Jim Mansfield

#histopathology #tissueclearing #lightsheetmicroscopy #postdoc #sciencecareers #munich | Ali Maximilian Ertürk Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️ My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues. ...

Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️

My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues.
More info: www.linkedin.com/posts/ali-ma...

Here is the whole Trump, Brexit, Russia story neatly summed up for you

The battle started about Ukraine, now it’s about big tech monopoly power

PXD055846 🚨

Benchmarking of mass spectrometry-based antibody repertoire profiling reveals extensive systematic biases

🚨 New dataset alert! 🚨

NOVA | Ancient Desert Death Trap | Season 52 | Episode 17 Explore mysterious 9,000-year-old Stone Age megastructures found in the Arabian Desert.

Discovery of an ancient neolithic people in the Arabian desert that built scaled models of their large animal traps!
www.pbs.org/video/ancien...

Letter from Congress to FDA re: undermining vaccines, page 1 of 6

If the Texas plaintiffs want us to overturn the new congressional maps, they are welcome to come back and prove that they would actually favor Democrats.

by John Roberts (joined by Thomas, Alito, Gorsuch, Barrett, and Kavanaugh)

A heroin addict who writes bad porn poetry says eliminating the Hepatitis B vaccine will make kids healthier. Medical experts say it will kill thousands of innocent children. For busy parents, it can be hard to know who to believe.

RFK’s Anti-Vax Team Readies Its Next Moves “Their game is, let’s really destabilize trust in the vaccine, and make people really anxious about it.”

It's notable that, even in an article critical of RFK Jr., the reporter hedges, saying "There’s no good evidence of serious, widespread harm from the vaccine" rather than just "vaccines are safe." RFK Jr. has made a career of exploiting the ambiguity of the former.
www.thebulwark.com/p/rfk-anti-v...

This distal gill tip is giving full branchial art vibes for #FluorescenceFriday 🦓🐟
— who knew oxygen exchange could be this pretty.
🔴 kdrl:mCherry highlights the vasculature
⚪ fgf10b:nEOS marks the pillar cells

#Zebrafish #DevBio #SciArt

No one could’ve predicted that putting a lot of Opus Dei weirdos on the Supreme Court would end our democracy

A spokesman for the Department of the Defense insists that Secretary Hegseth tried to contact the survivors on the Venezuelan boat by Signal chat several times before firing the second missile.

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.

www.nature.com/articles/s41...

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article) A quiet policy change means the government is making fewer bets on long-term science.

While the administration has said it is cutting “woke programs” that “poison the minds of Americans", it actually funded fewer grants in every area of science and medicine.

“They brought everything to a stop,” said Sarah Kobrin, a branch chief at the N.I.H.’s National Cancer Institute

Great culture can save lives. Literally.

Amazing letter in today’s @thetimes.com about Tom Stoppard

The NIH grant cuts in 2025
www.nytimes.com/interactive/...

Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

You now need a Real ID to board a plane. But fortunately for House Republicans, you still don’t need one to transport a minor across state lines.

Our paper on the second Berlin patient came out in Nature today and I’m really happy we can share this story on World AIDS Day. I want to thank everyone on the team and all co-authors for their work over the years.

www.nature.com/articles/s41...

Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis Abstract. Background: Disparate results in the immunohistochemistry literature regarding the relationship between biomarker expression and patient outcome

First out in 2002! Here's the first big paper from David Rimm.

academic.oup.com/jnci/article...

But modern methods can do a lot more with more markers and more comprehensive analysis

AQUA papers are rare these days!

Quantitative Spatial Profiling of PD-1/PD-L1 and TIGIT/CD155 Interaction Indicates Poor Survival Outcome and Resistance to Adjuvant Chemotherapy in Pancreatic Adenosquamous Carcinoma Pancreatic adenosquamous carcinoma (PASC) is a rare, highly aggressive pancreatic cancer. Its therapeutic response varies, presumably due to tumor mic…

Quantitative Spatial Profiling of PD-1/PD-L1 and TIGIT/CD155 Interaction Indicates Poor Survival Outcome and Resistance to Adjuvant Chemotherapy in Pancreatic Adenosquamous Carcinoma 🧪 #PancreaticCancer www.sciencedirect.com/science/arti...

Discover novel IO targets and biotherapeutics! Attend tomorrow's AI, Upcoming Technologies, and Potential Applications #webinar to gain valuable insights for predicting patient responses to immunotherapy. Learn more and register: https://ow.ly/R6Uq50XA2uX

Comparative analysis of commercial Imaging-based #SpatialTranscriptomics methods

Xenium
CosMx 1k
MERSCOPE

Tissue Microarray
17 tumor+16 normal tissue

Transcript count
vs Reference RNAseq
Segmentation accuracy
Cell type annotation

#NatComms 2025
www.nature.com/articles/s41...

Quantification of the radiative forcing of contrails embedded in cirrus clouds - Nature Communications This study presents a quantification of the global mean net radiative forcing of contrails in cirrus clouds equal to 5 mW m−2, obtained from matching aircraft positions with spaceborne lidar data. Thi...

New study shows that the global mean net radiative forcing of #contrails in #cirrus #clouds is equal to 5mW m−2, suggesting that embedded contrails are a non-negligible part of the #climate impact of #aviation. www.nature.com/articles/s41...

@shifaant.bsky.social @srinivas-lab.bsky.social peaking into the chick heart - love it!!

Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination

PNAS www.pnas.org/doi/10.1073/...

But ... Stanley is 6'8"! <sigh>

Antimicrobial resistance: a silent pandemic SPONSOR FEATURES

This week is World #AntimicrobialResistance Awareness week

This article collection spans the breadth of #AMR across pathogens (bacteria, viruses, fungi, parasites), covers epidemiological monitoring, diagnostics, treatment, etc

Breaking character: I am open to the idea the media's coverage of Biden's age and mental acuity was fair or perhaps not even tough enough. But the fact that it was so much tougher than the coverage of Trump's (more severe) mental decline is damning and I can't see how anyone could argue otherwise.

In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...

www.wsj.com/health/healt...