Christian Peace

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

28.07.2025 15:02 — 👍 84    🔁 27    💬 7    📌 0

Are you interested in #immunometabolism but not sure where to start?

Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now.

shop.elsevier.com/books/metabo...

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10.07.2025 15:26 — 👍 24    🔁 8    💬 1    📌 2

Elegant work on complex I and ROS in macrophages

19.02.2025 20:28 — 👍 2    🔁 0    💬 0    📌 0

Aged Mice Exhibit Widespread Metabolic Changes But Preserved Major Fluxes Metabolic dysregulation is a hallmark of aging. Here we investigate age-induced metabolic alterations in mice using metabolomics and stable-isotope tracing. Cir

Hello aging/metabolism people. I have a preprint now available about metabolic fluxes in aged mice. Please read and feel free to share ^_^
papers.ssrn.com/sol3/papers....

27.12.2024 15:30 — 👍 2    🔁 1    💬 0    📌 0

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

17.01.2025 11:16 — 👍 38    🔁 15    💬 4    📌 2

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports imageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory macrophage polarization. This study shows that respiratory inhibition is not required for macropha...

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports

www.embopress.org/doi/full/10....

06.01.2025 15:58 — 👍 33    🔁 13    💬 0    📌 0