: https://rdcu.be/dVNV4)
02.10.2024 15:30 โ ๐ 6 ๐ 3 ๐ฌ 0 ๐ 0
Great panel discussion chaired by our own @timmunologist.bsky.social on 'the role of immune dysfunction in cancer development and prevention' at today's Cancer Prevention Research Conference! @cancerresearchuk.org @americancancersoc.bsky.social
25.06.2025 14:38 โ ๐ 4 ๐ 1 ๐ฌ 0 ๐ 0Immunology x cancer prevention = exciting research x healthy living
25.06.2025 15:20 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Feeling proud and looking sharp!
Repping the Centre for Immuno-Oncology in style ๐
๐ฅOur top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!
Team spirit (and outfits) on point ๐๐ค๐
๐ What do we really know about DC3s in solid tumors?
This new article explores the phenotype, function & impact of DC3s across cancers - highlighting their complex roles in both immunity & immunosuppression.
๐ Read it now: https://bit.ly/3T2blRg
#Immunotherapy
