Jake Stevens

I'm so excited to see the future of this work and the studies that will hopefully pave the way for a therapeutic use!

Couldn't thank Hitesh Deshmukh, Erica Culberson, co-first author, and the rest of the lab and our collaborators enough for such a dream PhD story.

09.06.2025 19:13 — 👍 0    🔁 0    💬 0    📌 0

When this axis is disrupted by exposure to antibiotics, newborns have immediate, and long-lasting, consequences for their adaptive pulmonary immune responses. The fact that we can also restore these responses and protection for newborns with exogenous supplementation of inosine is so exciting too.

09.06.2025 19:13 — 👍 0    🔁 0    💬 1    📌 0

Important members of the microbiota, particularly Bifidobacterium, produce inosine, which is essential for NFIL3-dependent instruction of proper CD8+ T cell responses against influenza early in life.

09.06.2025 19:12 — 👍 0    🔁 0    💬 1    📌 0

Really couldn't be more proud to have the last chapter of my PhD finally out in publication at @cellpress.bsky.social.

We looked at the mechanisms behind how the developing gut microbiota in newborns plays a role in education of the pulmonary immune response against respiratory viruses.

09.06.2025 19:10 — 👍 3    🔁 1    💬 2    📌 0

That's all the new stuff for now! Excited to see how this platform works for scientific communication and continue updating as I finish up my MD/PhD and look forward to residency and beyond.

16.12.2024 00:24 — 👍 0    🔁 0    💬 0    📌 0

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns The immunological defects causing susceptibility to severe viral respiratory infections due to early-life dysbiosis remain ill-defined. Here, we show that influenza virus susceptibility in dysbiotic i...

And this is the second paper from my PhD, still in preprint, but hopefully out soon! We found a novel mechanism for T cell programming by the gut microbiota early in life important for protection against influenza. Some really cool mechanistic immunology and use of human data sets.

16.12.2024 00:23 — 👍 3    🔁 0    💬 0    📌 0

The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota Gut microbiota promote recovery from pneumonia by reinforcing the balance between homeostasis and inflammation in neonatal lungs.

This was the first paper from my PhD, where we found that the gut microbiota programs pulmonary innate immune responses to bacterial pneumonia in non-human primates. It was a great look at unique neutrophil populations in the lungs important in early-life host defense!

16.12.2024 00:19 — 👍 2    🔁 0    💬 0    📌 0

Here's a recap from finishing the PhD part of my MD/PhD! It was a great time in the Deshmukh Lab, learning about newborn pulmonary immune development.

Now over halfway through the 3rd year of medical school, it's been awesome seeing how scientific advances fit into clinical care.

16.12.2024 00:15 — 👍 0    🔁 0    💬 0    📌 0

It won't really work well to transfer over everything from X, so I'll take this chance to start new!

16.12.2024 00:13 — 👍 0    🔁 0    💬 0    📌 0

Intro:

Hi everyone! My name is Jake- MD/PhD student at UCCOM and Cincy Children's. PhD on how antibiotics affect newborn immune responses to pneumonia. Interested in peds-critical care. I love running and cycling- an attempt to outpace the many ups and downs of med/grad school. Moving over from X!

16.12.2024 00:08 — 👍 2    🔁 0    💬 0    📌 0