@mesthergallardo.bsky.social
Head of the Translational Research with iPS Cells Group. Hospital 12 de Octubre Research Institute, i+12. Madrid, Spain. Focus on: rare diseases
Celebrando la semana de la Ciencia e Innovación ✨️😊
04.11.2025 21:28 — 👍 2 🔁 1 💬 0 📌 0
Happy to share our latest open access paper "3D Printing of Chitosan Scaffolds and Films with Varying Roughness for Cultivation of Human Retinal Progenitor Cells" | ACS Omega pubs.acs.org/doi/10.1021/...
A great collaboration between RISE PFI, imas12 and UCM ✨️👌
On monday 29th, was the closing meeting of the bioMAT4EYE project a multidisciplinary European initiative to develop new biomaterials for human induced pluripotent stem cells differentiation into retinal ganglion cells. Thanks to all consortium members, funders, and the M-ERA.NET initiative.
30.09.2025 20:32 — 👍 1 🔁 1 💬 0 📌 0Science4Peace Seminar: The Responsibility of Scientists 🧪🕊️
Join Dr Philip Webber for a discussion on ethics in science, and the responsibilities of scientists from the Manhattan Project to modern WMDs.
📅 Wednesday 16th July, 2025 | 🕔 5pm CEST
us02web.zoom.us/meeting/regi...
Representative retinal sections from WT and cKO animals
👁️ Rod photoreceptors (your eye's light sensors) need more than sugar to survive.
A new study shows they rely on glutamine to stay healthy. This Insight Article explains the research and how this opens new doors for therapies to slow retinal degeneration.
buff.ly/vAHuvsF
Be inspired at the ISSCR 2025 Annual Meeting! Join us in Hong Kong from 11-14 June and expand your horizons by bringing new tools, ideas, and technology back to your lab to use in your own research. 👉 www.isscr2025.org
29.05.2025 20:55 — 👍 3 🔁 2 💬 0 📌 0
Diagram illustrating sex determination using amelogenin proteins in tooth enamel. The top shows X and Y chromosomally encoded protein isoforms (AMELX in blue, AMELY in red) with their amino acid sequences highlighted. The middle section displays amelogenin's structural progression from protein to nanospheres to matrix to enamel rods, alongside images of developing tooth structure with labeled components (ameloblasts, enamel, dentin, odontoblasts, pulp). The bottom shows Raman spectroscopy setup with IR laser and detector analyzing a tooth, demonstrating how incident light produces both Rayleigh scattering and Raman scattering from molecular vibrations, resulting in sex-specific spectra shown in a graph (blue and red lines) with male and female symbols. Biological sex determination is essential for analyzing human skeletal remains in archaeology, anthropology, and forensic science. This study investigates whether Raman spectroscopy of intact human dental enamel can be used as a non-destructive method for sex estimation. Orthogonal partial least squares discriminant analysis (OPLS-DA) and logistic regression identified sex-specific spectral characteristics in 88 human teeth from 47 modern individuals (26 females, 21 males). The OPLS-DA model showed excellent performance, with R2Y(cum) = 0.943 and Q2Y(cum) = 0.895. Raman shift wavenumbers at 373, 1182, and 1600 cm−1 were identified as the most reliable discriminators and included in a final logistic regression model. This model achieved an area under the receiver operating characteristic curve (ROC-AUC) of 0.98, a sensitivity of 0.87, and a specificity of 0.94. Our results indicate that Raman spectroscopy can effectively differentiate male and female human dental enamel based on subtle differences in molecular composition—possibly linked to residual differences between AMELX and AMELY-derived proteins.
🧵 Thread: 1️⃣ Fascinating paper by Stewart et al. shows robust method for sex determination using peptides in tooth enamel.
Great potential for #archaeology with fragmentary remains where DNA is degraded. #palaeoproteomics #ZooMS #teammasspec
figshare.com/s/a861c0d74d...
Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases
Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected
Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...
El modelo tridimensional escalable 'intestino en un chip' permite la visualización en tiempo real de interacciones de microbios intestinales y el intestino humano, lo que es de gran interés para la atención médica preventiva y la industria farmacéutica
SY-Stem 2025 Symposium: Registration deadline on February 15th!
SY-Stem - a symposium focusing on the next generation of stem cell researchers - is organized by IMBA and @impvienna.bsky.social.
Register online: bit.ly/4jekaDg
Check out the program: bit.ly/4jDioM6
ADOA Awareness Day Poster 23 November 2023 Blue graphics with the following stats: 1 out of 30.000 people are affected by ADOA Up to 45% of patients are considered legally blind Progressive vision loss: symptoms include blurry vision, reduced contrast, color blindness and central vision loss No cure: research into a cure is challenging due to the complexity of the condition, but is ongoing.
Today is the first ever ADOA Awareness Day
Autosomal Dominant Optic Atrophy is a rare condition that causes progressive vision loss.
One of my very best friends in the world has this condition, and she is now registered blind.
There is currently no cure - research is ongoing.
