Yisui Xia's Avatar

Yisui Xia

@yyxia.bsky.social

Young PI in Medical School of Shenzhen University on studying DNA replication in metazoa. Postdoc was in Karim Labib Lab.

42 Followers  |  90 Following  |  5 Posts  |  Joined: 26.06.2025  |  1.6106

Latest posts by yyxia.bsky.social on Bluesky


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Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

19.12.2025 18:10 — 👍 10    🔁 6    💬 0    📌 0
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MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....

28.11.2025 11:42 — 👍 6    🔁 4    💬 0    📌 0
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Lots of fun for Masto's visiting😁😁😁

22.11.2025 14:40 — 👍 0    🔁 0    💬 0    📌 0
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Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

12.11.2025 21:26 — 👍 163    🔁 67    💬 5    📌 4

congratulations Hana!

29.10.2025 01:12 — 👍 1    🔁 0    💬 1    📌 0
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Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing

Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...

#LMBResearch

22.10.2025 16:41 — 👍 61    🔁 30    💬 0    📌 2

Great work! Superb!

23.09.2025 03:43 — 👍 1    🔁 0    💬 1    📌 0

Now we are looking for in vitro evidence on MCM UFMylation💪

19.09.2025 02:05 — 👍 2    🔁 0    💬 0    📌 0
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In @jcb.org, the @hanasedlackova.bsky.social lab presents a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

16.07.2025 16:15 — 👍 3    🔁 2    💬 0    📌 0
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Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

16.07.2025 16:15 — 👍 18    🔁 11    💬 1    📌 0
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Last day in Dundee. Sweet 9 years.
Moving on, a step forward from postdoc to young PI.

13.07.2025 09:57 — 👍 7    🔁 0    💬 0    📌 0
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CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

10.07.2025 14:55 — 👍 36    🔁 13    💬 1    📌 1

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