Marc van Oostrum

Erin M. Schuman Wins 2026 Nakasone Award

🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social ‬#neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P

Congratulations! The new Advanced Grant winners are great news.
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!

We are accepting applications for a PhD opportunity at @scilifelab.se

this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.

A EU funded generous fellowship is offered with possibility of industry experience. Apply here:

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

We are using Synaptophysin in vivo and in vitro, mostly because we had good experiences with the Ai34D mouse line- you can get the AAVs from the repository at vvf.ethz.ch. For minimal effects I‘d consider the Synaptotagmin intrabody but haven‘t tried it.

Cover of journal Neuron shows a female scientists turning lamp-like neurons on and off

"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt...
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence

🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025!

🎉Congratulations to all other prize winners！

👏 Warm congratulations to the organizers on the successful completion of the event!

#proteomes #proteomics

Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...

We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.

www.biorxiv.org/content/10.1...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM

Understanding which proteins work together Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing...

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...

New Preprint out !

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...

Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more

Short thread below 🧵1/4

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator Proteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi...

50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social !
www.biorxiv.org/content/10.1...

On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.

Exciting paper - lots of things to discover in the data and the approach!

The SNSF urges against cuts In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.

❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness.

➡️

❗Gravierende Folgen für die Schweizer Wirtschaft und Gesellschaft: Der SNF fordert den Verzicht auf die im «Entlastungspaket 27» vorgesehenen Kürzungen bei der Forschungsförderung. Diese würden die Innovationskraft und Wettbewerbsfähigkeit des Landes gefährden.

➡️https://buff.ly/eorZPvl

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

My lab at CUHK (QS: 36th) is hiring!
We are looking for motivated Research Assistants, PhD students (urgent🚨) and Postdocs who love solving problems. To understand the mysterious brain, we use a range of fun techniques. Please spread the word and get in touch if you are interested!

Global analysis of protein turnover dynamics in single cells The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

Flow Cytometry Operator/Specialist at the FACS Core Facility (FCF) of the Biozentrum, University of Basel (60-80%)
www.biozentrum.unibas.ch/open-positio...

@biozentrum @unibas.ch #Biozentrum #Basel #research #science #joboffer #hiring #cytometry #operator

Discover and follow the announcement of the Brain Prize 2025 winners today, March 5th, here: brainprize.org

Impressive & insightful study! Reminds me of this nice figure from Aebersold & @mannlab.bsky.social 2016

Synapse-astrocyte proximities differ across synapse types! Exciting insights into synaptic diversity from the Helmstaedter lab at @mpibrain.bsky.social

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!

Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...

We have #postdoc openings in proteomics and structural+computational+cell biology. We offer cutting-edge infrastructure and an interdisciplinary engaging environment.

Check out our ongoing research and recent papers at www.theliulab.com

Interested? Message me here or at www.theliulab.com/contact

Gilles Laurent is awarded the Louis-Jeantet Prize for Medicine in 2025 The 2025 Louis-Jeantet Prizes are awarded to Gilles Laurent, director at the Max Planck Institute for Brain Research in Frankfurt and to Veit Hornung, professor at the Ludwig Maximilian University of ...

Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6ie

Increased resolution for the discovery of newly synthesized cell-type specific proteomes in vivo!