Dr Kevin Lee

Mark is beloved by millions of kids, which makes it particularly great that he’s teaching them how to inform their parents that Tesla is a danger to children. This is another one of those “we don’t need a ‘Rogan of the left’, we need normal men” examples.

Mundus sine Caesaribus

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE) Background and Objectives: The socioeconomic working group of the European myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Research Network (EUROMENE) has conducted a review of the literat...

Research on GP knowledge of #MECFS - based on pre-COVID data: “a third to a half of all GPs did not accept ME/CFS as a genuine clinical entity and, even when they did, they lacked confidence in diagnosing or managing it.” Though acknowledging mostly UK data
www.mdpi.com/1648-9144/57...

Abstract Myalgic encephalomyelitis (ME/CFS) a chronic, disabling illness with no established etiopathology. It has been indicated in some population-based studies that Black and ethnic minority populations are underdiagnosed with ME/CFS. The aims of the present study were to (1) identify the agreement between receiving an ME/CFS diagnosis and meeting diagnostic criteria, (2) identify the demographic characteristics associated with receiving a diagnosis, and (3) explore patient satisfaction with healthcare. Self-reported medical history and symptoms were collected via online survey from respondents with and without fatigue. The agreement between self-reporting an ME/CFS diagnosis and meeting the Center for Disease Control’s (CDC) ME/CFS criteria or Institute of Medicine (IOM) criteria was assessed with Cohen’s kappa. Patient characteristics predicting a physician diagnosis were analyzed with logistic regression. Associations between diagnosis, demographics, and healthcare satisfaction were assessed with chi-square tests of independence. There were 1110 responses. The agreement between meeting ME/CFS criteria and reporting an ME/CFS diagnosis was fair (CDC: κ = 0.29; SE = 0.02; IOM: κ = 0.28, SE = 0.03). White respondents had 2.94 greater odds of being diagnosed with ME/CFS than non-White respondents. Having an ME/CFS diagnosis was associated with dissatisfaction with healthcare (χ2 (3, N = 1063) = 14.17, p = 0.003). The findings suggest racial disparities in the diagnostic processes for ME/CFS. Keywords: bias; social determinants of health; minority; long COVID; inequality

Possible Racial Disparities in the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

www.mdpi.com/1660-4601/22...

"White respondents had 2.94 greater odds of being diagnosed with ME/CFS than non-White respondents"

#MEcfs #CFS

Area chart showing ME funding (£6m) vs. MS, IBD and Parkinson's by the UK Government, 2015-20

A comparison of UK Government research funding for ME/CFS compared to other diseases like MS, IBD and Parkinson's 🧐

@nihr.bsky.social and @ukri.org we need ring-fenced funding for ME as part of the Delivery Plan

Thank you to @mediumwhite.bsky.social & co. for analysis

#MECFS #NHS

ifnmujournal.com/gmj/article/... adolescent #t1dm clinic study - 25/70 pts (36%) positive bedside test for #POTS- HbA1c in that group high- 10.4%

This is a good and bad paper at the same time - if you compare #MECFS to #LongCovid in any scientific context, you must compare LC+PEM (i.e., ME from Covid) to #MECFS. Otherwise, you get the average of symptoms from any post-Covid condition.

With so much attention on NIH lately, can’t help but bring up lack of research focus of #myalgicencephalomyelitis #MECFS by NIH over the years. It’s so low make you wonder if intentional content.iospress.com/articles/wor...

I think it’s quite clear to outsiders- 🇺🇸 land of the bigsoda, bigsugar, bigfastfood, also the land of the biotech, pharma. Can’t make 🇺🇸 healthy without addressing the former

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep - PubMed As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic removal of waste products, are activated. Yet, it is n...

Long COVID further disrupts sleep, and poor sleep causes even more damage. Ensuring better sleep for patients should be a priority. 3/3
pubmed.ncbi.nlm.nih.gov/39788123/

COVID-related conditions should be integrated into medical education rather than being left to so-called ‘Long COVID clinics.’ When those in charge lack a real understanding of the condition, these clinics end up becoming gaslighting centers. Physician education must come first.

Figure 3. Quercetin’s Enhancement of Macroautophagy for Cellular Regulation. The quercetin’s dynamic role in bolstering macroautophagy is a critical cellular process for maintaining homeostasis through the degradation and recycling of proteins and organelles. Quercetin modulates the mechanistic target of rapamycin (mTOR) pathway and activates AMP-activated protein kinase (AMPK), leading to decreased mTOR activity and the initiation of autophagy.

www.frontiersin.org/journals/pha... #Quercetin Enhancement of Macroautophagy for Cellular Regulation. Its dynamic role in bolstering macroautophagy is a critical cellular process for maintaining homeostasis

Just reflecting on the realisation that my medical education taught me much more about Munchausen’s, which I have rarely if ever seen, than ME/CFS, which I now see near daily.

It’s 2025, there really is no excuse to get blank looks from HCPs in Australia when #MyalgicEncephalomyelitis #MECFS is mentioned, policy makers should do more to ensure such given the health equity and access that pwME pwLC deserve

A small study but #mecfs pts with or without “psychogenic pseudosyncope “ diagnosis, greater orthostatic 🧠 blood flow drop pmc.ncbi.nlm.nih.gov/articles/PMC...

Logos for the British Psychological Society, Action for ME & ME Association Good Practice Guidelines for Psychologists Working with People with ME/CFS November 2024 Update Screenshot of 1st 2 paragraphs

🧵
Good Practice Guidelines for Psychologists Working with People with ME/CFS November 2024 Update

meassociation.org.uk/wp-content/u...

Although this isn't brand new, I found it interesting so I'm going to post some extracts to this thread.

#MEcfs #CFS #PwME

1/

Humankind prior to 8 ka consisted of fewer than 50 million people, many of whom were migratory. Modern
human civilization in the 21st century is projected to near 10 billion people, hundreds of millions of whom live in permanent coastal communities that cannot be relocated inland.

Serum Spike Protein Persistence Post COVID Is Not Associated with ME/CFS Background/Objectives: According to the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), an estimated 3–6% of people suffer from post-COVID condition or syndrome (...

MDPI: “Serum Spike Protein Persistence Post COVID Is Not Associated with ME/CFS”

“this study provides further evidence for serum spike persistence in a subset of individuals after SARS-CoV-2 but found no association with ME/CFS or symptom severity”

www.mdpi.com/2077-0383/14...

Medical School Engagement Program Opens Pathways to Endocrinology Sacha Uelmen, Director, Professional & Clinical Affairs: "There is an alarming shortage of U.S. medical students choosing to enter the field of endocrinology, a situation exacerbated by the declining ...

American endocrinologist shortages , one issue : “increase in referrals for diagnoses typically managed by primary care is further exacerbating access issues for patients with more complex cases when an endocrinology consult is critical and necessary” www.endocrine.org/news-and-adv...

GP Educational Webinar on PVFS and ME/CFS Dr Ros Vallings, a New Zealand GP who is an expert on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), will present a free talk entitled 'Key Messages for Primary Care on the Diagnosis and Management of Post Viral Fatigue Syndrome and ME/Chronic Fatigue Syndrome', followed by a Q&A session on Tuesday, April 8 at 7:30pm. Accreditation applied for from the Irish College of GPs For more information, contact CPD@irishmecfs.org 38 FORUM January/February 2025

An ad we & the Irish ME Trust are running in this month's Forum magazine for Irish GPs in advance of our free webinar in April

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome

Hypoglycemia Associated With Hypermobile Ehlers-Danlos Syndrome Hypoglycemia in the absence of diabetes is often multifactorial and challenging to diagnose definitively. We present a case report and an expanded series of adult females with reactive hypoglycemia wh...

Glad to see other groups seeing the same thing, as it’s been puzzling that it’s common enough but so under appreciated- hypoglycemia in hypermobile Ehlers Danlos pmc.ncbi.nlm.nih.gov/articles/PMC...

Does COVID increase the risk of Alzheimer’s disease? COVID-19, even in mild cases, is linked to changes in Alzheimer’s disease-related brain biomarkers comparable to four years of aging. This study raises concerns about long-term neurological risks and ...

“Overall, the study provided new evidence that COVID-19 may accelerate Alzheimer’s disease-related brain changes, even in individuals with mild infections. The observed alterations in plasma biomarkers suggested a potential long-term impact on brain health.”

www.news-medical.net/news/2025020...

BPS Publications Aims To investigate the statistical association between hypoglycaemia and β-blocker use and to define what patient and drug characteristics could potentially increase the risk for its occurrence. ...

Beta‐blocker‐associated hypoglycaemia bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

1 in 22 COVID survivors develop debilitating chronic syndrome A study suggests that catching COVID-19 significantly raises the risk of developing ME/CFS (formerly called "chronic fatigue syndrome"), a typically lifelong condition that can be debilitating.

When I trained in medicine I was told that Chronic Fatigue Syndrome (CFS/ME) was rare. I expected to see a handful of cases in my whole career.

Now I have Long Covid related CFS myself, I know of many affected colleagues, & saddest of all, 3 of my kids’ friends.

www.livescience.com/health/coron...

Important work from Australian group. It’s interesting that rather than novel, probably just forgotten by clinicians. Brain perfusion SPECT been used in #MECFS for years, it’s part of the diagnostic primer for medical practitioners from 2012 www.investinme.org/Documents/Gu...

Cochrane Review is...

Quercetin Protects Human Thyroid Cells against Cadmium Toxicity Various natural compounds have been successfully tested for preventing or counteracting the toxic effects of exposure to heavy metals. In this study, we analyzed the effects of cadmium chloride (CdCl2...

Another study on beneficial effects of #quercetin in thyroid dz= this one on benefits against cadmium induced thyrotoxicity pmc.ncbi.nlm.nih.gov/articles/PMC...

Schematic representation of different signaling pathways and targets by quercetin as a potential therapeutic strategy in autoimmune diseases.

MMI vs autoimmune induced hypothyroidism, then potentially even more compelling mechanisms of quercetin - pmc.ncbi.nlm.nih.gov/articles/PMC...
Any human study on significant impact on thyroid function? Papers on in vitro studies, or in vivo rodent studies, tend to be quite speculative

To Explore the Inhibitory Mechanism of Quercetin in Thyroid Papillary Carcinoma through Network Pharmacology and Experiments Quercetin, a flavonoid with anti-inflammatory and anticancer properties, is expected to be an innovative anticancer therapeutic agent for papillary thyroid carcinoma (PTC). However, the downstream si...

The anti thyroid cancer effect of #quercetin have been explored also onlinelibrary.wiley.com/doi/10.1155/...

Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L-thyroxin (LT4)-induced hyperthyroidism rat...

#quercetin alleviates hyperthyroidism induced liver damage iubmb.onlinelibrary.wiley.com/doi/abs/10.1...