Nick DeVito

How multispecific molecules are transforming pharmacotherapy - Nature Reviews Drug Discovery Multispecific drugs are designed to engage two or more entities to exert their pharmacological effect. This Perspective discusses how a new wave of FDA-approved multispecific molecules have been trans...

How multispecific molecules are transforming pharmacotherapy
www.nature.com/articles/s41...
rdcu.be/ezbK0

This new article by Raymond Deshaies discusses how a wave of drugs designed to engage two or more entities are overcoming development barriers such as toxicity, rapid clearance and redundancy

A Not-So-Fond Farewell to Vinay Prasad The Steve Urkel of COVID Twitter turned out to be incompetent at both drug regulation and being an authoritarian apparatchik

Angie Rasmussen takes a blowtorch to Vinay Prasad #scicomm

‘Congress has your back’: US senators tell scientists they want to protect NIH budget Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.

A US Senate committee endorsed maintaining the NIH's structure and increasing its funding by US$400 million, or about 1%

go.nature.com/4mg193S

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

Hidden in the lungs of some breast cancer survivors are tumor cells that can remain dormant for decades — until they one day trigger a relapse.

Now, experiments show for the first time these rogue cells can be roused from their slumber by common respiratory illnesses such as COVID-19 or the flu.

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year

Chokes off billions in research funding

Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

Ultraprocessed food intake and increased risk of lung cancer thorax.bmj.com/content/earl...

“[Vought’s] footnote stipulated that the agency’s funding for the remainder of the fiscal year could only go to staff salaries and expenses, not to new grants or certain grants that are up for renewal. Most NIH-funded research is done by outside scientists at labs across the country.”

no words

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

New Science story about multi-year funding and it potential catastrophic consequences

www.science.org/content/arti...

1/n

American Association of University Professors calls on Duke to 'immediately halt' its employee buyout program The statement, signed by AAUP president Todd Wolfson, alleges that Duke did not consult faculty and staff in decision-making prior to rolling out the VSIP and has not been transparent with its cost-cu...

"[The @aaup.org] also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff."

www.dukechronicle.com/article/2025...

“With these considerations, we expect to fund through the 4th percentile.”

There it is, in black and white, the destruction of cancer research in the US.

Ozzy! You will be missed, one of rock’s icons.

Black–White disparities across the colorectal cancer care continuum in the USA Nature Reviews Gastroenterology & Hepatology, Published online: 21 July 2025; doi:10.1038/s41575-025-01087-3In the USA, colorectal cancer (CRC) is a leading cause of death and a public health challenge due to persisting disparities between Black and White individuals. This Review examines Black–White disparities in CRC outcomes, bringing health-care and systemic inequities into focus.

ICYMI: New online! Black–White disparities across the colorectal cancer care continuum in the USA

They were more decent that expected

Nice view and nice Weber, the cover band reminds me of the time i saw Dread Zeppelin in the keys

World’s Premier Cancer Institute Faces Crippling Cuts and Chaos - KFF Health News After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%.

After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%. kffhealthnews.org/news/article...

lol #microplastics

A JAMA study examined how US children’s health across a broad spectrum of indicators has changed from 2007 to 2023.

Lead author Christopher B. Forrest, MD, PhD, from @childrensphila.bsky.social shared key insights from the findings with several media outlets. 🧵

ja.ma/44NrNKz #MedSky

The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics
@naturemedicine.bsky.social
nature.com/articles/s41...

BOT+BAL trial for MSS CRC: Dr. DeVito - Colontown University In this DocTalk, Dr. Nicholas DeVito broke down the promising 1L BOT + BAL trial and explained the current state of immunotherapy for MSS colorectal cancer. Recorded in June, 2025. https://youtu.be/Kw...

I recently gave a doc talk for COLONTOWN on tumor immunology and immunotherapies like BOT/BAL, highlighting our first-line investigator initiated trial in MSS CRC. Appreciate the invitation to speak and opportunity to listen to patient/supporter questions!

learn.colontown.org/topic/botbal...

Worse Survival and Gastrointestinal Toxicity Outcomes Among Patients Receiving Proton Pump Inhibitors During Checkpoint Inhibitor Therapy - PubMed Our study is the largest to date showing the impact of PPI use on immunotherapy toxicity. PPI use may predispose to more severe toxicities and worse outcomes. PPIs may also reduce immunotherapy effica...

Patient receiving immunotherapy while on proton pump inhibitors (PPIs) had worse survival and higher rates of GI toxicity. Another drug to avoid or at least try to limit during immune checkpoint inhibitor treatment.

pubmed.ncbi.nlm.nih.gov/40533069/

Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...

Diagnosis Young: Doctors see link between lifestyle, cancer diagnoses As early-onset cancer diagnoses surge among young people, doctors and researchers are urgently exploring potential causes including environmental and dietary factors, with ultra-processed foods and se...

The WRAL team did an excellent job highlighting our work at Duke in YOGI, the Young Onset Gastrointestinal cancer Initiative

www.wral.com/news/investi...

Diagnosis: Young, The New Face of Cancer in NC "Diagnosis: Young, The New Face of Cancer in NC" is the latest investigative documentary from the WRAL Doc unit, exploring the alarming trend of cancer striking younger adults in North Carolina and ac...

www.wral.com/story/diagno...

From bodybuilding to beating cancer: Trials, treatment put woman on road to remission Despite her commitment to fitness, Bianca Harvey received a life-altering cancer diagnosis at age 34. Now Harvey's treatment has her cancer shrinking by over 50%, offering hope for remission.

Bianca’s resilience continues to amaze us - her story is below and the full documentary on young people braving a cancer diagnosis airs tonight (WRAL):

www.wral.com/news/investi...

Following court order, NIH ceases new terminations of politically sensitive grants After a judge told agency to restore hundreds of killed grants, NIH backs off plans to cancel more existing projects

Breaking news: The National Institutes of Health has ceased terminating grants on politically sensitive topics after a federal judge ruled last week that the cancellations were illegal.
scim.ag/4l9MO8Y

Diagnosis: Young, The New Face of Cancer in NC Behind every personal story is the big question: Why is this happening?

This Thursday, WRAL’s documentary on Young People Facing Cancer airs at 7:30 pm. I hope you can watch this important segment - my patient and I contributed to this timely story.

www.wral.com/story/diagno...

Proper cloth, reda merino in particular

His custom cancer therapy is in an NIH freezer. He may not get it in time. The purge of probationary federal workers included skilled lab personnel who would have finalized a customized cell immunotherapy for cancer patients.

Richard is a metastatic cancer patient whose life could be saved by a custom cell therapy — one that is currently sitting unused in a freezer because of Trump's NIH cuts.

Yet another example of the real impacts of the Trump Admin's attacks on science and our federal workforce.

Research funding has unexpected benefits. A lizard study led to Ozempic In a new weekly video series, STAT's @HoganAlex examines the stakes of ongoing court battles over NIH grant funding.

A tizard study led to a drug now used by millions.
Yet federal cuts threaten that spark—and with it future innovation.
Don’t destroy the seeds of change & growth. Protect public research.

zurl.co/QhSRQ

Since we all probably need some palate cleansers in our timelines today, here are some carnivorous plant photos from Wilmington NC- venus fly traps only grow within 100 miles of here, no where else in the world!