Nicole Campbell

🚨 Preprint Alert 🚨

We discovered a new regulator of RIG-I-like receptors #MDA5 #RIG-I, which are critical innate immune sensors of #RNA that detect #viral infection.

Check out our #biorxiv #preprint: www.biorxiv.org/content/10.1...

tl;dr 🙃 thread below

My department is now on Bluesky! A must follow if you want to keep up with some of the best scientists in innate immunity 👩🏼‍🔬👨🏽‍🔬 #immunosky @hudsonresearch.bsky.social

Q for my fellow scientists: you reviewed or authored a paper & when you see all of the reviewers’ comments, it is obvious one reviewer’s was written by ChatGPT, which all relate to the paper’s writing style rather than the actual science presented. Do you contact the handling editor? #sciencesky #AI

Done, welcome to you both! ☺️

Done!

I've been on a bsky hiatus but I'm back to tell you to read this very cool paper if you're interested in IFNs & host-pathogen interactions! Our fav constitutively-expressed IFN, IFN-epsilon, facilitates immune evasion by Neisseria gonorrhoeae via modulation of sialic acid metabolism #immunosky

I’m also grateful to the Mother’s Day Classic Foundation for their support of @ocrfaustralia.bsky.social – funds raised by the MDC will directly support my research to develop a new immunotherapy for ovarian cancer 🙏 @hudsonresearch.bsky.social

I am incredibly honoured to be selected as an OCRF grant awardee in 2025 – every $ awarded by @ocrfaustralia.bsky.social was raised by supporters determined to improve outcomes for patients with ovarian cancer 🩵

Super cool new ovarian cancer research from the Bilandzic group at @hudsonresearch.bsky.social ! #ovariancancer #metastasis #immunosuppression

NHMRC Investigator grant success 2025 Research into autoinflammatory diseases, hypertension, cancer and perinatal brain injury has been funded by NHMRC Investigator grants.

I am incredibly fortunate and delighted to have been awarded a NHMRC Emerging Leadership Level 1 Investigator Grant this year! 🥳 This funding will provide crucial support for my research on interferon epsilon in cancer over the next 5 years. @hudsonresearch.bsky.social #nhmrc #investigatorgrant

Loved this talk from Prof Bowen, great example of how to engage with Aboriginal communities to improve health outcomes both respectfully and effectively 🖤💛❤️@theviin.bsky.social #lorneiandi

We've created a starter pack for everyone attending & supporting this year's Lorne Infection and Immunity Conference! 🔬🧪🦠🏖️

Let us know if you're attending #lorneiandi and would like to be added!

Check out the starter pack here: go.bsky.app/G6cE3nw

Also I was excited to see they used one of my new favourite technologies, proximity labelling, to make this discovery! @theviin.bsky.social

What a great pick for this year’s #lorneiandi Hertzog oration, David Underhill @cedarssinai.bsky.social presenting exciting research (recently published @nature.com !) identifying a role for PDL1 in binding fungi during phagocytosis. Shame @paulh1pjh.bsky.social couldn’t make it this year!

It’s good to be back at #lorneiandi! What a great talk to kick off proceedings by Anca Dorhoi @unigreifswald.bsky.social on hypoxic macrophages in TB infection @theviin.bsky.social

Do you work on #interferons, come join the family!
go.bsky.app/71vKZJA

Done! 😊

Please add me 🙋‍♀️

Also any immunologists who want to be added to the Interferons starter pack, send me a message! go.bsky.app/71vKZJA

The Perfect Cacio e Pepe Recipe, According to Science Italian scientists have drawn from thermodynamic principles to prevent a famous pasta from turning into a gooey mess.

Now this is important research I think we can all get behind!

www.nytimes.com/2025/01/24/s...

“It is a great shame that Ireland is a special case, but the shame is not Ireland’s.”
~Mark O’Connell

The Irish Times

☕️🥐

Thanks Paul! 🥰

Heading to @3rrrfm.bsky.social radio to discuss some of our science on #innateimmunity #inflammation #RNA sensing and what this could mean for new #mRNA therapies. If you’re in Australia, tune into Einstein-A-GoGo this morning at 11 am. Podcast link to follow! @hudsonresearch.bsky.social #immunosky

Thanks! Missed you yesterday!

Another year, another science-themed cake for the @hudsonresearch.bsky.social CiiiD EOY party! This edible board game is made from gingerbread & royal icing, with a hidden medovik (honey cake) inside! It was a labour of love but lots of fun to make! #sciencesky #immunosky #bakingsky #sciencebakes

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.

If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X

www.science.org/doi/10.1126/...

#RNASky #ImmunoSky

Done! 🙂

This new research challenges these previous assumptions by defining a protective role for constitutively-expressed IFNe in the testis. It is hoped that future research aimed at understanding the regulation & activity of IFNe in the testis will lead to new treatments for Zika & male infertility! 3/3

IFNe expression in the female reproductive tract has already been well characterised by our group & others (see Fung et al 2013). However, the testis has long been believed to be an 'immune privileged' site deficient in antiviral defences, allowing it to act as a reservoir for viruses. 2/3

Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage Author summary Many clinically significant viruses can infect the testis, affecting male fertility, and the health of the partners and children of infected men. Crucially, many viruses are transmitted...

🚨IFN fans!🚨New research on IFN-epsilon just dropped: IFNe is constitutively expressed in the testis & protects the male reproductive tract from Zika virus infection! This work was led by the wonderful @drruki1.bsky.social @hudsonresearch.bsky.social #immunosky 1/3

journals.plos.org/plospathogen...

I also saw this talk at ECI! So good 🤩