John Foley

Very excited to see this story out in Science Signaling!!

Especially the use of dose-dependent profiling at different time points could clearly separate immediate from late and consequential signaling changes in KRAS-driven (phospho)proteomes.

Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling Proteomic analyses offer insights into how KRAS inhibitors affect oncogenic KRAS signaling.

Excited to share our latest work published in #ScienceSignaling! 🚀
www.science.org/doi/10.1126/...
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Whither Colbert? Whither Democracy Mass media are dead: corrupted, complicit, malign, worthless

In which I wish @stephencolbert.bsky.social would start an internet empire. And for the first time, I tell the tale of trying to help Howard Stern start his.
Whither Colbert? Whither Democracy medium.com/whither-news...

Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins The kinase RIPK3 suppresses pathologic neuroinflammation in mouse models of flavivirus infection.

Excited to announce that our collaboration with @briandaniels.bsky.social has been published today! So happy for everyone involved, but especially me and Marissa 😆. Check it out if you're interested in #neuroinflammation and the #BBB www.science.org/doi/10.1126/...

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s disease–linked LRRK2-mutant mice LRRK2 inhibition restores a cilia-dependent, neuroprotective signaling circuit in Parkinsonian mice.

Features a recent study by Jaimon et al. in Science Signaling:

Scientists Succeed in Reversing Parkinson’s Symptoms in Mice The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments.

English translation...

Científicos logran revertir síntomas del Parkinson en ratones; ¿podrán hacerlo en humanos? El número de casos de Parkinson en el mundo podría superar los 25 millones para 2050, lo que representaría un aumento del 112% respecto a las cifras de 2021.

🧪 #neuroscience

Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib Oligomerization renders the oncoprotein TEL-ABL insensitive to the ABL inhibitor asciminib.

🧪In Science Signaling this week, Muratcioglu et al. (Kuriyan lab, Vanderbilt) show that although the oncogenic fusion proteins BCR-ABL and TEL-ABL are both sensitive to tyrosine kinase inhibitors, only BCR-ABL is sensitive to the allosteric ABL inhibitor asciminib. #cancer

The image shows immunohistochemical staining of an astrocyte marker (magenta), cell nuclei (cyan), and Zika virus (yellow) in infected mouse cortical brain tissue.

Don’t miss this week’s new issue of #ScienceSignaling!

A proinflammatory protein can also suppress inflammation in astrocytes during flavivirus infections, new research shows that fusion proteins that drive leukemia aren’t equally susceptible to an approved drug, and more.

scim.ag/40GXJz9

Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins The kinase RIPK3 suppresses pathologic neuroinflammation in mouse models of flavivirus infection.

🧪In Science Signaling, Lindman et al. (Daniels lab, Rutgers) show that the kinase RIPK3 plays an anti-inflammatory role in astrocytes during flavivirus infection in mice. RIPK3 induces the production of Serpin3AN, which protects BBB integrity, limiting immune cell infiltration. #Neuroinflammation

Senior biomedical reporter position open here at Science. One of the best crews in science journalism. Join us! Job details at bit.ly/44Rk8uR

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Evolution of growth factor signaling to the TSC complex to regulate mTORC1 Structural and evolutionary insights are discussed about how the primary brake on mTORC1 activity is lifted.

🧪 We have a new Review this week in Science Signaling by @bdmanning.bsky.social and colleagues on the structure and evolution of the TSC complex, which acts as a brake on #mTORC1.

#FluorescenceFriday & Erythroblast

Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue).

Captured via Correlative Light & Electron Microscopy by
@jemimaburden.bsky.social

Learn more: scim.ag/4kTxFZz
@antalpedro.bsky.social
@jffoley.bsky.social
@science.org

Radha Maurya, a 10-month-old living in the village of Nausahara, Nepal, is being treated for severe wasting.

The United States reneged on its foreign aid commitments. Nepal’s malnourished children and their families are paying the price.

Learn more in this week's issue of Science: scim.ag/46cnJFO

Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway The ER-resident Ca2+ sensor STIM2 may suppress colorectal cancer tumor progression and metastasis.

🧪 In Science Signaling this week, Pathak et al. show that loss of the calcium sensor STIM2, but not STIM1, correlates with poor prognosis in patients with colorectal cancer (CRC). In mice, loss of STIM2 drove CRC progression and metastasis in a manner independent of Orai calcium channels. #CRC

The new Rubin Observatory and its LSST survey will provide a torrent of data for time-domain astronomy, reports @danclery.bsky.social. 🧪🔭☄️

It's the cover story for the current print issue of @science.org; the animations in the online version are even more impressive!
www.science.org/content/arti...

🧪 Check out ImmunoChannels, a website/platform for researchers interested in ion channels and transporters in immunity. Kudos to Stefan Feske and team for putting this together. #Immunology

immunochannels.org

Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.

Our new paper uncovering the role of Plexin/Semaphorin signaling in collective cell migration using testis nascent myotubes in flies is out! This work is from my time with @peiferlabunc.bsky.social led by @maikbischoff.bsky.social. As always, I am so thankful and proud to be a part of this story!

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

🧪 In Science Signaling, Julia Gutjahr, Antal Rot, and colleagues show that CXCL12-CXCR4 signaling in bone marrow erythroblasts drives their differentiation and the production of red blood cells in mice, suggesting that this pathway might be targeted to treat erythrocyte pathologies.

Eleanor Maguire (1970–2025) - Nature Neuroscience Eleanor Maguire was a visionary cognitive neuroscientist whose research transformed our understanding of how the brain supports memory, navigation, and imagination.

🧪 "She was a devoted mentor to many, deeply committed to shaping the next generation of researchers. Her team mantra was “We want to plant seeds, not prune hedges” — always encouraging her colleagues to think critically and aim high."

“It’s common sense, and it’s good science,” said Bhattacharya, whose agency has no involvement in the regulation of vaccines, or in decisions on who should get them.

Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling Disease-causing Gαs variants reduce GPCR signaling by affecting distinct G protein activation steps.

🧪 This week in Science Signaling, Maria Marti-Solano, Graham Ladds, and colleagues investigated two mutant forms of GalphaS associated with pseudohypoparathyroidism type Ic, finding that different signaling steps can be altered by specific GalphaS mutations associated with the same disease.

#GPCRs

Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry Community-suggested best practices for the analysis of oxylipins are presented.

🧪 Almost 100 researchers across 70 institutions, including academia, industry, and clinical laboratories, have developed new recommendations for analyzing oxylipins by LC-MS/MS. Hopefully, these guidelines will improve reproducibility in research. Read their article this week in Science Signaling:

The Continuing Crisis, Part XIV: The Trumpist Worldview

The Continuing Crisis, Part XIV: The Trumpist Worldview | Science | AAAS www.science.org/content/blog...

An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases The bacterial serine-threonine kinome is a resource for functional studies and drug development.

🧪In Science Signaling this week, O'Boyle et al. analyzed the sequences of more than 300,000 bacterial serine-threonine kinases and classified them into different families. This resource helps us to understand the evolution of eukaryotic kinases and may aid antibacterial drug development. #kinases

🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by
@vesselman.bsky.social

🧠🧪 Check it out: www.science.org/toc/signalin...
@cuanschutz.bsky.social

Front cover of Science Signaling journal with a micrograph of fluorescently labelled neuromuscular junctions (NMJs)

There are still few better feelings as an academic than when your paper’s image is chosen for the front cover of a journal #ProudPI #NMJ Confocal micrograph taken by the amazing @drchayts.bsky.social