Nick DeVito

Scoop: FDA vaccine chief’s memo cited 10 pediatric Covid-19 vaccine deaths—but the agency’s own analysis found 0–7. Dr. Vinay Prasad circulated a memo before FDA scientists finished their work. His conclusions overshot what the agency’s own analysts ultimately found.

Prasad, Makary and others who claim that COVID19 vaccines killed 10 children are not telling the truth.

According to @jeremyfaust.bsky.social, the committee that worked on this question reported that there were ZERO deaths that they were certain were caused by the vaccines.

Well worth reading.

Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

The biggest clue to cranks that there is no vaccine conspiracy is that Doctors and Scientists continue to vaccinate their own children at record rates.

Save the date: Saturday, March 14th, 2026 join us for the CRUSH Colorectal Cancer 5K at The River Church in Durham.

Support our patients, advocates/caregivers, researchers, and community at this incredible event - You will not want to miss our speakers!

"Never spread the lie in the headline" should be a hard rule of 21st century journalism.

Research shows that repeating lies helps to spread them, and people read headlines more than they read stories.

Prostaglandins in tumor immune response are often overlooked (a ‘been there done that’ mentality) - but there remains tremendous therapeutic opportunity in understanding this fundamental pathway.

As I spent more and more of my life under the care of doctors, nurses, and researchers striving to improve the lives of others, I watched as Bobby cut nearly a half billion dollars for research into mRNA vaccines, technology that could be used against certain cancers; slashed billions in funding from the National Institutes of Health, the world's largest sponsor of medical research; and threatened to oust the panel of medical experts charged with recommending preventive cancer screenings. Hundreds of N.I.H. grants and clinical trials were cancelled, affecting thousands of patients. I worried about funding for leukemia and bone-marrow research at Memorial Sloan Kettering. I worried about the trials that were my only shot at remission. Early in my illness, when I

Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia.

www.newyorker.com/culture/the-...

US Governors Launch Multistate Public Health Coalition This Medical News article discusses a new state-led coalition, called the Governors Public Health Alliance, to bolster disease detection and response as federal support wanes.

Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance.

Here’s what to know about the new coalition.

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues - Nature Communications Wang, Huang, Nelson, Gao, and colleagues perform a head-to-head comparison of multiple platforms for imaging spatial transcriptomics, determining their relative sensitivity, specificity, and ability t...

www.nature.com/articles/s41...

Neutrophil extracellular traps in cancer - Nature Reviews Cancer Neutrophil extracellular traps (NETs) influence cancer initiation, progression and metastasis through immunosuppressive mechanisms within the tumour microenvironment. In this Review, Shahzad et al. highlight our recent understanding of NET biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.

#Review🚨
Spicer & team highlight our recent understanding of neutrophil extracellular traps #NETs biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.
📖 👇

T cell nomenclature diagram titled "T cell nomenclature: from subsets to modules" shows existing and alternative modular T cell nomenclature with examples. Text includes descriptions of T cell types and functions.

A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪

Guidelines for T cell nomenclature - Nature Reviews Immunology This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

..cross your 't's folks.. here's how!

www.nature.com/articles/s41...

ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling

Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...

The irresistible rise of libertarian eugenics Social Darwinism is making a comeback in the US — this time wrapped in the language of freedom

Great.
"Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics."
www.ft.com/content/23e9...

Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy - PubMed The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome-heat shock protein 70 (HSP70) signaling axis is triggered by CD8⁺ T cell cytotoxicity and contributes to the development of adaptive resistance to anti-programmed cell death protein 1 (PD-1) immunoth …

Neat. More evidence for the role of TLR4 in metastasis.

pubmed.ncbi.nlm.nih.gov/36417489/

Way to call out these thieves, perfect line.

Management of MSI-H CRC Including New Data From ESMO 2025 A video from Nicholas Devito (as part of Duke Cancer Institute), posted on Oct 31, 2025.

My overview of MSI-H colorectal cancer management post ASCO and ESMO, aka “the ATOMIC diss track,” is up on VuMedi:

www.vumedi.com/video/manage...

Next week LinkedIn will use your personal data for AI training by automatically enabling permissions.

To manually turn off go to:

Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off

Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home

Yes definitely and we have a spectral sorter here now, so more users soon.

I will contact flowjo w/our core!

Thanks again for posting this - have you reached out to FlowJo about adding it as an R plugin?

Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...

YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial - Nature Medicine As presented at the European Society for Medical Oncology Congress 2025: In patients with locally advanced or metastatic solid tumours, including mesothelioma, treatment with a first-in-class inhibito...

YAP is a tough drug target with implications in resistance to immunotherapy and other treatments, these are some very encouraging results

www.nature.com/articles/s41...

YouTube video by DukeCancerInstitute Immunology for Oncology Fellows Faculty and Pharmacy Residents

The tumor immunology and immunotherapy lecture "Know the System Know the Drug,” that Dan Schrum and I recorded for trainees, is up on YouTube!

If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk.

m.youtube.com/watch?v=atiS...

America’s brain drain

No words

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression https://www.medrxiv.org/content/10.1101/2025.10.06.25337175v1

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis Tertiary lymphoid structures (TLS) and B cell infiltration are strong predictors of immunotherapy success across cancers, including triple-negative breast cancer (TNBC). However, immune-cold TNBCs oft...

Lactate impairs TLS formation - nice pre print www.biorxiv.org/content/10.1...

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine