David Vilchez

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

A host organelle integrates stolen chloroplasts for animal photosynthesis Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

www.cell.com/cell/abstrac...

A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis

Fluoreszenzfärbung von Neuronen unter einem Mikroskop mit grünen und blauen Markierungen auf dunklem Hintergrund.

🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠

@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.

flourescent picture of motor neurons dyed green and blue (nucleus).

🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab ‪@sedakoyuncu.bsky.social‬ @unicologne.bsky.social‬ @cecad.bsky.social‬ ‪@ibv-csic.bsky.social‬ ‪@nataging.nature.com‬‬‬‬‬‬

We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging.
Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects.
👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.

In C. elegans & human cells, we found that age-related EPS8/RAC signaling hyperactivation promotes pathological aggregation of fifferent proteins (polyQ, FUS, TDP-43).
Decreasing EPS8 (or tuning RAC signaling) prevents aggregation & and neurodegeneration.

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

FEBS Press Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Shuttle and stabilize: H1.2-FUS complex in amyotrophic... : Neural Regeneration Research An abstract is unavailable. This article is available as a PDF only.

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis
journals.lww.com/nrronline/ci...

I was just wondering the same thing, given the number of recent papers along these lines

A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk

Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social

Vilchez Lab Curious to see what we do? Check out our research summary video:  https://youtu.be/kalsrf1ZbQ0

Hi Dani, I would really appreciate it if you can add me to the Science feed:
www.davidvilchezlab.com
scholar.google.com/citations?us...

Learning a lot and having fun at the #OpenDay #Science @cecad.bsky.social @mpiage.bsky.social

The project will be carried out at the CECAD Research Center (University of Cologne): @unicologne.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social

Postdoc Position (f/m/x) We are looking to support our rapidly growing team as soon as possible:

We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

🤪🤪🤪🤪🤪🤪🤪🤪🤪

Felicidades!

C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...

Thanks Barak😉

The study is part of the CRC1678 consortium;) @crc1678.bsky.social

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.

Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.

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New work from our lab;)

Thank you Oded!

Happy to have you aboard, Bjoern!

Finally;) Congrats, David! Well-deserved!

Thank you Maria!

Thank you Coleen!

Congrats Maria!