Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity - Scientific Reports Scientific Reports - Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity

5-HT-mediated depolarization of OFC PV neurons occurs via activation of 2A, not 2C, receptors. And 2A antagonism works similarly in males and females www.nature.com/articles/s41...

Sex‐Specific Adaptations to VTA Circuits Following Subchronic Stress Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...

New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

www.nature.com/articles/s41...

Dev bio is amazing !!

Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations - Nature Communications Functional roles of natural acetylcholine (ACh) dynamics are not fully understood. This study reveals dynamic changes in ACh release across the mouse striatum during learning and extinction, identifyi...

Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
www.nature.com/articles/s41...

Local inhibitory circuits mediate cortical reactivations and memory consolidation Reducing inhibitory activity after training prevents cortical reactivations and memory consolidation.

New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...

🧠 🍄 ⚡️🐭

Now published in @natneuro.nature.com

Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility

nature.com/articles/s4159…

Our latest work extends ketamine’s antidepressant action and highlights the importance of a specific form of synaptic plasticity in the effects

www.science.org/doi/10.1126/...

Brainstem sensing of multiple body signals during food consumption Studies of body-to-brain communication often examine one stimulus or organ at a time, yet the brain must integrate many body signals during behavior. For example, food consumption generates diverse or...

I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. www.biorxiv.org/content/10.1...

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Our new paper is out in Science.

What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.

Congrats Jake!

www.science.org/doi/10.1126/...

different coloured mice on a white background

Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx

Thrilled to share our lab's first preprint on the neural mechanisms underlying helping behavior in mice! 🧠🐭 We show that dorsal hippocampal networks play a key role in rescuing a distressed peer: www.biorxiv.org/content/10.1...

Circuit organization of the rodent medial prefrontal cortex The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons a...

This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨

Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.

More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...

🧠📈

Dual neuromodulatory dynamics underlie birdsong learning - Nature Dopamine release in the basal ganglia of the zebra finch is driven by neurons associated with reinforcement learning and by cholinergic signalling, and tracks performance quality during long-term lear...

Proud to have contributed to @jiaxuanqi.bsky.social's masterpiece out @nature.com! She shows that dopamine transients track the learned quality of song during juvenile learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! (1/x)

Thalamic opioids from POMC satiety neurons switch on sugar appetite High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

🧠🍽️ Satiety neurons that make you crave sugar? 🍬 New research shows that POMC neurons, typically linked to appetite suppression, release opioids in the thalamus, flipping the switch to increase sugar intake.

#neuroskyence 🧪 #appetite

Overwriting an instinct: Visual cortex instructs learning to suppress fear responses Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals can adapt their behavior and suppress instinctive reactions, but the neural pathways...

Overwriting an instinct: Visual cortex instructs learning to suppress fear responses | Science www.science.org/doi/10.1126/...
#neuroskyence

Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior - Nature Neuroscience Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective manipulation of tagged astrocyte...

An #astrocytic ensemble that emerges in the nucleus accumbens upon activity during cue-motivated behaviors and is essential for modulating cue-reward associations 🧪🧪

www.nature.com/articles/s41...

Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.

The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/basal-gangli...

Sexually dimorphic dopaminergic circuits determine sex preference Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...

Womp-womp:😂😂😂

Sexually dimorphic dopaminergic circuits determine sex preference

www.science.org/doi/10.1126/...

#Neuroscience #Sex

How dopamine enables learning from aversion Dopamine is heavily studied for its role in reward learning, but it is becoming increasingly appreciated that dopamine can also enable learning from a…

As I board my flight home for the holidays, I wanted to share that a review I wrote with @talialerner.bsky.social just came out! It’s titled “How dopamine enables learning from aversion.” Super grateful for the opportunity - hope you can check it out! 😊😊🎄🎄
www.sciencedirect.com/science/arti...

🚨 New preprint from the Lerner Lab 🚨

Gaby Lopez et al looked at how "rewarding" and "aversive" dopamine signals in the NAc evolve during negative reinforcement learning, with some fascinating results!

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors - Nature Neuroscience Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.

www.nature.com/articles/s41...

Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.

no there isnt
bsky.app/profile/mjpa...

Understanding the molecular diversity of synapses - Nature Reviews Neuroscience The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...

Such a nice, comprehensive review by @marcvoo.bsky.social and @erin-schuman.bsky.social on the molecular diversity of synapses (h/t @djabaudon.bsky.social):
www.nature.com/articles/s41...

Myelin plasticity in the ventral tegmental area is required for opioid reward - Nature Oligodendrogenesis is shown to be involved in reward learning, with dopaminergic neuronal activity-regulated myelin plasticity being an important reward circuit modification.

Awesome beautiful talk by Michelle Monje at the #ACNP2024 President's Plenary - especially the part highlighting changes in dopamine axon myelination with drugs of abuse! 🤩
Work led by Belgin Yalcin
www.nature.com/articles/s41...

to each their own I guess. If youre going to these people looking for answers to spiritual questions in life, thats great. But if youre looking for answers to questions about natural phenomena, I warn you that you will be misled and disappointed

in my experience these institutions are at the absolute fringes of neuroscience as their research is flawed and largely unconvincing. In fact, I wouldn't even consider their work neuroscience in any serious sense: its mostly philosophical work

In our paper @currentbiology.bsky.social we uncover the tactile & afferent mechanisms of the rat pup transport response.

Teamwork ✋ Zheyi, Connor, Arturo, Marta, Yu, Michael @sidb-edinburgh.bsky.social @edinunineuro.bsky.social @mblscience.bsky.social

Read the dispatch too!

tinyurl.com/4ez3k9uw

Understanding the neural code of stress to control anhedonia - Nature Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...

I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...

As someone in the neuroscience space, I have never heard of this subculture. could you elaborate?