Upbeat Former Prof

i always wish the main sites for neddylation involved the sequence FLANDERS

Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling https://www.biorxiv.org/content/10.64898/2025.12.06.692499v1

Steve Leininger holding up phone booted into LDOS

Steve Leininger, the father of the TRS-80, running TRS-80 software on his phone.

malicious compliance: kids edition

some people have a real problem with the concept that not everything is made for them, and instead assess that participation in such efforts reflects skill issues, moral defects, or similar.

an old copy of the memoir "All Creatures Great and Small," by James Herriott

my thought on one of tonight's Bluesky topics.

Just been reminded of another of my all-time favourites, Ian Curtis rides a rollercoaster...

i hate this, thank you for the recommendation that's going to give me nightmares

their first scene together after switching faces, so awesome. basically Heat's diner scene, John Woo style

"no more drugs for that man" was in no way a friend's favorite saying during college

i mean, cmon, Margaret Cho kicks the crap out of one of the bad guys

there's more movie in the first ten minutes than in the entirety of most Marvel movies

this movie is the peak of Hollywood John Woo and also Nic Cage and also John Travolta.

awesome. Face/Off is back on Netflix.

(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)

Onion headline: Frank Gehry No Longer Allowed To Make Sandwiches for Grandkids, with a picture of a “sandwich” that looks like a Frank Gehry building

RIP Frank Gehry

from yolk to yoke

for my money

theonion.com/shaq-misses-...

man, Alien Covenant is... not good.

i have never felt more like the product

Kohler can make the funniest captcha of all time

It's important to have a job that makes a difference, boys. That's why I manually masturbate caged animals for artificial insemination.

ughh I'm really, really sorry

YouTube video by Musicians Hall of Fame & Museum Steve Cropper - The AMAZING Story Behind "Green Onions"

rest in peace.

youtu.be/o1emR12qb_Y

Steve Cropper, Legendary Guitarist for Booker T. & the MG’s, Otis Redding and the Blues Brothers, Dies at 84 Steve Cropper, guitarist for Booker T. & the MG's, Otis Redding, the Blues Brothers and many more, has died. He was 84.

One of the all-time greats - guitarist, songwriter, producer, icon. Rest easy, Steve. variety.com/2025/music/n...

this is the worst book I've ever downloaded. my storage is embarrassed for me

Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!

this was a surprisingly long journey!

time for a second edition?? 🤞😀

Hi #bioinformatics folk, I want to quickly extract metagenome reads that map to medium-sized piles of reference genomes (100s-1000s, but not 10_000s). I don't _necessarily_ care about the exact position. I'm using minimap2 right now but it's kinda choking on 1000 microbial genomes at once. Thoughts?