Marc van Oostrum

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA

www.science.org/doi/10.1126/...

co-first with: @andschwarz.bsky.social

with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more

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#MolBio 🧪

Autismus - Neuronale Besonderheiten und neue Behandlungswege

#EinblickeBiozentrum by @scheiffelelab.bsky.social
December 16, 2025.

Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird.

ow.ly/Wkme50RbjZc

Well, looks like we need to start asking for mass spec validation of western blots

Thank you to 250+ participants, our keynote speakers, and the Event Forum team for an inspiring Swiss Dementia Forum.

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

Erin M. Schuman Wins 2026 Nakasone Award

🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social ‬#neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P

Congratulations! The new Advanced Grant winners are great news.
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!

We are accepting applications for a PhD opportunity at @scilifelab.se

this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.

A EU funded generous fellowship is offered with possibility of industry experience. Apply here:

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

We are using Synaptophysin in vivo and in vitro, mostly because we had good experiences with the Ai34D mouse line- you can get the AAVs from the repository at vvf.ethz.ch. For minimal effects I‘d consider the Synaptotagmin intrabody but haven‘t tried it.

Cover of journal Neuron shows a female scientists turning lamp-like neurons on and off

"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt...
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence

🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025!

🎉Congratulations to all other prize winners！

👏 Warm congratulations to the organizers on the successful completion of the event!

#proteomes #proteomics

Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...

We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.

www.biorxiv.org/content/10.1...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM

Understanding which proteins work together Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing...

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...

New Preprint out !

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...

Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more

Short thread below 🧵1/4

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator Proteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi...

50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social !
www.biorxiv.org/content/10.1...

On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.

Exciting paper - lots of things to discover in the data and the approach!

The SNSF urges against cuts In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.

❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness.

➡️

❗Gravierende Folgen für die Schweizer Wirtschaft und Gesellschaft: Der SNF fordert den Verzicht auf die im «Entlastungspaket 27» vorgesehenen Kürzungen bei der Forschungsförderung. Diese würden die Innovationskraft und Wettbewerbsfähigkeit des Landes gefährden.

➡️https://buff.ly/eorZPvl

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

My lab at CUHK (QS: 36th) is hiring!
We are looking for motivated Research Assistants, PhD students (urgent🚨) and Postdocs who love solving problems. To understand the mysterious brain, we use a range of fun techniques. Please spread the word and get in touch if you are interested!

Global analysis of protein turnover dynamics in single cells The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

Flow Cytometry Operator/Specialist at the FACS Core Facility (FCF) of the Biozentrum, University of Basel (60-80%)
www.biozentrum.unibas.ch/open-positio...

@biozentrum @unibas.ch #Biozentrum #Basel #research #science #joboffer #hiring #cytometry #operator