Alex Tatara, MD PhD's Avatar

Alex Tatara, MD PhD

@amtatara.bsky.social

Physician scientist engaged in biomaterials, immunoengineering, and device-related infection. Assistant prof at UTSW.

1,911 Followers  |  175 Following  |  36 Posts  |  Joined: 21.11.2023  |  1.9455

Latest posts by amtatara.bsky.social on Bluesky

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Patient-reported perceptions, experiences and preferences around intravenous and oral antibiotics for the treatment of Staphylococcus aureus bacteremia: a descriptive qualitative study.

βœ… Just Accepted
#IDSky
πŸ”— https://bit.ly/3Iil2JB

27.09.2025 20:50 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 0    πŸ“Œ 11
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Testing for Sexually Transmitted Infections in Symptomatic Male Military Trainees AbstractIntroduction. A high burden of sexually transmitted infections (STIs) exists among trainees entering United States Air Force Basic Military Trainin

My team’s new article is out!

For male basic trainees who had ICD-10 code for UTI or dysuria:

~50% had a sexual history documented
~70% had a gc/ct test ordered,
-Ultimate diagnosis of gc/ct >>> uti
-Few had any STI testing in 3 years following dysuria

#IDSky

academic.oup.com/milmed/advan...

10.08.2025 22:26 β€” πŸ‘ 17    πŸ” 2    πŸ’¬ 3    πŸ“Œ 1
Implant Infectious Diseases: An Introduction to Biomaterials for ID Physicians AbstractImplanted biomedical devices are becoming ubiquitous in the practice of medicine but are at risk for biofilm-related infection. The biomaterial composition of these devices can significantly affect their risk for infection. Biomaterials design is complex with compositional choices leading to different properties, including mechanical strength, biodegradation rate, and ability to locally release therapeutics. In this review, we introduce the field of β€œImplant Infectious Diseases,” review practical biomaterial fundamentals for the infectious disease clinician, and apply these principles to case vignettes. This review serves as a primer for a broad infectious disease audience to better understand the role of biomaterials in medical devices and as therapeutics.

Implanted devices risk biofilm infections. Biomaterial design affects infection risk, strength, and drug release. This review aids infectious disease clinicians in understanding biomaterials. πŸ¦ πŸ’‰

#idsky

06.08.2025 20:30 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Many thanks for highlighting our work and giving us the opportunity to talk about the exciting intersection between host, microbe, and biomaterial!

14.07.2025 18:48 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We had a wonderful time looking at biomaterials through the lens of ID! Thanks for the RT

14.07.2025 11:46 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
[Articles] Incidence of health-care-associated infections in long-term care facilities in nine European countries: a 12-month, prospective, longitudinal cohort study This study shows the high incidence of HAIs among LTCF residents in EU or EEA countries, with more than one in two residents experiencing at least one HAI, and with RTIs and UTIs accounting for almost half of all observed HAIs.

πŸ“Š Over 50% of LTCF residents in EU/EEA have HAIs. RTIs & UTIs make up nearly 50% of these infections.

#idsky

17.06.2025 10:30 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Many thanks to Jay Vyas for writing such an insightful commentary to our article in Clinical Infectious Diseases- pubmed.ncbi.nlm.nih.gov/40470539/.

12.06.2025 12:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congrats to our fantastic ID fellow (Dr. Hannah Blanchard) and ID Faculty (Dr. Hayden Andrews, Dr. Netanya Utay) on their timely publication in @cidjournal.bsky.social on Measles immunity at our HIV clinic!! πŸ‘
academic.oup.com/cid/advance-...

@bradcutrellmd.bsky.social @netanyautay.bsky.social

04.06.2025 01:51 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

The disappointment after trying to buy dinosaur Elvis taught me a lot of life lessons

19.04.2025 18:25 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I remember playing this for hours at our library!! Can’t wait to watch…

19.04.2025 18:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

So neat! Do we know why?

17.04.2025 02:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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@steventong.bsky.social presents the results of the PSSA domain of the SNAP 🫰 trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025

fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA

12.04.2025 14:44 β€” πŸ‘ 76    πŸ” 33    πŸ’¬ 2    πŸ“Œ 2

We’ve got something in review that addresses this question (as much as observational data can). Basically we think all ASPs the same compared to cefazolin

12.04.2025 20:48 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0
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Dr Steven Tong presents data on Penicillin vs (Flu)Cloxacillin for penicillin sensitive S.aureus.

1. Penicillin is non-inferior.
2. Rate of AKI roughly half in Penicillin group.
3. More pts in Penicillin group changed Rx - why?
#ESCMIDGlobal

12.04.2025 15:13 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 1    πŸ“Œ 1

#ESCMIDGlobal starts soon πŸ€“
There's a new latebreaker session created to give 2-3 'big' trials their due: 'Trial Run', Sat 16:15
2 #SNAP trials + CloCeBa trial will be discussed in real detail Moderators @vancefowler.bsky.social +Julia Bielicki. @gurujosh.bsky.social @steventong.bsky.social #IDSky

08.04.2025 14:33 β€” πŸ‘ 37    πŸ” 7    πŸ’¬ 5    πŸ“Œ 1
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Staphylococcus aureus Bacteremia: A Review This narrative review summarizes current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of Staphylococcus aureus bacteremia.

Staphylococcus aureus bacteremia has a case fatality rate of 15% to 30% and causes 300 000 deaths per year worldwide. This Review discusses management of S aureus bacteremia. https://ja.ma/3RF8b50

07.04.2025 15:35 β€” πŸ‘ 24    πŸ” 9    πŸ’¬ 0    πŸ“Œ 2
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Models of Musculoskeletal Infection Care: The Importance of Multidisciplinary Collaboration

We reviewed the latest in ID/Ortho collaborative models- institutional investment is important! www.sciencedirect.com/science/arti... @utswinfdis.bsky.social

06.04.2025 19:33 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

SFB2025*

01.04.2025 01:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
LinkedIn This link will take you to a page that’s not on LinkedIn

Come join us! Hiring a postdoc to work on immunotherapy to prevent and treat orthopaedic infection. I'll be at SFB2015 in Chicago if you want to chat about life in Dallas at our fabulous program. lnkd.in/evpKR5KE
lnkd.in/e7K2PMgh

01.04.2025 01:41 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections Pyogenic musculoskeletal infections, such as septic arthritis and osteomyelitis, require prompt recognition and treatment but can be challenging to distinguish from Lyme or inflammatory arthritis. Our goal was to identify cytokine biomarkers of musculoskeletal infections.MethodsUsing 2 multicenter prospective cohorts of children undergoing emergency department evaluation for musculoskeletal infection, we selected children ≀21 years of age with a musculoskeletal infection (cases) matched by age and sex to children with Lyme and inflammatory arthritis (controls). We performed a 45-cytokine/chemokine panel using the Olink proximity extension assay platform and used receiver operator curve analysis to evaluate the discriminative ability of each cytokine. Using forward stepwise logistic regression, we derived a 3-cytokine panel and compared the accuracy with 5 commonly available plasma biomarkers.ResultsWe included 47 children with musculoskeletal infection, 48 with Lyme arthritis, and 49 with inflammatory arthritis. Interleukin-6 had the highest accuracy for musculoskeletal infection (area under the curve [AUC], 0.84; 95% CI, 0.77–0.91). A 3-cytokine biosignature panel (interleukin-6, interleukin-17A, and colony stimulating factor–1) had the highest overall accuracy (AUC, 0.90; 95% CI, 0.84–0.96) and performed better than 5 common plasma biomarkers (white blood cell count, absolute neutrophil count, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin; P < .05 for all comparisons).ConclusionsPlasma cytokines can distinguish musculoskeletal infections from Lyme or inflammatory arthritis and may assist initial decision-making for children undergoing evaluation for musculoskeletal infection.

πŸ” Study on 47 kids with musculoskeletal infections vs. 48 Lyme & 49 inflammatory arthritis. A 3-cytokine panel (IL-6, IL-17A, CSF-1) had AUC 0.90, outperforming 5 common biomarkers (P < .05).

#idsky

01.04.2025 00:00 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Welcome to the ROADMAP Trial – Examining treatments for PJI Explore our website to learn more about our trial, team, and how you can get involved in shaping the future of PJI treatment.

Excited to announce that we randomised our first patient in the @roadmaptrial.bsky.social today! First of thousands, answering important questions in prosthetic joint infection. See roadmaptrial.com for more deets. #IDSky #PJI #ROADMAP

24.03.2025 10:16 β€” πŸ‘ 35    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0
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Association of daily body temperature, white blood cell count, and C-reactive protein with mortality and persistent bacteremia in patients with Staphylococcus aureus bacteremia: a post-hoc analysis of... AbstractIntroduction. Classification of patients with Staphylococcus aureus bacteremia (SAB) as complicated versus uncomplicated is based on a combination

Post-hoc analysis of πŸ“· πŸ“· study in MSSA/MRSA bacteremia:

Persistent fever = indicator for complicated infection

Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)

🚫 assn between ⬆️CRP/WBC and mortality

#IDSky

academic.oup.com/ofid/advance...

31.01.2025 02:33 β€” πŸ‘ 37    πŸ” 14    πŸ’¬ 2    πŸ“Œ 0

β€œI’ll give you something to diarrhea about”

24.01.2025 00:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Risk Factors for Infection-Attributable Mortality in Patients With Staphylococcus aureus Bacteremia: A Competing Risk Analysis

In OFID, Seongman Bae and colleagues elucidate risk factors associated with 30-day infection-attributable mortality in a large cohort of patients with Staphylococcus aureus bacteremia (SAB).

09.01.2025 17:01 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Agreed! Just thought may be less inconvenient than micafungin infusions if that was an option you were considering

05.01.2025 15:46 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Haven’t used it and not ideal, but maybe rezafungin?

04.01.2025 22:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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【Mayo Clinic CME Orthopedic Infectious Diseases 2025】

πŸ‘‰Comprehensive #OrthoID learning course is coming soon!

πŸ‘‰Great learning opportunity for #IDFellow #IMResident #OrthoResident!

ce.mayo.edu/orthopedic-s...

#IDMedEd #IDFellow #OrthoID #MayoClinicINFD #MSIS #EBJIS

31.12.2024 01:41 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
2024 NIH Research Highlights - Promising Medical Findings NIH findings with potential for enhancing human health include insights into the mechanisms of ME/CFS, a skin test to detect Parkinson’s disease and related disorders, and a promising target for catar...

#NIH funding is vital and the returns are superb, as noted by critical translational breakthroughs relevant to chronic fatigue, Parkinson's, prior diseases, cataracts, and hearing loss made with NIH funding in 2024
www.nih.gov/news-events/...

27.12.2024 17:26 β€” πŸ‘ 22    πŸ” 11    πŸ’¬ 0    πŸ“Œ 2

@amtatara is following 20 prominent accounts