Stephanie Orchanian

Toxoplasma gondii parasites induce a localized myeloid cell immune response surrounding parasites in the brain during acute infection | mBio Toxoplasma gondii is a brain-infecting parasite, and the mobilization of peripheral immune cells to the brain is critical for controlling T. gondii infection. However, the initial events driving these...

Excited to share our recent publication in this month's issue of mBio, based on my PhD research. We show that replication of 𝘛. 𝘨𝘰𝘯𝘥𝘪𝘪 is required to trigger a localized immune response in the brain! 🧠 bit.ly/3TA9ALj

An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice Yu and Chandra et al. engineered a commensal gut microbe, Bacteroides thetaiotaomicron, to detoxify methylmercury (MeHg). The engineered bacterium reduces MeHg in the intestinal lumen, limits its accu...

Thrilled to share this collaborative work by Kristie Yu, Francis Chandra, Amina Schartup and teams @Scripps_Ocean and @UCLA showing that an engineered gut bacterium can be used to reduce the neurotoxic effects of dietary methylmercury www.cell.com/cell-host-mi...

Maternal microbiome is a cornerstone of maternal and fetal health. https://buff.ly/431YoNu

@stephorch.bsky.social‬ & @pipethero.bsky.social highlight gut microbiome x environmental interactions at the maternal-fetal interface that influence the brains of pregnant people and developing offspring.

Curious about how the gut microbiome modulates the neurological health of pregnant women and their offspring? Check out my recent review with @pipethero.bsky.social out now @jclinical-invest.bsky.social! 🦠🤰👶🧠

www.jci.org/articles/vie...